Find hotels in Effingham, SC from $66
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member Prices
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Effingham
Family friendly
Pet friendly
Check prices for these dates
Our top choices for Effingham hotels
Quality Inn Mullins - Marion
Quality Inn Mullins - MarionMarion
7.8 out of 10, Good, (393 reviews)
"It was ok clean would stay there again. "
jeff
$98 nightly
The price is $107
Apr 3 - Apr 4
Total with taxes and fees
Best Western Executive Inn
Best Western Executive InnLatta
8.2 out of 10, Very Good, (968 reviews)
"Would definitely stay again !!!"
Tracy
$106 nightly
The price is $116
Mar 29 - Mar 30
Total with taxes and fees
Holiday Inn Express & Suites Latta by IHG
Holiday Inn Express & Suites Latta by IHGLatta
9.6 out of 10, Exceptional, (566 reviews)
"Great visit to this site...convenient to food, gas, and the staff was so pleasant. Breakfast was very good and I would not hesitate to stay there again"
Cheryl
$122 nightly
The price is $133
Apr 6 - Apr 7
Total with taxes and fees
Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham FlorenceFlorence
8.6 out of 10, Excellent, (2,593 reviews)
"Was an excellent place to stop for the night on our way to Florida"
Gary
$67 nightly
The price is $75
Mar 23 - Mar 24
Total with taxes and fees
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic CenterFlorence
7.0 out of 10, Good, (1,003 reviews)
"Clean, very quiet , staff very friendly, safe place. "
María
$60 nightly
The price is $68
Mar 24 - Mar 25
Total with taxes and fees
Super 8 by Wyndham Florence
Super 8 by Wyndham FlorenceFlorence
7.0 out of 10, Good, (1,000 reviews)
"Perfect overnight spot"
Martin
$58 nightly
The price is $65
Mar 29 - Mar 30
Total with taxes and fees
Florence Inn and Suites
Florence Inn and SuitesFlorence
6.4 out of 10, (339 reviews)
"Room was super clean, hotel seems newly renovated and super close to the highway "
Tanoya
$56 nightly
The price is $63
Mar 30 - Mar 31
Total with taxes and fees
Comfort Inn & Suites Florence Center Area
Comfort Inn & Suites Florence Center AreaFlorence
9.2 out of 10, Wonderful, (1,233 reviews)
"Clean room, good breakfast...very nice overnight stay."
Gerry
$103 nightly
The price is $115
Mar 29 - Mar 30
Total with taxes and fees
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SCFlorence
9.0 out of 10, Wonderful, (2,230 reviews)
"Staff was helpful and the room/bathroom were very nice."
Diane
$86 nightly
The price is $96
Mar 29 - Mar 30
Total with taxes and fees
Aloft Florence
Aloft FlorenceFlorence
8.6 out of 10, Excellent, (296 reviews)
"Parking is great "
cheto
$103 nightly
The price is $115
Mar 26 - Mar 27
Total with taxes and fees
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic CenterFlorence
8.6 out of 10, Excellent, (32 reviews)
"Clean, quiet and safe location to spend the night. "
David
$93 nightly
The price is $104
Mar 23 - Mar 24
Total with taxes and fees
Best Western Inn
Best Western InnFlorence
7.8 out of 10, Good, (1,002 reviews)
"Very friendly staff. The room was very spacious. "
Arika
$99 nightly
The price is $111
Mar 23 - Mar 24
Total with taxes and fees
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHGFlorence
8.6 out of 10, Excellent, (1,001 reviews)
"The stay was great"
Dianne
$122 nightly
The price is $137
Mar 29 - Mar 30
Total with taxes and fees
Microtel Inn & Suites by Wyndham Florence
Microtel Inn & Suites by Wyndham FlorenceFlorence
6.8 out of 10, (1,004 reviews)
"Friendly staff, clean room, very comfortable bed "
Willie
$61 nightly
The price is $68
Mar 23 - Mar 24
Total with taxes and fees
Days Inn by Wyndham Florence/I-95 North
Days Inn by Wyndham Florence/I-95 NorthFlorence
6.8 out of 10, (1,000 reviews)
"Clean room, friendly staff and ample parking, breakfast is ok. "
Romeo
$59 nightly
The price is $66
Mar 23 - Mar 24
Total with taxes and fees
Hyatt Place Florence Downtown
Hyatt Place Florence DowntownFlorence
9.0 out of 10, Wonderful, (1,002 reviews)
"It was a beautiful room and breakfast was great. Staff was wonderful "
Stephanie
$118 nightly
The price is $132
Mar 30 - Mar 31
Total with taxes and fees
Rodeway Inn Florence Downtown
Rodeway Inn Florence DowntownFlorence
4.8 out of 10, (3 reviews)
"Good"
Joshua
$60 nightly
The price is $67
Mar 29 - Mar 30
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham FlorenceFlorence
8.0 out of 10, Very Good, (1,640 reviews)
"Good hotel"
Eric
$104 nightly
The price is $116
Mar 29 - Mar 30
Total with taxes and fees
Comfort Suites Florence I-95
Comfort Suites Florence I-95Florence
8.4 out of 10, Very Good, (1,004 reviews)
"Love the hotel. "
Blaire
$110 nightly
The price is $123
Apr 19 - Apr 20
Total with taxes and fees
Tru by Hilton Florence I-95
Tru by Hilton Florence I-95Florence
8.4 out of 10, Very Good, (1,002 reviews)
"Everything was great...clean property and friendly staff! "
Lasonia
$101 nightly
The price is $113
Mar 29 - Mar 30
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Effingham Hotel Reviews
Residence Inn Marriott Florence
10/10 Excellent
More cheap stays in Effingham
Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
$59 nightly
The price is $66 total per night from Mar 23 to Mar 24
$66 total
Mar 23 - Mar 24
Total with taxes and fees
6.8/10 (1,000 reviews)
Hotels in Effingham with star-rating
4 Star Hotels
1 properties
Frequently asked questions
Explore a world of travel with Expedia
- Florence Hotels
- Coward Hotels
- Farmstay in Coward
- 3 Star Hotels in Coward
- Hotels near Florence National Cemetery
- Hotels near Florence Museum
- Hotels near Florence Regional
- Hotels near Mcleod Regional Medical Center
- Scranton Hotels
- Hotels near Florence Station
- Cheap Hotels in Florence
- Hotels near Florence Civic Center
- Pet-Friendly Hotels in Florence
- Flights to Coward
- Flights from Florence Regional
- Flights to Florence
- Flights from New York (JFK) to Florence (FLO)
- Flights from Charlotte (CLT) to Florence (FLO)
- Flights from Boston (BOS) to Florence (FLO)
- Flights from Charleston (CHS) to Florence (FLO)
- Flights from St. Louis (STL) to Florence (FLO)
- Flights from Myrtle Beach (MYR) to Florence (FLO)
- Flights from Atlanta (ATL) to Florence (FLO)
- Flights from Nashville (BNA) to Florence (FLO)
- Flights from Las Vegas (LAS) to Florence (FLO)
- Flights from Washington (DCA) to Florence (FLO)
- Flights from Houston (IAH) to Florence (FLO)
- Flights from New York (LGA) to Florence (FLO)
- Flights from Columbia (CAE) to Florence (FLO)
- Flights from Jacksonville (JAX) to Florence (FLO)
- Flights from Chicago (ORD) to Florence (FLO)
- Flights from Baltimore (BWI) to Florence (FLO)
- Flights from Philadelphia (PHL) to Florence (FLO)
- Flights from Hartford (BDL) to Florence (FLO)
- Flights from Tampa (TPA) to Florence (FLO)
- Flights from Greenville (GSP) to Florence (FLO)
- Flights from Dallas (DFW) to Florence (FLO)
- Flights from Rochester (ROC) to Florence (FLO)
- Flights from Orlando (MCO) to Florence (FLO)
- Flights from Oklahoma City (OKC) to Florence (FLO)
- Flights from Huntsville (HSV) to Florence (FLO)
- Flights from Los Angeles (LAX) to Florence (FLO)
- Flights from Phoenix (PHX) to Florence (FLO)
- Flights from Fort Lauderdale (FLL) to Florence (FLO)
- Flights from Miami (MIA) to Florence (FLO)
- Flights from Wilmington (ILM) to Florence (FLO)
- Flights from Raleigh (RDU) to Florence (FLO)
- Flights from Savannah (SAV) to Florence (FLO)
- Flights from Memphis (MEM) to Florence (FLO)
- Flights from San Diego (SAN) to Florence (FLO)
- Flights from Sarasota (SRQ) to Florence (FLO)
- Flights from Denver (DEN) to Florence (FLO)
- Flights from Seattle (SEA) to Florence (FLO)
- Flights from Pittsburgh (PIT) to Florence (FLO)
- Flights from Detroit (DTW) to Florence (FLO)
- Flights from Albany (ALB) to Florence (FLO)
- Flights from Buffalo (BUF) to Florence (FLO)
- Flights from Lexington (LEX) to Florence (FLO)
- Flights from Louisville (SDF) to Florence (FLO)
- Flights from Cleveland (CLE) to Florence (FLO)
- Flights from Austin (AUS) to Florence (FLO)
- Flights from San Francisco (SFO) to Florence (FLO)
- Flights from Greensboro (GSO) to Florence (FLO)
- Flights from Columbus (CMH) to Florence (FLO)
- Flights from Richmond (RIC) to Florence (FLO)
- Flights from Augusta (AGS) to Florence (FLO)
- Flights from Tucson (TUS) to Florence (FLO)
- Flights from Birmingham (BHM) to Florence (FLO)
- Flights from Syracuse (SYR) to Florence (FLO)
- Flights from Chattanooga (CHA) to Florence (FLO)
- Flights from Dayton (DAY) to Florence (FLO)
- Flights from Indianapolis (IND) to Florence (FLO)
- Flights from Norfolk (ORF) to Florence (FLO)
- Flights from Little Rock (LIT) to Florence (FLO)
- Flights from Minneapolis (MSP) to Florence (FLO)
- Flights from Knoxville (TYS) to Florence (FLO)
- Flights from Newburgh (SWF) to Florence (FLO)
- Flights from London (LHR) to Florence (FLO)
- Flights from Daytona Beach (DAB) to Florence (FLO)
- Flights from Milwaukee (MKE) to Florence (FLO)
- Flights from Sacramento (SMF) to Florence (FLO)
- Flights from Colorado Springs (COS) to Florence (FLO)
- Flights from Kansas City (MCI) to Florence (FLO)
- Flights from Providence (PVD) to Florence (FLO)
- Flights from El Paso (ELP) to Florence (FLO)
- Flights from Cincinnati (CVG) to Florence (FLO)
- Flights from West Palm Beach (PBI) to Florence (FLO)
- Flights from New Orleans (MSY) to Florence (FLO)
- Flights from Asheville (AVL) to Florence (FLO)
- Flights from Gainesville (GNV) to Florence (FLO)
- Flights from Missoula (MSO) to Florence (FLO)
- Flights from Lancaster (LNS) to Florence (FLO)
