Top 10 Hotels in Effingham, SC (from $72) 2026 - Competitive Prices

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Our top choices for Effingham hotels

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

A spacious dining area with multiple tables and chairs, large windows offering a view of the parking lot, and a television mounted on the wall.

1. Howard Johnson by Wyndham Florence

Florence

HOMERO

$65 nightly

$72 total

Sep 29 - Sep 30

Total with taxes and fees

A hotel lobby with a reception desk, seating area, and a television screen.

A hotel room with a bed, a sofa, an ottoman, and a lamp.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A hotel room with a sectional sofa, two ottomans, a bed with a green bedspread, and framed pictures on the wall.

2. Comfort Inn & Suites Florence Center Area

Florence

Mila

$101 nightly

$113 total

Oct 19 - Oct 20

Total with taxes and fees

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

A modern hotel with a 'Park Inn by Radisson' sign, featuring a covered entrance, multiple windows, and a parking lot.

3. Park Inn by Radisson Florence, SC

Florence

Windia

$89 nightly

$100 total

Oct 4 - Oct 5

Total with taxes and fees

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern bar area with a long counter, bar stools, and a variety of bottles and glasses.

A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

A modern lounge area with brick walls, large windows, and contemporary furniture.

4. Hyatt Place Florence Downtown

Florence

Ivette

$110 nightly

$123 total

Oct 5 - Oct 6

Total with taxes and fees

A hotel room with a desk, chair, bed, and a yellow sofa.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

A swimming pool with lounge chairs and a building with balconies.

A hotel dining area with wooden tables and chairs, a fireplace, and a television.

5. Quality Inn & Suites Florence Civic Center

Florence

Noémie

$95 nightly

$107 total

Oct 25 - Oct 26

Total with taxes and fees

An outdoor patio area with tables and chairs, a brick wall, and a glass door leading to the interior.

A spacious living room with hardwood flooring, a staircase, and a large window.

A spacious bar area with a wooden floor, multiple bar stools, and a variety of bottles on shelves.

A spacious lobby with a grand staircase, plush seating, and a modern kitchen area.

6. The Inn at the Crossroads

Lake City

Paige

$110 nightly

$123 total

Sep 29 - Sep 30

Total with taxes and fees

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A modern cafeteria with long wooden tables, green chairs, and yellow accents.

An outdoor patio with a wooden table and wicker chairs, a barbecue grill, and a swimming pool in the background.

7. Spark by Hilton Florence North I-95, SC

Florence

Tienia

$85 nightly

$95 total

Oct 5 - Oct 6

Total with taxes and fees

A hotel room with two beds, a wooden headboard, a window with curtains, and a wall-mounted air conditioner.

An indoor swimming pool with clear blue water, surrounded by green chairs and a tiled floor.

A modern kitchen with a built-in coffee station, a refrigerator, and a seating area with a patterned rug.

8. SpringHill Suites by Marriott Florence

Florence

John

$114 nightly

$127 total

Oct 18 - Oct 19

Total with taxes and fees

A restaurant with brick walls, framed awards, and a bar area.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

A spacious kitchen with a dining area, a living room with a fireplace, and a cozy seating arrangement.

A bar area with a curved counter, multiple stools, and a brick wall backdrop.

9. Hotel Florence, Tapestry Collection by Hilton

Florence

Ankh

$128 nightly

$143 total

Oct 22 - Oct 23

Total with taxes and fees

A Courtyard by Marriott hotel with a covered entrance, multiple floors, and a parking lot.

A hotel room with two beds, a desk, a chair, and a TV.

An indoor swimming pool with clear water, surrounded by tiled walls and a wooden floor. There are chairs and a table near the pool, and large windows allow natural light to enter.

A hotel room with a flat-screen TV, a desk with a chair, a sofa, a small table, and a balcony with outdoor seating.

10. Courtyard by Marriott Florence

Florence

George

$102 nightly

$114 total

Oct 8 - Oct 9

Total with taxes and fees

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

An indoor swimming pool with a tiled floor, a pool ladder, and lounge chairs.

A corner market with shelves stocked with snacks and beverages, and two large refrigerators.

11. Fairfield Inn & Suites by Marriott Florence I-20

Florence

Felecia

$127 nightly

$142 total

Oct 2 - Oct 3

Total with taxes and fees

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A modern office space with a long table, two chairs, a desk with a computer, and a wall-mounted colorful artwork.

A coffee station with two coffee machines and a display of coffee pods and cups.

A modern conference room with red and grey furniture, a blue pillar, and a mounted television on the wall.

12. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

Leigh

$114 nightly

$128 total

Oct 4 - Oct 5

Total with taxes and fees

A building with two red doors, one labeled 'Office' and the other '101'. There is a welcome sign and a mailbox on the wall.

A compact kitchen with a dining area, a TV, and a small table.

A compact living space with a dining area, kitchenette, and seating area.

A house with a stone-paved entrance, a bench, and two red doors labeled "OFFICE" and "PRIVATE."

13. Affordable Suites Florence

Florence

Cheyenne

$84 nightly

$94 total

Oct 5 - Oct 6

Total with taxes and fees

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A reception area with a wooden desk, a map on the wall, and a sign welcoming visitors to Florence, SC.

A modern lounge area with a sofa, armchairs, and small tables.

A self-service beverage station with refrigerated and non-refrigerated drink options, snack shelves, and a sign indicating the location.

14. TownePlace Suites by Marriott Florence

Florence

William

$118 nightly

$132 total

Oct 4 - Oct 5

Total with taxes and fees

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

A hotel room with a bed, sofa, TV, and a desk.

A modern breakfast area with a buffet setup, including a microwave, coffee maker, and various food items.

A La Quinta Inn & Suites hotel with a modern facade, a well-lit entrance, and a landscaped garden area.

15. La Quinta Inn & Suites by Wyndham Florence

Florence

Heather

$89 nightly

$100 total

Oct 5 - Oct 6

Total with taxes and fees

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A Hampton Inn & Suites with a large sign, brick facade, and a parking lot.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

A lobby with a fireplace, seating area, and a television.

16. Hampton Inn & Suites Florence Center

Florence

Bill

$110 nightly

$124 total

Oct 25 - Oct 26

Total with taxes and fees

A hotel room with two beds, a wooden headboard, a nightstand, and three sunset paintings on the wall.

A Days Inn hotel with a modern design, featuring a parking lot and well-maintained landscaping.

A modern kitchen with a central island, a dining area with chairs, a large window with a view of palm trees, and a flat-screen TV mounted on the wall.

A modern hotel room with a large bed, two armchairs, a desk with a computer, and a decorative wall.

17. Days Inn by Wyndham Florence Near Civic Center

Florence

Jefferson

$69 nightly

$77 total

Sep 29 - Sep 30

Total with taxes and fees

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

A hotel room with a sofa, a dining table, a coffee maker, a TV, and artwork on the wall.

A hotel room with a bed, a desk, a TV, a refrigerator, and a painting on the wall.

A conference room with round tables, chairs, and a carpeted floor.

18. Staybridge Suites Florence - Civic Center by IHG

Florence

Tishia

$143 nightly

$160 total

Oct 4 - Oct 5

Total with taxes and fees

A spacious room with a large window, a kitchenette, and two chairs.

A modern office entrance with a glass door, a 'PULL' sign, a reception desk, and a view of the parking area.

A hotel room with a large bed, a nightstand, a wall-mounted light, a painting, and a separate bathroom with a bathtub.

A covered walkway with steps leading to a building.

19. Florence Inn and Suites

Florence

Anthony

$40 nightly

$45 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with two beds, a desk with a TV, and a bathroom visible through an open door.

A large, two-story building with a central entrance flanked by columns, labeled "DIR FRANK B. LEE NURSING BUILDING."

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A hotel reception area with a modern design, including a reception desk, seating area, and a dining section.

20. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Florence

Christopher

$123 nightly

$138 total

Oct 4 - Oct 5

Total with taxes and fees

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Top Effingham Hotel Reviews

Comfort Suites Florence I-95

8/10 Good

"The beds were extremely comfortable, as was the room. Breakfast was served 45 minutes late, and the coffee was terrible."

Spark by Hilton Florence North I-95, SC

10/10 Excellent

"Great customer service,great breakfast"

La Quinta Inn & Suites by Wyndham Florence

8/10 Good

"The romote control was dirty and taped up to keep the batteries in and there was a long hair on my sheets up by the pillow. I understand things happen but they should get fixed as soon as possible. Its was a good comfortable room and the price wasn't too bad. It could use a little more TLC."

TownePlace Suites by Marriott Florence

10/10 Excellent

"The staff is amazing very helpful.."

Hampton Inn & Suites Florence Center

10/10 Excellent

"We loved our stay at the Hampton Inn. The room had plenty of space and was clean. The staff was friendly and they had a lot of options at breakfast. We would definitely stay there again."

Comfort Inn & Suites Florence Center Area

10/10 Excellent

"This property was just off the highway and was super clean. We were not expecting much for a pet friendly hotel which was just off the highway. But it was a very pleasant stay… the staff at the front desk were so friendly and made a great first impression from booking in to belreakfast in the Am.. it was well stocked and kept very clean! Parking was well lit and room was very clean and had shampoo conditioner and body wash and lotion for use!"

Park Inn by Radisson Florence, SC

8/10 Good

"The breakfast was okay for what it was. Room was nice and mostly clean. I believe there was dust and/or mold in the room as it caused sinus issues for both of us staying in the room. Also had one small roach seen on the floor in the bathroom."

Staybridge Suites Florence - Civic Center by IHG

8/10 Good

"Staff was amazing and friendly ! Everyone was so helpful and kind ! Very conveniently located off I-95 and lots of restaurant options ."

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

10/10 Excellent

"The hotel and breakfast was great. Very clean. Not 1 complaint!"

More cheap stays in Effingham

Howard Johnson by Wyndham Florence

2038 W Lucas Street Florence SC

$65 nightly

$72 total

Sep 29 - Sep 30

Total with taxes and fees

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence SC

$69 nightly

$77 total

Sep 29 - Sep 30

Total with taxes and fees

Park Inn by Radisson Florence, SC

1729 Mandeville Road Florence SC

$89 nightly

$100 total

Oct 4 - Oct 5

Total with taxes and fees

9/10 Wonderful! (2,461 reviews)

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC

$95 nightly

$107 total

Oct 25 - Oct 26

Total with taxes and fees

8.4/10 Very Good! (381 reviews)

Comfort Inn & Suites Florence Center Area

527 Woody Jones Blvd Florence SC

$101 nightly

$113 total

Oct 19 - Oct 20

Total with taxes and fees

The Inn at the Crossroads

128 West Main Street Lake City SC

$110 nightly

$123 total

Sep 29 - Sep 30

Total with taxes and fees

Hotels in Effingham with star-rating

Frequently asked questions

What is the best area to stay in Effingham?

The best area to stay in Effingham is near the intersection of US-301 and I-95, as this offers the most convenient access to amenities and onward travel.This area is primarily characterized by its array of hotels, restaurants, and gas stations, strategically located for travelers passing through or needing a stopover. You'll find most services concentrated along US-301, just off the I-95 exits. While not a tourist destination in itself, it provides all the necessary conveniences for a comfortable stay.For solo travelers or couples on a road trip, this location is ideal. It offers quick access to the interstate, making it easy to continue your journey. The concentration of dining options, from casual eateries to sit-down restaurants, provides variety without requiring extensive travel.

When is the best time to go to Effingham?

The best time to visit Effingham, South Carolina, is during the spring (March to May) and fall (September to November) months.These seasons offer pleasant weather with mild temperatures, ideal for enjoying outdoor activities without the intense heat and humidity of summer or the cooler, sometimes unpredictable, temperatures of winter. Spring brings blooming flora, while fall showcases colorful foliage, making for scenic drives and comfortable exploration of the local area.For travelers who prefer warm weather and don't mind higher humidity, the summer months (June to August) are also an option. During this time, the days are long, allowing for extended outdoor enjoyment, though afternoon thunderstorms can occur.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Effingham.

How much is the nightly rate at a Effingham hotel?

Prices for hotels in Effingham often vary, but you can find a great deal from $72 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Find hotels in Effingham, SC from $72

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Effingham

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Effingham hotels

1. Howard Johnson by Wyndham Florence

2. Comfort Inn & Suites Florence Center Area

3. Park Inn by Radisson Florence, SC

4. Hyatt Place Florence Downtown

5. Quality Inn & Suites Florence Civic Center

6. The Inn at the Crossroads

7. Spark by Hilton Florence North I-95, SC

8. SpringHill Suites by Marriott Florence

9. Hotel Florence, Tapestry Collection by Hilton

10. Courtyard by Marriott Florence

11. Fairfield Inn & Suites by Marriott Florence I-20

12. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

13. Affordable Suites Florence

14. TownePlace Suites by Marriott Florence

15. La Quinta Inn & Suites by Wyndham Florence

16. Hampton Inn & Suites Florence Center

17. Days Inn by Wyndham Florence Near Civic Center

18. Staybridge Suites Florence - Civic Center by IHG

19. Florence Inn and Suites

20. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Top Effingham Hotel Reviews

Comfort Suites Florence I-95

Spark by Hilton Florence North I-95, SC

La Quinta Inn & Suites by Wyndham Florence

TownePlace Suites by Marriott Florence

Hampton Inn & Suites Florence Center

Comfort Inn & Suites Florence Center Area

Park Inn by Radisson Florence, SC

Staybridge Suites Florence - Civic Center by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

More cheap stays in Effingham

Howard Johnson by Wyndham Florence

Days Inn by Wyndham Florence Near Civic Center

Park Inn by Radisson Florence, SC

Quality Inn & Suites Florence Civic Center

Comfort Inn & Suites Florence Center Area

The Inn at the Crossroads

Hotels in Effingham with star-rating

Frequently asked questions

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