Santa María Vacations from $479

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Your Santa María Vacation

Reserve a Santa María vacation package and get set to experience all this lively city has to offer. Consider basing yourself in the neighborhood of Cartagena Walled City, which is good for views, dining and bars and pubs. San Felipe de Barajas Castle, San Pedro Claver Church and Convent and Jaime Moron Stadium are just a few of the many attractions worth checking out during your trip to Santa María. That dream Santa María vacation is clicks away. Browse hotels, airfares and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Marazao Beach Hotel & Wellness

Marazao Beach Hotel & Wellness

3 out of 5
Save 100% on your flight
Price was $858, price is now $479 per person
$479
per person
Aug 23 - Aug 28
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cartagena (CTG)
7/10 Good! (8 reviews)
Rooms cleaned daily with a Cozy cabin like ambiance. Food & Drinks Fresh Made to order. Staff Very hospitable and Kind Always willing to assist in every need. They made us feel like Home!

Reviewed on Feb 25, 2026

Soy Local Islawa

Soy Local Islawa

3 out of 5
Save 100% on your flight
Price was $1,383, price is now $700 per person
$700
per person
Aug 23 - Aug 28
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cartagena (CTG)
9/10 Wonderful! (40 reviews)
Loved the peaceful, quiet vibe of the hotel - and the balcony overlooking the sea was wonderful

Reviewed on Jan 7, 2026

Hotel Casa Lola Deluxe Gallery

Hotel Casa Lola Deluxe Gallery

4 out of 5
Cartagena Walled City
Save 100% on your flight
Price was $1,361, price is now $717 per person
$717
per person
Aug 18 - Aug 22
found 5 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cartagena (CTG)
9/10 Wonderful! (528 reviews)
Was ok could be a lot better !

Reviewed on Jun 21, 2026

Casa Bali Castillo View Private Pool & R

Casa Bali Castillo View Private Pool & R

3.5 out of 5
Pie del Cerro
Save 100% on your flight
Price was $1,562, price is now $827 per person
$827
per person
Aug 13 - Aug 17
found 6 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cartagena (CTG)
10/10 Exceptional! (1 review)
Luxury 5BR House W Jacuzzi & Pool

Luxury 5BR House W Jacuzzi & Pool

3 out of 5
Cartagena Walled City
Save 100% on your flight
Price was $2,584, price is now $1,427 per person
$1,427
per person
Sep 4 - Sep 7
found 10 hours ago
Roundtrip non-stop flight included
Miami (MIA) to Cartagena (CTG)
10/10 Exceptional! (1 review)
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What to do in Santa María

Full-Day Volcano of Totumo

Full-Day Volcano of Totumo With Lunch, 5 pools and prívate Bach

$60
per adult
80% of travellers recommend
Full-Day Volcano of Totumo With Lunch, 5 pools and prívate Bach
Cartagena Island Hopping: 5-Stop Rosario Islands Tour with Lunch

Cartagena Island Hopping: 5-Stop Rosario Islands Tour with Lunch

$70
per adult
82% of travellers recommend
Cartagena Island Hopping: 5-Stop Rosario Islands Tour with Lunch
Cartagena ATV Tour

Cartagena ATV Tour

$115
per adult
96% of travellers recommend
Cartagena ATV Tour
See all activities in Santa María

Santa María Hotel Deals

GHL Corales de Indias

GHL Corales de Indias

4 out of 5
Carrera 1 No. 62-198 Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $126 total per night from Jul 13 to Jul 14
$126 total
Jul 13 - Jul 14
GHL Corales de Indias
Hilton Cartagena

Hilton Cartagena

4.5 out of 5
Avenida Almirante Brion, El Laguito Cartagena
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $199 total per night from Jul 14 to Jul 15
$199 total
Jul 14 - Jul 15
9.2/10 Wonderful! (1,451 reviews)
"Cleaning rooms"

Reviewed on Jun 28, 2026

Hilton Cartagena
OZ Hotel Collection

OZ Hotel Collection

4.5 out of 5
6-164 Carrera 2 Cartagena
$100 nightly
The price is $100 total per night from Jul 1 to Jul 2
$100 total
Jul 1 - Jul 2
9.6/10 Exceptional! (575 reviews)
"Had a great experience here. Staff was friendly. The hotel was exceptionally clean. And the breakfast buffet was amazing."

Reviewed on Jun 28, 2026

OZ Hotel Collection
See all 4,065 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Rafael Nunez Intl. Airport (CTG)
Top Sights
Bocagrande Beach, San Felipe de Barajas Castle and Marbella Beach

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Frequently asked questions

How much does a Santa María vacation package cost?
You can grab a vacation package to this top destination from $479 on Expedia. However, how much your vacation to Santa María costs will depend on your hotel choice, length of stay and season.
What are the cheapest months to go to Santa María?
You can generally find lower rates and better availability in September, October and December. Explore our cheap Santa María vacation packages and you could land some great off-season discounts.
How many days is enough for Santa María?
With a well-organized travel plan, you can easily tick off the main Santa Marían attractions in a few days. But if you prefer to discover hidden spots or take day trips, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is a breeze with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can tailor your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Order the results by "Price: low to high" to discover the most affordable Santa María package deals. Want a simple trick to get the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa María vacation as a package?
You can enjoy significant savings on your next Santa Marían escape by booking a customized vacation package. Check the "Package" heading, then enter your destination and travel dates to browse the best hotel and flight prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Santa María?
If you've got your Santa María vacation dates finalized, book early to grab some fantastic deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa María?

  1. Pick the ideal time to travel: Your schedule, preferred season and the type of weather you enjoy can all influence your decision on when to go to Santa María.
  2. Calculate your budget: Ensure you have enough money to pay for everything from transportation and food to flights and experiences. Your accommodations will likely be the biggest expense during your trip to Santa María.
  3. Use our trip planning tool to discover Santa María: Research every part of your trip to Santa María with this comprehensive planner. Invite family or friends to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide your trip length: Consider how long you want to spend exploring Santa María. Plan your days so you can get to all the attractions and activities you're interested in at a leisurely pace.
  5. Combine your accommodations and airfare: After you've nailed down your dates and duration, lock in the right Santa María vacation package for you.
  6. Add on experiences and excursions: Have a look at our dedicated travel guide to find some fun things to do in Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Santa María vacation packages?
If you're anything like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa María vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.