Title: Top Design Hotels in Syros  - Expedia.com

[Syros Travel Guide](https://expedia.com/Syros.dx6143222)[Hotels in Syros](https://expedia.com/Syros-Hotels.d6143222.Travel-Guide-Hotels)[Vacation Rentals in Syros](https://expedia.com/Syros-Vacation-Rentals.d6143222.Travel-Guide-VacationRentals)[Flights to Syros](https://expedia.com/Cheap-Flights-To-Syros.d6143222.Travel-Guide-Flights)[Things to do in Syros](https://expedia.com/Things-To-Do-In-Syros.d6143222.Travel-Guide-Activities)[Car Rentals in Syros](https://expedia.com/Car-Rentals-In-Syros.d6143222.Car-Rental-Guide)[Syros Vacation Packages](https://expedia.com/Syros.d6143222.Destination-Travel-Guides)

![Ermoupolis at Syros island against a blue sky, Greece](https://images.trvl-media.com/place/6143222/a481b1af-89dd-4ad9-846e-0cd474107559.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6143222/a481b1af-89dd-4ad9-846e-0cd474107559.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Check prices for these dates

Tonight

[Mar 24 - Mar 25](https://www.expedia.com/Hotel-Search?regionId=6143222&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 25 - Mar 26](https://www.expedia.com/Hotel-Search?regionId=6143222&startDate=2026-03-25&endDate=2026-03-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6143222&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6143222&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Syros Design Hotels

![Pool](https://images.trvl-media.com/lodging/17000000/16580000/16571400/16571344/1e5425dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/17000000/16580000/16571400/16571344/341bd4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, minibar, in-room safe](https://images.trvl-media.com/lodging/17000000/16580000/16571400/16571344/8b4d674d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/17000000/16580000/16571400/16571344/f7e033d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Myconian Kyma, a Member of Design Hotels

[](https://www.expedia.com/Mykonos-Hotels-Myconian-Kyma-Design-Hotels.h16571344.Hotel-Information)

Mykonos

9.6/10

Exceptional

(290 reviews)

"All staffs of hotel were very kind and helpful. View in breakfast restaurant was excellent."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Woo Hyun

[](https://www.expedia.com/Mykonos-Hotels-Myconian-Kyma-Design-Hotels.h16571344.Hotel-Information)

![Library](https://images.trvl-media.com/lodging/67000000/66780000/66779400/66779304/6c43f569.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Frette Italian sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/67000000/66780000/66779400/66779304/277f131d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/67000000/66780000/66779400/66779304/9f0d5927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside bar](https://images.trvl-media.com/lodging/67000000/66780000/66779400/66779304/d5c7d448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### O by Myconian, Mykonos, a Member of Design Hotels

[](https://www.expedia.com/Mykonos-Hotels-Myconian-O-Hotel.h66779304.Hotel-Information)

Mykonos

9.6/10

Exceptional

(39 reviews)

"Stunning hotel! Great staff "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gabrielle

[](https://www.expedia.com/Mykonos-Hotels-Myconian-O-Hotel.h66779304.Hotel-Information)

![Superior Room Sea Front | Egyptian cotton sheets, premium bedding, free minibar items](https://images.trvl-media.com/lodging/2000000/1070000/1066500/1066475/229466ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1070000/1066500/1066475/611bbf82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1070000/1066500/1066475/a62a23bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room, Sea View (Front View) | Egyptian cotton sheets, premium bedding, free minibar items](https://images.trvl-media.com/lodging/2000000/1070000/1066500/1066475/3fa42bf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mykonos Theoxenia, a Member of Design Hotels

[](https://www.expedia.com/Mykonos-Hotels-Mykonos-Theoxenia-Boutique-Hotel.h1066475.Hotel-Information)

Mykonos

9.4/10

Exceptional

(64 reviews)

"Great location and hotel! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Indya

[](https://www.expedia.com/Mykonos-Hotels-Mykonos-Theoxenia-Boutique-Hotel.h1066475.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08&regionId=6143222&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Top Syros Hotel Reviews

![Harmony Boutique Hotel](https://images.trvl-media.com/lodging/2000000/1920000/1916100/1916074/c46d8a1f_y.jpg)

### Harmony Boutique Hotel

10/10 Excellent

"Had a very enjoyable stay here. The staff and reception were fantastic and always helful"

[](https://expedia.com/Mykonos-Hotels-Harmony-Boutique-Hotel.h1916074.Hotel-Information)

![Semeli Hotel](https://images.trvl-media.com/lodging/1000000/490000/483400/483342/ec133a4a_y.jpg)

### Semeli Hotel

10/10 Excellent

"Everyone was extremely attentive, helpful and sweet. Property is beautiful, clean and walking distance to everything. I highly recommend staying at this hotel! "

[](https://expedia.com/Mykonos-Hotels-Semeli-Hotel.h483342.Hotel-Information)

![Andronikos Hotel - Adults Only](https://images.trvl-media.com/lodging/1000000/120000/114700/114656/1b5b96ae_y.jpg)

### Andronikos Hotel - Adults Only

10/10 Excellent

"Great stay perfect location "

[](https://expedia.com/Mykonos-Hotels-Andronikos-Hotel-Adults-Only.h114656.Hotel-Information)

![Tropicana Hotel , Suites & Villas Mykonos](https://images.trvl-media.com/lodging/22000000/21600000/21593000/21592930/8d709af0_y.jpg)

### Tropicana Hotel , Suites & Villas Mykonos

10/10 Excellent

"Absolutely amazing❤️"

[](https://expedia.com/Mykonos-Hotels-Tropicana-Hotel.h21592930.Hotel-Information)

![Hermes Mykonos Hotel](https://images.trvl-media.com/lodging/5000000/4510000/4508100/4508077/9d1484b5_y.jpg)

### Hermes Mykonos Hotel

10/10 Excellent

"Good location, beautiful views, comfortable rooms, helpful staff."

[](https://expedia.com/Mykonos-Hotels-Hermes-Mykonos-Hotel.h4508077.Hotel-Information)

![Iria Blue Mykonos](https://images.trvl-media.com/lodging/115000000/114650000/114648500/114648472/ab80daf4_y.jpg)

### Iria Blue Mykonos

10/10 Excellent

"The staff were very kind and helpful. The place was clean, only ick was that a cat had pooped down the stairs near our room. And we got harassed a whole night by a stray cat left my children scared to leave the room. The restaurant attached to the hotel has amazing food, I found it was a 100% better than Avli Tou Thodori which people highly recommend. And there is another restaurant close by Nikos which is amazing too. "

[](https://expedia.com/Mykonos-Hotels-Iria-Blue-Mykonos.h114648472.Hotel-Information)

![Nissaki Boutique Hotel](https://images.trvl-media.com/lodging/1000000/700000/695900/695814/c4730ce5_y.jpg)

### Nissaki Boutique Hotel

10/10 Excellent

"Excellent resort "

[](https://expedia.com/Mykonos-Hotels-Nissaki-Boutique-Hotel.h695814.Hotel-Information)

![Poseidon Hotel & Suites](https://images.trvl-media.com/lodging/2000000/1190000/1187200/1187158/ba882c20_y.jpg)

### Poseidon Hotel & Suites

10/10 Excellent

"We loved this hotel and the location. It was perfect. The room was great and very clean, the view was spectacular and the staff were very nice! We would definitely recommend staying here!"

[](https://expedia.com/Mykonos-Hotels-Poseidon-Hotel-Suites.h1187158.Hotel-Information)

![Palladium Hotel](https://images.trvl-media.com/lodging/1000000/530000/527300/527270/bf4fff31_y.jpg)

### Palladium Hotel

10/10 Excellent

"Excellent hotel with great staff!"

[](https://expedia.com/Mykonos-Hotels-Palladium-Hotel.h527270.Hotel-Information)