Santa María Vacations from $589

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Your Santa María Vacation

Reserve a Santa María vacation package and get set to experience all this lively city has to offer. Consider basing yourself in the neighborhood of Cartagena Walled City, which is good for views, dining and bars and pubs. San Felipe de Barajas Castle, San Pedro Claver Church and Convent and Jaime Moron Stadium are just a few of the many attractions worth checking out during your trip to Santa María. That dream Santa María vacation is clicks away. Browse hotels, airfares and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Med Cartagena

Hotel Med Cartagena

2 out of 5
Save 100% on your flight
Price was $962, price is now $589 per person
$589
per person
Mar 4 - Mar 9
found 13 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
6/10 (3 reviews)
friendly staff and clean rooms

Reviewed on Sep 6, 2025

Casa del Arzobispado Hotel

Casa del Arzobispado Hotel

4 out of 5
Cartagena Walled City
Price was $2,173, price is now $1,090 per person
$1,090
per person
Mar 7 - Mar 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
9.4/10 Exceptional! (316 reviews)
I had a wonderful stay. The hotel and room were lovely. The staff attentive.

Reviewed on Jan 1, 2026

Casa Fernandez by Soho

Casa Fernandez by Soho

2 out of 5
Cartagena Walled City
Save 100% on your flight
Price was $4,054, price is now $2,349 per person
$2,349
per person
Feb 22 - Feb 27
found 20 hours ago
Roundtrip non-stop flight included
New York (NYC) to Cartagena (CTG)
No reviews
Isla Corona

Isla Corona

3 out of 5
Save 100% on your flight
Price was $2,759, price is now $1,626 per person
$1,626
per person
Mar 7 - Mar 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
10/10 Exceptional! (7 reviews)
The place is Amazing, the beach is so beautiful and the people that works there very nice

Reviewed on Jul 28, 2025

Charleston Santa Teresa Cartagena

Charleston Santa Teresa Cartagena

5 out of 5
Cartagena Walled City
Save 100% on your flight
Price was $1,394, price is now $832 per person
$832
per person
Mar 21 - Mar 24
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Cartagena (CTG)
9.4/10 Exceptional! (765 reviews)
Excellent service beautiful hotel

Reviewed on Dec 14, 2025

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Discover the most popular places to visit in Santa María

Bocagrande Beach

Bocagrande Beach

If a restful vacation is part of your travel plans, Bocagrande Beach might be the perfect place to seek out during your trip to Cartagena. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.

Bocagrande Beach
#Island #WhiteSand #Beach #Perfectrion #DreamBeach #IslaPirata

Isla Grande Beach

Why not spend a carefree afternoon at Isla Grande Beach during your travels in Rosario Islands? You can seek out the snorkeling spots in this relaxing area.

Isla Grande Beach
Clock Tower

Clock Tower

You can learn about the history of Cartagena when you stop by Clock Tower. Amble around the area's beautiful beaches or seek out the local tours.

Clock Tower

What to do in Santa María

Cartagena Island Hopping : 5-Stop Rosario Island Tour with Lunch

Cartagena Island Hopping: 5-Stop Rosario Islands Tour with Lunch

$65
per adult
80% of travellers recommend
Cartagena Island Hopping: 5-Stop Rosario Islands Tour with Lunch
Cartagena ATV Tour

Cartagena ATV Tour

$135
per adult
96% of travellers recommend
Cartagena ATV Tour
See all activities in Santa María

Santa María Hotel Deals

Hilton Cartagena

Hilton Cartagena

4.5 out of 5
Avenida Almirante Brion, El Laguito Cartagena
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $188 total per night from Jan 19 to Jan 20
$188 total
Jan 19 - Jan 20
9/10 Wonderful! (1,319 reviews)
Loved it, the staff is super friendly and sweet, The food at the restaurant was amazing and overall a great experience. Would highly recommend

Reviewed on Jan 11, 2026

Hilton Cartagena
ibis Cartagena Marbella

ibis Cartagena Marbella

3 out of 5
Avenida Santander #47-90 Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $70 total per night from Jan 23 to Jan 24
$70 total
Jan 23 - Jan 24
8/10 Very Good! (1,004 reviews)
Simple. Cheap. Convenient.

Reviewed on Jan 11, 2026

ibis Cartagena Marbella
Hyatt Regency Cartagena

Hyatt Regency Cartagena

4.5 out of 5
Carrera 1 No 12-118 Cartagena CO
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $191 total per night from Jan 17 to Jan 18
$191 total
Jan 17 - Jan 18
9.2/10 Wonderful! (1,441 reviews)
Love this hotel

Reviewed on Jan 10, 2026

Hyatt Regency Cartagena
See all 3,766 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Rafael Nunez Intl. Airport (CTG)
Top Sights
Bocagrande Beach, San Felipe de Barajas Castle and Marbella Beach

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Frequently asked questions

How much does a Santa María vacation package cost?
You can grab a vacation package to this top destination from $589 on Expedia. However, how much your vacation to Santa María costs will depend on your hotel choice, length of stay and season.
What are the cheapest months to go to Santa María?
You can generally find lower rates and better availability in September, October and December. Explore our cheap Santa María vacation packages and you could land some great off-season discounts.
How many days is enough for Santa María?
With a well-organized travel plan, you can easily tick off the main Santa Marían attractions in a few days. But if you prefer to discover hidden spots or take day trips, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is a breeze with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can tailor your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most affordable Santa María package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa María vacation as a package?
You can enjoy significant savings on your next Santa Marían escape by booking a customized vacation package. Check the "Package" heading, then enter your destination and travel dates to browse the best hotel and flight prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Santa María?
If you've got your Santa María vacation dates finalized, book early to grab some fantastic deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa María?

  1. Pick the ideal time to travel: Your schedule, preferred season and the type of weather you enjoy can all influence your decision on when to go to Santa María.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and food to flights and experiences. Your accommodations will likely be the biggest expense during your trip to Santa María.
  3. Use our trip planning tool to discover Santa María: Research every part of your trip to Santa María with this comprehensive planner. Invite family or friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide your trip length: Consider how long you want to spend exploring Santa María. Plan your days so you can get to all the attractions and activities you're interested in at a leisurely pace.
  5. Combine your accommodations and airfare: After you've nailed down your dates and duration, lock in the right Santa María vacation package for you.
  6. Add on experiences and excursions: Have a look at our dedicated travel guide to find some fun things to do in Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Santa María vacation packages?
If you're anything like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa María vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.