Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
4.5/5(3,182 reviews)
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
4/5(980 reviews)
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
4.5/5(760 reviews)
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
$50
per adult
92% of travellers recommend
Key West Sunset Sail with Live Music, Drinks and Appetizers!
$80
per adult
92% of travellers recommend
Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar
$27
per adult
80% of travellers recommend
Miami to Key West Day Trip with Activity Options
$39
per adult
84% of travellers recommend
Lands End Sunset Cruise with Full Bar & Live Music
$75
per adult
90% of travellers recommend
Ultimate 90 minute Sea Doo Jet Ski Tour of Key West -Additional Rider Free!
$129
per traveler
94% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL
Fully refundable
$242 nightly
The price is $272 total per night from Nov 30 to Dec 1
$272 total
Nov 30 - Dec 1
Total with taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,840 reviews)
Billed me for parking when I didn’t have a car. Took several calls to try and resolve. Still haven’t received a refund. They were quick to take my money when I paid for the room but not so responsive in processing my refund.
Reviewed on Nov 1, 2025
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL
$307 nightly
The price is $346 total per night from Nov 16 to Nov 17
$346 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,014 reviews)
Great beach view!
Reviewed on Nov 1, 2025
Southwinds Motel
1321 Simonton Street, Key West, FL
$164 nightly
The price is $185 total per night from Nov 18 to Nov 19
$185 total
Nov 18 - Nov 19
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,223 reviews)
The room wasn't spotless but was still clean. The inside of draws could be vaccumed or wiped down more. Staff was courteous. Heated pool wasn't so heated as they said. For the Queen bedroom, the bathroom toiletries wasn't much as far as soap and shampoo.
Reviewed on Nov 3, 2025
The Southernmost Inn - Adults Only
525 United Street, Key West, FL
$146 nightly
The price is $165 total per night from Nov 10 to Nov 11
$165 total
Nov 10 - Nov 11
Total with taxes and fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,176 reviews)
Great friendly staff. Location is so convenient to Duval street.
Reviewed on Nov 4, 2025
Orchid Key Inn - Adults Only
1004 Duval St, Key West, FL
$286 nightly
The price is $322 total per night from Nov 11 to Nov 12
$322 total
Nov 11 - Nov 12
Total with taxes and fees
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, parking (surcharge), and a 24-hour front desk. Our guests praise the breakfast and the pool in ...
9.8/10 Exceptional! (1,024 reviews)
Very pleased
Reviewed on Nov 3, 2025
Southernmost House
1400 Duval Street, Key West, FL
$402 nightly
The price is $452 total per night from Nov 19 to Nov 20
$452 total
Nov 19 - Nov 20
Total with taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,000 reviews)
Staff was professional, courteous, and responsive. Breakfast was very fresh, well arranged and very delicious!!! Views of the ocean were amazing. The pool was well kept and picturesque! Truly a wonderful experience at a first class, historic facility!
Reviewed on Oct 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(226 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Bahama Village
5/5(38 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.
Key West Historic District
4.5/5(4,033 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Saint Mary Star of the Sea, some noteworthy sights in the nearby area.
Uptown - Upper Duval, FL
Explore a world of travel with Expedia
- Key West Hotels
- All-inclusive Resorts in Key West
- Cheap Hotels in Key West
- Oceanfront Hotels in Key West
- Hotels near Duval Street
- Beach Hotels in Key West
- Adults Only Resorts & in Key West
- Hotels near Key West Historic District
- Houseboats in Key West
- Pet-friendly Hotels in Key West
- Hotels near Southernmost Point
- Condo Rentals in Key West
- Hotels near Tennessee Williams Key West Exhibit
- Hotels near Ernest Hemingway Home and Museum
- Hotels near Key West Butterfly and Nature Conservatory
- Romantic Hotels in Key West
- Family Hotels in Key West
- 4 Star Hotels in Old Town Key West
- Hotels near Old Town Key West
- Hotels near Key West Lighthouse and Keeper's Quarters Museum
- Hotels near MLK Community Pool & Community Center
- 4 Star Hotels in Key West
- Hotels near South Beach
- Hotels near Downtown Key West
- Hilton Hotels in Key West
- 5 Star Hotels in Key West
- Honeymoon Resorts & in Key West
- Hotels near Saint Mary Star of the Sea
- Resorts in Key West
- Hotels near Bahama Village
- Hotels with Restaurants in Bahama Village
- Luxury Hotels in Bahama Village
- 4 Star Hotels in Bahama Village
- Boutique Hotels in Bahama Village
- Resorts & Hotels with Spas in Bahama Village
- Hotels with Bars in Bahama Village
- Golf Hotels in Bahama Village
- Hotels near Simonton Beach
- Boutique Hotels in Key West
- Kimpton Hotels in Key West
- Cabin Rentals in Key West
- Cottages in Key West
- B&B in Key West
- Luxury Hotels in Key West
- Gay friendly Hotels in Key West
- Historic Hotels in Key West
- Hotels with Kitchenettes in Key West
- Hotels with Free Airport Shuttle in Key West
- Guest Houses in Key West
- Best Western Hotels in Key West
- Wyndham Hotels in Key West
- Hotels with smoking rooms in Key West
- Hotels near Key West Firehouse Museum
- Golf Hotels in Key West
- Vacation Homes in Key West
- Hotels with Hot Tubs in Key West
- Hotels with Free Breakfast in Key West
- Villas in Key West
- Hotels with Free Parking in Key West
- 4 Star Hotels in Key West Historic District
- Hyatt Hotels in Key West
- Hostels in Key West
- Key West Vacations
- All inclusive Vacation Packages Key West
- Visit Key West
- Visit Downtown Key West
- Visit Old Town Key West
- Ernest Hemingway Home and Museum
- Visit Bahama Village
- Visit Key West Historic District
- City Zoo Gallery
- South Beach
- Key West Butterfly and Nature Conservatory
- Tennessee Williams Key West Exhibit
- Southernmost Point
- Duval Street
- Key West Lighthouse and Keeper's Quarters Museum
- MLK Community Pool & Community Center
- Old Town Key West Vacations
- Visit Historic Seaport
- Saint Mary Star of the Sea
- Romantic Vacation Packages Key West
- Simonton Beach
- Bahama Village Vacations
- Key West Cemetery
- Car rentals near Key West
- Car rentals near Key West Butterfly and Nature Conservatory
- Car rentals near Southernmost Point
- Car rentals near South Beach
- Car rentals near Duval Street
- Pickup Car Rentals near Duval Street
- SUV Car Rentals near Duval Street
- Hertz Rental Cars in Key West
- Budget Rental Cars in Key West
- Enterprise Rental Cars in Key West
- Mini Car Rentals in Key West