Santa María Vacations from $957

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Your Santa María Vacation

Reserve a Santa María vacation package and get set to experience all this lively city has to offer. Consider basing yourself in the neighborhood of Cartagena Walled City, which is good for views, dining and bars and pubs. San Felipe de Barajas Castle, San Pedro Claver Church and Convent and Jaime Moron Stadium are just a few of the many attractions worth checking out during your trip to Santa María. That dream Santa María vacation is clicks away. Browse hotels, airfares and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Casa Bali Castillo View Private Pool & R

Casa Bali Castillo View Private Pool & R

Pie del Cerro
Save 100% on your flight
$957
per person
Nov 1 - Nov 6
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
10/10 Exceptional! (1 review)
Excelente ubicación, buenas instalaciones, en la recepción tanto Omar como la recepcionista fueron muy amables en todo momento.

Reviewed on Feb 17, 2026

Hotel Noi 1860 Cartagena

Hotel Noi 1860 Cartagena

Cartagena Walled City
Save 100% on your flight
$1,370
per person
Nov 1 - Nov 8
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
9.2/10 Wonderful! (30 reviews)
Decameron Baru - All inclusive

Decameron Baru - All inclusive

Save 100% on your flight
$1,585
per person
Dec 12 - Dec 16
found 16 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cartagena (CTG)
7.8/10 Good! (402 reviews)
The property it’s very good

Reviewed on Sep 28, 2026

Bora Bora Cartagena

Bora Bora Cartagena

Save 100% on your flight
$1,169
per person
Nov 5 - Nov 11
found 7 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Cartagena (CTG)
9.6/10 Exceptional! (55 reviews)
Room staff everything was very good. And the food of the restaurant was delicious recommend

Reviewed on Sep 14, 2026

Hotel Isla del Sol

Hotel Isla del Sol

Save 100% on your flight
$993
per person
Nov 4 - Nov 11
found 16 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Cartagena (CTG)
9.4/10 Exceptional! (81 reviews)
To start … pulling up to Hotel Del Sol was incredible!! The staff was helpful getting off of the boat. Check in was a breeze. Room was very clean! Beach is unbelievable! Dive off the dock and enjoy the ocean. What I really enjoyed was the gated swim area! Food is unreal, was very surprised on how delicious the food was, given where we were. Food in Colombia was off the chart GREAT! We are coming back in a couple months. I would 100% recommend this place to anyone who wants PARADISE!!! Cheers to the owner and staff. 🤌❤️

Reviewed on Sep 28, 2026

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What to do in Santa María

Enjoy a beautiful sunset

Luxury Cartagena Sunset Pirate ship Adventure, Cannon Show&Drinks

$47
per adult
88% of travellers recommend
Luxury Cartagena Sunset Pirate ship Adventure, Cannon Show&Drinks
Black Lives Matter in the first free land in America, continuing the fight for equality.

Freedom Tour of Palenque

$110
per adult
86% of travellers recommend
Freedom Tour of Palenque
See all activities in Santa María

Santa María Hotel Deals

Hotel Caribe by Faranda Grand, a member of Radisson Individuals

Hotel Caribe by Faranda Grand, a member of Radisson Individuals

Carrera 1a No 2-87 Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$231 nightly
$231 total
Oct 6 - Oct 7
9/10 Wonderful! (1,002 reviews)
"I had a terrible scare when someone banged on my hotel room door—violently and dangerously—while I was asleep; they tried to open the door several times. I called reception more than four times and threatened to call the police before a security guard finally arrived and saw the people who had tried ..."

Reviewed on Sep 30, 2026

Hotel Caribe by Faranda Grand, a member of Radisson Individuals
Sofitel Barú Cartagena

Sofitel Barú Cartagena

KM 7 Sector, Porto Nao Cartagena Bolívar
Fully refundableReserve now, pay when you stay
$324 nightly
$324 total
Oct 12 - Oct 13
9.4/10 Exceptional! (816 reviews)
"We had the most incredible time at Sofitel. The staff were incredibly friendly and helpful, the resort is the perfect place to just stop and relax. It's not too big but the perfect size to make the most of it. They also offer activities throughout the day, we did a pizza making class free of charge. ..."

Reviewed on Sep 28, 2026

Sofitel Barú Cartagena
OZ Hotel Collection

OZ Hotel Collection

6-164 Carrera 2 Cartagena
Fully refundableReserve now, pay when you stay
$100 nightly
$100 total
Oct 4 - Oct 5
9.6/10 Exceptional! (796 reviews)
"Great hotel in Cartagena!"

Reviewed on Sep 30, 2026

OZ Hotel Collection
See all 4,075 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Rafael Nunez Intl. Airport (CTG)
Top Sights
Bocagrande Beach, San Felipe de Barajas Castle and Marbella Beach

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Frequently asked questions

How much does a Santa María vacation package cost?
You can grab a vacation package to this top destination from $957 on Expedia. However, how much your vacation to Santa María costs will depend on your hotel choice, length of stay and season.
What are the cheapest months to go to Santa María?
You can generally find lower rates and better availability in September, October and December. Explore our cheap Santa María vacation packages and you could land some great off-season discounts.
How many days is enough for Santa María?
With a well-organized travel plan, you can easily tick off the main Santa Marían attractions in a few days. But if you prefer to discover hidden spots or take day trips, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is a breeze with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can tailor your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most affordable Santa María package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa María vacation as a package?
You can enjoy significant savings on your next Santa Marían escape by booking a customized vacation package. Check the "Package" heading, then enter your destination and travel dates to browse the best hotel and flight prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Santa María?
If you've got your Santa María vacation dates finalized, book early to grab some fantastic deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa María?
  1. Pick the ideal time to travel: Your schedule, preferred season and the type of weather you enjoy can all influence your decision on when to go to Santa María.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and food to flights and experiences. Your accommodations will likely be the biggest expense during your trip to Santa María.
  3. Use our trip planning tool to discover Santa María: Research every part of your trip to Santa María with this comprehensive planner. Invite family or friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide your trip length: Consider how long you want to spend exploring Santa María. Plan your days so you can get to all the attractions and activities you're interested in at a leisurely pace.
  5. Combine your accommodations and airfare: After you've nailed down your dates and duration, lock in the right Santa María vacation package for you.
  6. Add on experiences and excursions: Have a look at our dedicated travel guide to find some fun things to do in Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
If you're anything like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa María vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.