Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Resorts & Hotels with Spas

See all 399 Hotels in Florida Keys
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (657 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  Sep 11, 2017
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.5 out of 5 (654 reviews)
Love this place, BUTWe've stayed here several times and love everything about it. But this time there was a problem. Irma was coming. The staff said they would get us off the island because our flight was cancelled, and although they made an effort while I was standing there I had to find a way out myself. And when ...
  Sep 13, 2017

$279

$279
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (684 reviews)
Good location Nice overview of the water, easy to conect and central to Duval street.
  Oct 8, 2017

$189

$189
The Cabana Inn Key West

The Cabana Inn Key West

413 Applerouth Lane, Key West
3.0 out of 5.0
4.5 out of 5 (274 reviews)
Close to Duvall stClean, comfortable we really enjoyed our stay nice breakfast, wine and cheese at night, will definitely come back
  Oct 10, 2017

$129

$129
Heron House Court - Adult Only

Heron House Court - Adult Only

412 Frances St, Key West
3.0 out of 5.0
4.3 out of 5 (562 reviews)
A glorious experienceCharming House, a warm welcome, very good breakfast. Located in a quite quartet of KW but within a footwalk to Harbour, shopping and beach
  Oct 7, 2017

$129

$129
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (1,494 reviews)
Nice place and great locationWe enjoyed our stay. They were very accommodating with our flight in and out. The location was perfect.. close to so many things.
  Oct 12, 2017

$319

$319
Seascape Inn

Seascape Inn

420 Olivia Street, Key West
3.0 out of 5.0
4.4 out of 5 (67 reviews)
Nice hotel, great location.We have stayed at the Seascape 4 times. The rooms are nice, they have a continental breakfast, and you can't beat the location. Just steps away from Duval Street.
  Aug 11, 2017

$179

$179
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.0 out of 5.0
4.0 out of 5 (608 reviews)
Great hotel in the center of town near shops and rThe room was lovely and clean. The bed was very comfortable The View out the window is lovely. The staff was very polite. And the pool on the second floor was great
  Oct 16, 2017

$297

$297
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
3.5 out of 5.0
4.1 out of 5 (188 reviews)
Very nice. We'll go back. They've done a great job cleaning up after the hurricane.
  Oct 15, 2017

$136

$136
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,140 reviews)
Nice resort with its own beach and 2 pools We love staying at Hawk's Cay. I love that they have heir own little private beach/lagoon area. Main pool is beautiful, but when you want to get away from other people's kids, there is an adult pool as well. It's a little older but still really nice. My only complaint is that is that the menus have ...
  Sep 17, 2017
Key Largo Bay Marriott Beach Resort

Key Largo Bay Marriott Beach Resort

103800 Overseas Hwy, Key Largo
3.5 out of 5.0
4.2 out of 5 (509 reviews)
Nice hotel with great location and amenities. Hotel staff was very friendly. Will definitely stay again.
  Oct 18, 2017

$178

$178
The Southernmost Inn

The Southernmost Inn

525 United Street, Key West
2.5 out of 5.0
4.0 out of 5 (332 reviews)
Right off Duval Dan was an amazing innkeeper. Helped with our excursion coordination and gave us an excellent breakfast recommendation. Pools and hot tub were great. Within walking distance of all the fun of Duval Street.
  Oct 17, 2017

$139

$139
Key West Marriott Beachside Hotel

Key West Marriott Beachside Hotel

3841 N Roosevelt Blvd, Key West
3.5 out of 5.0
4.4 out of 5 (410 reviews)
couldn't be betterwhat a wonderful experience. The staff, the rooms, the pool. This is the second time I have been to this hotel. When was the last time a hotel greeted you with complimentary champagne, offered complimentary frozen towels on a very hot day as well as free fruit and ice creams at the pool. They take ...
  Sep 1, 2017

$208

$208
Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort

Zero Duval St., Key West
4.6 out of 5 (725 reviews)
Nice Hotel, Great location in the center of it allHotel it’s very clean, and a great location. The only hiccup is I had was the television not working throughout the hotel, and the fire alarm malfunctioning at 2 AM
  Oct 16, 2017

$259

$259
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.1 out of 5 (987 reviews)
Nice hotel. Nice breakfast. Poor beach. Rooms good but need bathroom remodelation. Excellent worker.
  Sep 6, 2017

$289

$289
Banana Bay Resort & Marina

Banana Bay Resort & Marina

4590 Overseas Highway, Marathon
3.0 out of 5.0
3.4 out of 5 (517 reviews)
Stayed there last minuteA group of us were desperately trying to find rooms so we could drive down and volunteer our time to help the victims of Hurricane Irma. I don't think the hotel was prepared to open yet as none of their facilities were open (pool, breakfast included, cable t.v.) due to the damage they received themselves ...
  Sep 28, 2017

$159

$159
Islander Resort, a Guy Harvey Outpost

Islander Resort, a Guy Harvey Outpost

82100 Overseas Highway, Islamorada
3.0 out of 5.0
4.2 out of 5 (673 reviews)
No clean towels for the second day, internet not good. No paper towel either.
  Sep 9, 2017
Hilton Key Largo Resort

Hilton Key Largo Resort

97000 Overseas Hwy, Key Largo
3.5 out of 5.0
3.7 out of 5 (821 reviews)
Small beach but lots to do and hotel grounds were beautiful
  Sep 16, 2017
Holiday Inn Key Largo

Holiday Inn Key Largo

99701 Overseas Hwy, Key Largo
3.0 out of 5.0
3.8 out of 5 (372 reviews)
Very nice hotel with luxuryDuring our stay at the keys, we spend some time in this very nice hotel with all kinds of luxury. A very good place to stay when you look for a hotel.
  Aug 25, 2017

$161

$161
Sunrise Suites Resort

Sunrise Suites Resort

3685 Seaside Drive, Key West
3.0 out of 5.0
3.9 out of 5 (341 reviews)
Great place in the mountains Very nice place. Quite in the mountains. Comfortable it was like home away from home
  Sep 29, 2017

$178

$178
Map

Recently booked Resorts & Hotels with Spas in Florida Keys

Orchid Key Inn
3.5 out of 5.0
Last booking: 1 minute ago
Lighthouse Court Hotel - Key West
3.5 out of 5.0
Last booking: 16 minutes ago
Southwinds Motel
2.0 out of 5.0
Last booking: 43 minutes ago
Hyatt Centric Key West Resort and Spa
4.0 out of 5.0
Last booking: 50 minutes ago
Drop Anchor Resort and Marina
3.0 out of 5.0
Last booking: 1 hour ago
Lime Tree Bay Resort
3.5 out of 5.0
Last booking: 1 hour ago
Smuggler's Cove Resort and Marina
2.5 out of 5.0
Last booking: 1 hour ago
Fairfield Inn and Suites Key West
2.5 out of 5.0
Last booking: 3 hours ago
Silver Palms Inn
3.5 out of 5.0
Last booking: 3 hours ago

Florida Keys Resorts & Spa Travel Guide

Pamper Yourself with a Spa Day in Florida Keys

Pack up your luggage and forget your worries to start your stress-free time-off. If you are looking for fashionable accommodations or reasonable alternatives, we can help you find the ideal location to stay. In fact, this area is so popular that it saw a huge increase of travelers that are making it their perfect spot to unwind. You deserve the royal treatment every now and then. It's time to take a weekend where you can let yourself be unconcerned with everything going on with your life in Florida Keys.

We Have Divine Spa Deals in Florida Keys

There is nothing better than opening the door to your room and realizing all the little things will be taken care for you. Unwind and stretch out for a bit. After that you can book your first appointment to indulge yourself at a nearby spa. After you've indulged yourself by getting a massage treatment, relaxing in the steam room, or lounging poolside, you can put on your explorer's hat and uncover the hidden gems of Florida Keys. Discovering incredible foods, curio shops, or an intriguing museum can be one of the many highlights of your trip. If you're not sure where to begin, stop by your hotel's concierge attendant to get an idea for what Florida Keys has to offer. There is no better source than a local to point you to an exciting evening out or to a cafe to grab a few cocktails at and mingle. Regardless of where you wind up, just be sure to take it easy. Your spa vacation shouldn't be anything but wonderfully relaxing.

Providing plenty of restful retreats and and tranquil surroundings, it's clear why more and more people are choosing Florida Keys as their stress-free spa getaway sanctuary.