Title: Effingham, SC Car Rental - Free Cancellation Options - Expedia.com [Effingham Travel Guide](https://expedia.com/Effingham.dx553248635975849973)[Hotels in Effingham](https://expedia.com/Effingham-Hotels.d553248635975849973.Travel-Guide-Hotels)[Flights to Effingham](https://expedia.com/Cheap-Flights-To-Effingham.d553248635975849973.Travel-Guide-Flights)[Effingham Vacation Packages](https://expedia.com/Effingham.d553248635975849973.Destination-Travel-Guides) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # $99 Car Rental Effingham, SC ## Search and Compare from Car Companies in Effingham ## Featured car rental suppliers Compare from agencies ![car suppliers logo](https://forever.travel-assets.com/flex/flexmanager/images/2022/02/16/car-suppliers-logo-desktop.jpg) ## Top Car Deals in Effingham \* Price found within the past 6 days. Click for updated prices. Wed, Feb 18 - Thu, Feb 19 ### Standard SportsCar Dodge Challenger or similar - 4 people - Unlimited mileage ![Enterprise](//mediaim.expedia.com/cars/logos/ET.png) Florence, South Carolina, USA ![Dodge Challenger](//mediaim.expedia.com/cars/15/e618b412-ec29-43ca-acd5-6bcec45ab089.jpg) #### $99 includes taxes & fees $75 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193523&olon=-79.728341&date1=2/18/2026&date2=2/19/2026&pprfrr=75.0&tprfrr=98.51&cvrfrr=ET&ctrfrr=SS&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22sportscar%22]) Wed, Feb 18 - Thu, Feb 19 ### Economy Mitsubishi Mirage or similar - 4 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Mitsubishi Mirage](//mediaim.expedia.com/cars/6/46ee7f31-3f7e-470b-ac4e-11870a3545b5.jpg) #### $99 includes taxes & fees $76 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=75.73&tprfrr=99.38&cvrfrr=AL&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Wed, Feb 18 - Thu, Feb 19 ### Compact Nissan Versa or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Nissan Versa](//mediaim.expedia.com/cars/6/43471784-4195-4485-b8fc-e46acb4ea853.jpg) #### $101 includes taxes & fees $77 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=76.69&tprfrr=100.54&cvrfrr=AL&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Wed, Feb 18 - Thu, Feb 19 ### Midsize Toyota Corolla or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Toyota Corolla](//mediaim.expedia.com/cars/6/71d0b52d-3e7c-464d-a7c8-e0168d620b86.jpg) #### $102 includes taxes & fees $78 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=77.64&tprfrr=101.68&cvrfrr=AL&ctrfrr=IC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22midsize%22]) Wed, Feb 18 - Thu, Feb 19 ### Fullsize Chevrolet Malibu or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Chevrolet Malibu](//mediaim.expedia.com/cars/6/ddd8338b-26b6-4e7a-b523-60afec3bfa36.jpg) #### $103 includes taxes & fees $79 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=78.59&tprfrr=102.82&cvrfrr=AL&ctrfrr=FC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Wed, Feb 18 - Thu, Feb 19 ### Special Mystery Car May Be Gas Hybrid or EV or similar - 3 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) Florence, South Carolina, USA ![Mystery Car May Be Gas Hybrid or EV](//mediaim.expedia.com/cars/41/6adf30b0-3543-4560-b760-d0c7751bb2a0.jpg) #### $107 includes taxes & fees $85 per day found 12 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.183330&olon=-79.716660&date1=2/18/2026&date2=2/19/2026&pprfrr=84.99&tprfrr=106.88&cvrfrr=ZI&ctrfrr=XX&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22other%22]) Wed, Feb 18 - Thu, Feb 19 ### Premium Pickup Regular Cab Ford F150 or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Ford F150](//mediaim.expedia.com/cars/6/540fb0f7-9b8f-4fbc-93be-7057b591d5a3.jpg) #### $112 includes taxes & fees $86 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=86.1&tprfrr=111.83&cvrfrr=AL&ctrfrr=PP&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22pickup%22]) Wed, Feb 18 - Thu, Feb 19 ### Standard Elite Special Ford Mustang Mach-E or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Florence, South Carolina, USA ![Ford Mustang Mach-E](//mediaim.expedia.com/cars/39/9eb70d2f-e3e7-4e36-9e24-1505e077c35a.jpg) #### $119 includes taxes & fees $95 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193626&olon=-79.728890&date1=2/18/2026&date2=2/19/2026&pprfrr=94.99&tprfrr=118.88&cvrfrr=ZD&ctrfrr=RX&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22standard%22]) Wed, Feb 18 - Thu, Feb 19 ### Mini Van Chrysler Pacifica or similar - 7 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Chrysler Pacifica](//mediaim.expedia.com/cars/6/f9590605-5c45-4085-bc98-610d18971c37.jpg) #### $122 includes taxes & fees $95 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=94.75&tprfrr=122.21&cvrfrr=AL&ctrfrr=MV&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22minivan%22]) Wed, Feb 18 - Thu, Feb 19 ### Luxury Audi A4 or BMW 3 Series or similar - 5 people - Unlimited mileage ![Alamo](//mediaim.expedia.com/cars/logos/AL.png) Florence, South Carolina, USA ![Audi A4 or BMW 3 Series](//mediaim.expedia.com/cars/6/f84d223e-53e9-443e-bfd1-5b43e349e9be.jpg) #### $123 includes taxes & fees $95 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193460&olon=-79.728970&date1=2/18/2026&date2=2/19/2026&pprfrr=95.26&tprfrr=122.82&cvrfrr=AL&ctrfrr=LC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22luxury%22]) Wed, Feb 18 - Thu, Feb 19 ### Midsize Elite Tesla Short Range Model 3 or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) Florence, South Carolina, USA ![Tesla Short Range Model 3](//mediaim.expedia.com/cars/41/0ac156b6-4dc7-450c-90e2-8f4e9c0dda1d.jpg) #### $121 includes taxes & fees $97 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.183330&olon=-79.716660&date1=2/18/2026&date2=2/19/2026&pprfrr=96.99&tprfrr=121.28&cvrfrr=ZI&ctrfrr=JC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22midsize%22]) Wed, Feb 18 - Thu, Feb 19 ### Premium Elite Crossover Cadillac XT6 or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Florence, South Carolina, USA ![Cadillac XT6](//mediaim.expedia.com/cars/39/9e793c1d-83f5-4a14-b1a8-5152013888dc.jpg) #### $151 includes taxes & fees $122 per day found 9 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193626&olon=-79.728890&date1=2/18/2026&date2=2/19/2026&pprfrr=121.99&tprfrr=151.28&cvrfrr=ZD&ctrfrr=UG&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Wed, Feb 18 - Thu, Feb 19 ### Luxury Elite Genesis G80E or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) Florence, South Carolina, USA ![Genesis G80E](//mediaim.expedia.com/cars/39/8cfce1f9-4e0c-482d-8c45-0b135c4d0b15.jpg) #### $212 includes taxes & fees $173 per day found 10 hours ago [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=34.193626&olon=-79.728890&date1=2/18/2026&date2=2/19/2026&pprfrr=172.99&tprfrr=212.48&cvrfrr=ZD&ctrfrr=WC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22luxury%22]) ### Don't see what you're looking for? See all car rentals in Effingham [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Effingham,%20South%20Carolina,%20United%20States%20of%20America&dpln=553248635975849973&date1=2/23/2026&date2=2/25/2026&crfrr=defaultFlex&SearchType=Place) Lowest prices found within the past 9 hours. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=CTG_SPRING_PROMO_553248635975849973) ## Frequently asked questions ### How much is a rental car per day in Effingham? ### Can I rent a car from Florence Regional Airport (FLO)? ### What happens if I need to cancel my Effingham car reservation? ### Where can I go on a road trip from Effingham? > - Columbia is around 75 miles from Effingham. Well-known tourist spots like South Carolina State House deserve to be high on your must-see list while you're in town. > - Situated 100 miles away, Charlotte is also popular with travelers. Allow time to take in Spectrum Center while you're here. It's one of the reasons people love coming to this colorful city. > - Biltmore Estate is located 190 miles from Effingham and is one of the region's most breathtaking nature spots. Go for a walk around and enjoy the fresh air. ### How do I find the best car rental deals in Effingham with Expedia? ### How old do you have to be to rent a car in Effingham? ### What do you need to rent a car in Effingham? ### What is the cheapest car rental in Effingham? ### Can I rent a car for a month or longer in Effingham? ### Where can I find an Effingham car rental if I am younger than 25? ### What insurance should I choose for my car rental in Effingham? ## Car Rental Information | Popular car types | [SUV](https://www.expedia.com/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.com/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.com/lp/b/car-rental/economy?rfrr=car.table.Economy) | | ------------------------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available | | | Our best deal of the day | $99 | | Our second best deal of the day | $101 | | Our third best deal of the day | $102 | | From the airport to your hotel | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Finding the cheapest car rentals in Effingham ### **Using our Search Wizard** If the deals that are available on our page do not suit your needs, then enter Effingham into the search wizard at the top of the page. We will compare all the best deals available for your car rental in Effingham and provide you with a list of the cheapest options, with no added fees. ### **Renting a car in Effingham** Pay at pickup is available, so you don’t have to worry about spending your money until you arrive at your vehicle in Effingham. We partner with reliable partners that guarantee an enjoyable experience for solo travelers, couples, and families. Package your car with a flight or hotel to unlock even more savings from Expedia. ### **Expected prices in Effingham** Prices are subject to seasonal change depending on when you decide to arrange your car rental but right now you can book from $99. ### **Flexibility & Cancellation** Most car suppliers offer penalty-free cancellations, so you don’t have to worry about losing money if your plans change. To cancel your booking log into your account through the [Trips](https://www.expedia.com/trips) portal. Click manage booking and cancel this car. If you needed to alter your booking, then you can create a new one once you have canceled. ### **We all love being rewarded** [One Key](https://www.expedia.com/welcome-one-key?langid=1033) members save 10% or more on select hotels, cars, activities and vacation rentals. Not only that, earn OneKeyCash for every dollar spent on eligible hotels, vacation rentals, flights, car rentals, and more when you book across our family of brands: Expedia, Hotels.com and VRBO. Learn more and join today. ### **Car classes available from Expedia in 2026** The classes of vehicles available will change depending on your chosen location. - [Compact car rentals](https://www.expedia.com/lp/b/car-rental/compact) - [Convertible car rentals](https://www.expedia.com/lp/b/car-rental/convertible) - [Economy car rentals](https://www.expedia.com/lp/b/car-rental/economy) - [Fullsize car rentals](https://www.expedia.com/lp/b/car-rental/fullsize) - [Luxury car rentals](https://www.expedia.com/lp/b/car-rental/luxury) - [Midsize car rentals](https://www.expedia.com/lp/b/car-rental/midsize) - [Mini car rentals](https://www.expedia.com/lp/b/car-rental/mini) - [Minivan rentals](https://www.expedia.com/lp/b/car-rental/minivan) - [Pickup car rentals](https://www.expedia.com/lp/b/car-rental/pickup) - [Premium car rentals](https://www.expedia.com/lp/b/car-rental/premium) - [Sportscar rentals](https://www.expedia.com/lp/b/car-rental/sportscar) - [Standard car rentals](https://www.expedia.com/lp/b/car-rental/standard) - [SUV rentals](https://www.expedia.com/lp/b/car-rental/suv) - [Van rentals](https://www.expedia.com/lp/b/car-rental/van) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Coward Hotels ](https://www.expedia.com/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Farmstay in Coward ](https://www.expedia.com/Coward-Agritourism.d3000353109-aaAgritourism.Travel-Guide-Accommodation) - [3 Star Hotels in Coward ](https://www.expedia.com/3Star-Coward-Hotels.s30-0-d3000353109.Travel-Guide-Filter-Hotels) - [Florence Hotels ](https://www.expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels) - [Hotels near Florence National Cemetery ](https://www.expedia.com/Florence-National-Cemetery-Hotels.0-l553248621532657341-0.Travel-Guide-Filter-Hotels) - [Hotels near Florence Museum ](https://www.expedia.com/Florence-Museum-Hotels.0-l6162137-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Florence ](https://www.expedia.com/Florence-Hotels-Cheap-Hotels.0-0-d1221-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels near Florence Regional ](https://www.expedia.com/Florence-Regional-Airport-Hotels.0-aFLO-0.Travel-Guide-Filter-Hotels) - [Pet-friendly Hotels in Florence ](https://www.expedia.com/Florence-Hotels-Pet-Friendly-Hotel.0-0-d1221-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Flights to Coward ](https://www.expedia.com/Cheap-Flights-To-Coward.d3000353109.Travel-Guide-Flights) - [Flights from Florence Regional ](https://www.expedia.com/lp/airports/flo/flights-from-florence-regional-airport) - [Flights to Florence ](https://www.expedia.com/Cheap-Flights-To-Florence.d1221.Travel-Guide-Flights) - [Flights from New York (JFK) to Florence (FLO) ](https://www.expedia.com/lp/flights/jfk/flo/new-york-to-florence) - [Flights from Charlotte (CLT) to Florence (FLO) ](https://www.expedia.com/lp/flights/clt/flo/charlotte-to-florence) - [Flights from Boston (BOS) to Florence (FLO) ](https://www.expedia.com/lp/flights/bos/flo/boston-to-florence) - [Flights from Charleston (CHS) to Florence (FLO) ](https://www.expedia.com/lp/flights/chs/flo/charleston-to-florence) - [Flights from St. Louis (STL) to Florence (FLO) ](https://www.expedia.com/lp/flights/stl/flo/st-louis-to-florence) - [Flights from Myrtle Beach (MYR) to Florence (FLO) ](https://www.expedia.com/lp/flights/myr/flo/myrtle-beach-to-florence) - [Flights from Atlanta (ATL) to Florence (FLO) ](https://www.expedia.com/lp/flights/atl/flo/atlanta-to-florence) - [Flights from Nashville (BNA) to Florence (FLO) ](https://www.expedia.com/lp/flights/bna/flo/nashville-to-florence) - [Flights from Las Vegas (LAS) to Florence (FLO) ](https://www.expedia.com/lp/flights/las/flo/las-vegas-to-florence) - [Flights from Washington (DCA) to Florence (FLO) ](https://www.expedia.com/lp/flights/dca/flo/washington-to-florence) - [Flights from Houston (IAH) to Florence (FLO) ](https://www.expedia.com/lp/flights/iah/flo/houston-to-florence) - [Flights from New York (LGA) to Florence (FLO) ](https://www.expedia.com/lp/flights/lga/flo/new-york-to-florence) - [Flights from Columbia (CAE) to Florence (FLO) ](https://www.expedia.com/lp/flights/cae/flo/columbia-to-florence) - [Flights from Jacksonville (JAX) to Florence (FLO) ](https://www.expedia.com/lp/flights/jax/flo/jacksonville-to-florence) - [Flights from Chicago (ORD) to Florence (FLO) ](https://www.expedia.com/lp/flights/ord/flo/chicago-to-florence) - [Flights from Baltimore (BWI) to Florence (FLO) ](https://www.expedia.com/lp/flights/bwi/flo/baltimore-to-florence) - [Flights from Philadelphia (PHL) to Florence (FLO) ](https://www.expedia.com/lp/flights/phl/flo/philadelphia-to-florence) - [Flights from Hartford (BDL) to Florence (FLO) ](https://www.expedia.com/lp/flights/bdl/flo/hartford-to-florence) - [Flights from Tampa (TPA) to Florence (FLO) ](https://www.expedia.com/lp/flights/tpa/flo/tampa-to-florence) - [Flights from Greenville (GSP) to Florence (FLO) ](https://www.expedia.com/lp/flights/gsp/flo/greenville-to-florence) - [Flights from Dallas (DFW) to Florence (FLO) ](https://www.expedia.com/lp/flights/dfw/flo/dallas-to-florence) - [Flights from Rochester (ROC) to Florence (FLO) ](https://www.expedia.com/lp/flights/roc/flo/rochester-to-florence) - [Flights from Orlando (MCO) to Florence (FLO) ](https://www.expedia.com/lp/flights/mco/flo/orlando-to-florence) - [Flights from Oklahoma City (OKC) to Florence (FLO) ](https://www.expedia.com/lp/flights/okc/flo/oklahoma-city-to-florence) - [Flights from Huntsville (HSV) to Florence (FLO) ](https://www.expedia.com/lp/flights/hsv/flo/huntsville-to-florence) - [Flights from Los Angeles (LAX) to Florence (FLO) ](https://www.expedia.com/lp/flights/lax/flo/los-angeles-to-florence) - [Flights from Phoenix (PHX) to Florence (FLO) ](https://www.expedia.com/lp/flights/phx/flo/phoenix-to-florence) - [Flights from Fort Lauderdale (FLL) to Florence (FLO) ](https://www.expedia.com/lp/flights/fll/flo/fort-lauderdale-to-florence) - [Flights from Miami (MIA) to Florence (FLO) ](https://www.expedia.com/lp/flights/mia/flo/miami-to-florence) - [Flights from Wilmington (ILM) to Florence (FLO) ](https://www.expedia.com/lp/flights/ilm/flo/wilmington-to-florence) - [Flights from Raleigh (RDU) to Florence (FLO) ](https://www.expedia.com/lp/flights/rdu/flo/raleigh-to-florence) - [Flights from Savannah (SAV) to Florence (FLO) ](https://www.expedia.com/lp/flights/sav/flo/savannah-to-florence) - [Flights from Memphis (MEM) to Florence (FLO) ](https://www.expedia.com/lp/flights/mem/flo/memphis-to-florence) - [Flights from San Diego (SAN) to Florence (FLO) ](https://www.expedia.com/lp/flights/san/flo/san-diego-to-florence) - [Flights from Sarasota (SRQ) to Florence (FLO) ](https://www.expedia.com/lp/flights/srq/flo/sarasota-to-florence) - [Flights from Denver (DEN) to Florence (FLO) ](https://www.expedia.com/lp/flights/den/flo/denver-to-florence) - [Flights from Seattle (SEA) to Florence (FLO) ](https://www.expedia.com/lp/flights/sea/flo/seattle-to-florence) - [Flights from Pittsburgh (PIT) to Florence (FLO) ](https://www.expedia.com/lp/flights/pit/flo/pittsburgh-to-florence) - [Flights from Detroit (DTW) to Florence (FLO) ](https://www.expedia.com/lp/flights/dtw/flo/detroit-to-florence) - [Flights from Albany (ALB) to Florence (FLO) ](https://www.expedia.com/lp/flights/alb/flo/albany-to-florence) - [Flights from Buffalo (BUF) to Florence (FLO) ](https://www.expedia.com/lp/flights/buf/flo/buffalo-to-florence) - [Flights from Lexington (LEX) to Florence (FLO) ](https://www.expedia.com/lp/flights/lex/flo/lexington-to-florence) - [Flights from Louisville (SDF) to Florence (FLO) ](https://www.expedia.com/lp/flights/sdf/flo/louisville-to-florence) - [Flights from Cleveland (CLE) to Florence (FLO) ](https://www.expedia.com/lp/flights/cle/flo/cleveland-to-florence) - [Flights from Austin (AUS) to Florence (FLO) ](https://www.expedia.com/lp/flights/aus/flo/austin-to-florence) - [Flights from San Francisco (SFO) to Florence (FLO) ](https://www.expedia.com/lp/flights/sfo/flo/san-francisco-to-florence) - [Flights from Greensboro (GSO) to Florence (FLO) ](https://www.expedia.com/lp/flights/gso/flo/greensboro-to-florence) - [Flights from Columbus (CMH) to Florence (FLO) ](https://www.expedia.com/lp/flights/cmh/flo/columbus-to-florence) - [Flights from Richmond (RIC) to Florence (FLO) ](https://www.expedia.com/lp/flights/ric/flo/richmond-to-florence) - 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