Santa María Vacations from $892

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  • Your Santa María Vacation

    Reserve a Santa María vacation package and get set to experience all this lively city has to offer. Consider basing yourself in the neighborhood of Cartagena Walled City, which is good for views, dining and bars and pubs. San Felipe de Barajas Castle, San Pedro Claver Church and Convent and Jaime Moron Stadium are just a few of the many attractions worth checking out during your trip to Santa María. That dream Santa María vacation is clicks away. Browse hotels, airfares and more on Expedia for a getaway that's tailored to suit your travel style.

    The Latest Santa María Vacation Packages

    Price found within the past 48 hours. Click for updated prices.

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    What to do in Santa María

    Cartagena ATV Tour

    Cartagena ATV Tour

    $115

    per adult

    96% of travelers recommend

    Boat Tour of 5 Must See Points in the Rosario Islands with Lunch

    Cartagena's Rosario Islands 5-Site Boat Tour with Lunch & Snorkel

    $85

    per adult

    82% of travelers recommend

    Enjoy a beautiful sunset

    Luxury Cartagena Sunset Pirate ship Adventure, Cannon Show&Drinks

    $55

    per adult

    88% of travelers recommend

    See all activities in Santa María

    Santa María Hotel Deals

    Wyndham Garden Cartagena

    An outdoor dining area with tables and chairs, a city skyline view, and a wooden ceiling structure.
    • Address: CRA 1 62 69, Cartagena, 130002, CO
    • Location: Urbanizacion Eliana, 0.5 mi from Santa María
    • Star rating: 3.5/5
    • Guest rating: 8.6/10 (Excellent, 1387 reviews)
    • Price: $112 nightly, $112 total, Nov 30 - Dec 1

    Hotel Las Americas Torre del Mar

    A modern infinity pool with clear blue water, lounge chairs, and a view of the ocean.
    • Address: Anillo Vial, Sector Cielo Mar, Torre 2, Cartagena, Bolivar, 130002, CO
    • Location: La Boquilla, 1.7 mi from Santa María
    • Star rating: 4.5/5
    • Guest rating: 9/10 (Wonderful, 1002 reviews)
    • Price: $193 nightly, $193 total, Nov 16 - Nov 17

    Hotel Summer Frente Al Mar

    A deck with lounge chairs and sun loungers, a pool, and a view of the ocean.
    • Address: Vía al Mar, Carrera 9 a #17-20, Cartagena, Bolivar, 130002, CO
    • Location: 1.3 mi from Santa María
    • Star rating: 3/5
    • Guest rating: 8.2/10 (Very good, 671 reviews)
    • Price: $89 nightly, $89 total, Nov 16 - Nov 17
    • Review: Todo excelente muy amable el personal las habitaciones muy limpias excelente comida en el restaurante

    ibis Cartagena Marbella

    A restaurant with high ceilings, pendant lighting, and a mural on the wall. Tables and chairs are arranged for dining.
    • Address: Avenida Santander #47-90, Cartagena, Bolivar, 130002, CO
    • Location: Marbella, 1.2 mi from Santa María
    • Star rating: 3/5
    • Guest rating: 8.4/10 (Very good, 1004 reviews)
    • Price: $61 nightly, $61 total, Dec 12 - Dec 13

    Casa Noa Colonial Rooms

    A dining table with a plate of food, a glass vase with flowers, and a woven placemat.
    • Address: Cl. del Porvenir #6-08, El Centro, Cartagena, Bolívar, 130001, CO
    • Location: Cartagena Centro, 2.4 mi from Santa María
    • Star rating: 2.5/5
    • Guest rating: 9.2/10 (Wonderful, 317 reviews)
    • Price: $64 nightly, $64 total, Nov 18 - Nov 19
    • Review: Perfect location, could even order fruit from the street vendors directly from our balcony and catch our order. AC worked great too!

    Hotel Ayenda Casa Cano 1805

    A hallway with a tiled floor, wooden benches, and hanging plants.
    • Address: Crespo, Calle 69 #4-53, Cartagena, 130002, CO
    • Location: Urbanizacion Eliana, 0.4 mi from Santa María
    • Star rating: 3/5
    • Guest rating: 8.2/10 (Very good, 277 reviews)
    • Price: $43 nightly, $43 total, Nov 19 - Nov 20
    • Review: Very clean and comfortable room. The staff was friendly and attentive. Great value room.

    Varanasi Hotel Boutique

    A swimming pool with a blue tiled edge, surrounded by lush greenery and a blue awning.
    • Address: Calle 70 No.5-69, Cartagena, 130002, CO
    • Location: Crespo, 0.5 mi from Santa María
    • Star rating: 3/5
    • Guest rating: 9.2/10 (Wonderful, 644 reviews)
    • Price: $94 nightly, $94 total, Nov 16 - Nov 17

    Holiday Inn Express Cartagena Manga by IHG

    A modern interior with large windows offering a city view, multiple seating areas, and a wooden floor.
    • Address: Carrera 27 No.28 - 30, Cartagena, 130001, CO
    • Location: Manga, 2.3 mi from Santa María
    • Star rating: 3.5/5
    • Guest rating: 8.8/10 (Excellent, 301 reviews)
    • Price: $93 nightly, $93 total, Dec 14 - Dec 15

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

    See all properties in Santa María

    Frequently Asked Questions

    How much does a Santa María vacation package cost?

    You can grab a vacation package to this top destination from $892 on Expedia. However, how much your vacation to Santa María costs will depend on your hotel choice, length of stay and season.

    What are the cheapest months to go to Santa María?

    You can generally find lower rates and better availability in September, October and December. Explore our cheap Santa María vacation packages and you could land some great off-season discounts.

    How many days is enough for Santa María?

    With a well-organized travel plan, you can easily tick off the main Santa Marían attractions in a few days. But if you prefer to discover hidden spots or take day trips, think about booking your Santa María vacation for longer.

    How to find the best Santa María package deals?

    Landing a cheap Santa María package deal is a breeze with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can tailor your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most affordable Santa María package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.

    Is it cheaper to book a Santa María vacation as a package?

    You can enjoy significant savings on your next Santa Marían escape by booking a customized vacation package. Check the "Package" heading, then enter your destination and travel dates to browse the best hotel and flight prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.

    When to book a vacation package to Santa María?

    If you've got your Santa María vacation dates finalized, book early to grab some fantastic deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.

    How to plan a trip to Santa María?

    1. Pick the ideal time to travel: Your schedule, preferred season and the type of weather you enjoy can all influence your decision on when to go to Santa María.
    2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and food to flights and experiences. Your accommodations will likely be the biggest expense during your trip to Santa María.
    3. Use our trip planning tool to discover Santa María: Research every part of your trip to Santa María with this comprehensive planner. Invite family or friends to collaborate on a group trip, search for hotels or things to do and make bookings.
    4. Decide your trip length: Consider how long you want to spend exploring Santa María. Plan your days so you can get to all the attractions and activities you're interested in at a leisurely pace.
    5. Combine your accommodations and airfare: After you've nailed down your dates and duration, lock in the right Santa María vacation package for you.
    6. Add on experiences and excursions: Have a look at our dedicated travel guide to find some fun things to do in Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

    Does Expedia offer Book Now, Pay Later Santa María vacation packages?

    If you're anything like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa María vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.

    * Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.