A coastal town with colorful buildings, a prominent church with a blue dome, and a clear blue sea.

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Check availability on Syros 5 Star Hotels

Tonight
Sep 22 - Sep 23
Tomorrow
Sep 23 - Sep 24
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Syros 5-star hotels

A poolside area with lounge chairs and a view of the sea at night.
A modern bathroom with a large bathtub, wooden flooring, and a view of a cruise ship.
A modern living room with a large rock feature, a white sofa, and a view of the sea.
A modern interior with a wooden floor, white furniture, a large window with a view of the sea, and a balcony with white chairs.

1. CAVO TAGOO MYKONOS

CAVO TAGOO MYKONOS
Mykonos
United States
Aryana
$620 nightly
$723 total
Oct 4 - Oct 5
Total with taxes and fees
CAVO TAGOO MYKONOS
A modern outdoor lounge area with a pool, seating, and a view of the sea.
A woman in a white dress overlooking a coastal town with white buildings and boats in the harbor.
A modern hotel room with a large bed, a desk, and a view of the ocean.
A modern outdoor staircase with integrated lighting, surrounded by potted plants and large vases.

2. Myconian Deos - The Set

Myconian Deos - The Set
Mykonos
United States
Gisela
$348 nightly
$414 total
Oct 22 - Oct 23
Total with taxes and fees
Myconian Deos - The Set
An infinity pool with lounge chairs and a sunset view.
A modern hotel room with a large bed, a flat-screen TV, a ceiling light, and a view of the outdoors.
A cozy lounge area with a large arched window offering a scenic view of the sea and a sunset.
A corridor with a view of the sea and a distant mountain.

3. Myconian Korali Relais & Chateaux

Myconian Korali Relais & Chateaux
Mykonos
United Kingdom
Christopher
$207 nightly
$253 total
Oct 3 - Oct 4
Total with taxes and fees
Myconian Korali Relais & Chateaux
An infinity pool with clear blue water, a white infinity pool edge, and a view of the sea with boats.
A person lounging on a cushioned outdoor seating area with a view of the sea and a distant rocky island.
A modern hotel room with a large bed, a sofa, two round wooden tables, a TV, and a view of the sea and buildings.
A pathway leading to a rocky beach area with white pebbles and agave plants, overlooking the sea.

4. Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux
Mykonos
United States
Monserrat
$175 nightly
$217 total
Oct 21 - Oct 22
Total with taxes and fees
Myconian Ambassador Hotel Relais & Chateaux
A swimming pool with star-shaped lights at night.
A bedroom with a canopy bed, a wooden chair, and a view of the sea.
A marina with multiple yachts docked, rocky coastline, and buildings on the right.
A modern interior with a wooden partition, a chandelier, and a seating area with two white poufs.

5. Palladium Hotel

Palladium Hotel
Mykonos
United States
Edmond
$179 nightly
$220 total
Oct 2 - Oct 3
Total with taxes and fees
Palladium Hotel
A pool with clear blue water and white umbrellas.
A modern hotel room with a view of the ocean, a sitting area with a chair and a small table, and a large mirror on the wall.
A modern bedroom with a large bed, a bathtub, and a view of the sea.
A clear blue pool with a sailboat in the water and a distant shoreline.

6. Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World

Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
Mykonos
United States
Alesia
$338 nightly
$402 total
Oct 1 - Oct 2
Total with taxes and fees
Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
A resort with multiple swimming pools, a beach area with umbrellas, and boats in the water.
A sunlit outdoor seating area with white furniture, a wooden coffee table, and a view of the sea with yachts.
A bedroom with a bed, a desk, and a view of the ocean.

7. Mykonos Blu, A Resort to Live

Mykonos Blu, A Resort to Live
Mykonos
United States
Hagop
$333 nightly
$397 total
Oct 3 - Oct 4
Total with taxes and fees
Mykonos Blu, A Resort to Live
A modern outdoor pool area with lounge chairs and a fire feature.
A restaurant setting with tables set for dining, featuring candlelight and hanging lamps.
An outdoor patio with a modern design, featuring a glass ceiling, seating areas, and a dining setup.
A spacious living room with a sectional sofa, two armchairs, a glass coffee table, and large windows with white shutters.

8. Semeli Hotel

Semeli Hotel
Mykonos
United States
Sonki
$192 nightly
$236 total
Oct 5 - Oct 6
Total with taxes and fees
Semeli Hotel
A pool area with a view of the sea, stone walls, and a hanging chair.
A coastal beach with clear turquoise waters, a sandy shore, and several boats.
A rooftop terrace with a wooden pergola, stone walls, a cushioned seating area, and a view of the ocean.
A modern hotel room with a large bed, a sofa, a flat-screen TV, and a view of the ocean.

9. Tropicana Suites & Villas

Tropicana Suites & Villas
Mykonos
United States
Azmira
$366 nightly
$434 total
Sep 26 - Sep 27
Total with taxes and fees
Tropicana Suites & Villas
A swimming pool with a clear view of the water, a white poolside area, and two empty glasses on a white surface.
A modern building with a stone facade and a clear sky.
A spacious indoor area with a high ceiling, modern chandeliers, and a view of the sea through large windows.
A spacious bedroom with a large bed, a bathroom with a large mirror, and a view of the sea.

10. Nissaki Boutique Hotel

Nissaki Boutique Hotel
Mykonos
United States
Melissa
$214 nightly
$261 total
Sep 29 - Sep 30
Total with taxes and fees
Nissaki Boutique Hotel
A pool with a view of the sea and mountains, a yacht in the distance, and a cactus garden.
A modern interior with a large window offering a coastal view, a wooden table, a cushioned chair, and a fireplace.
A view from a window of a room with a wooden ceiling, a stone wall, and a poolside area with a table and chairs.
A beach with lounge chairs and umbrellas, a woman in a swimsuit walking, and clear blue water.

11. Bill&Coo Mykonos

Bill&Coo Mykonos
Mykonos
Canada
Matthew
$339 nightly
$403 total
Oct 5 - Oct 6
Total with taxes and fees
Bill&Coo Mykonos
A white and blue room with a pool, a white chair, a blue table, and a white umbrella.
An open-plan restaurant with wooden furniture and large windows offering a view of the landscape.
A white building with a red roof, a cross on top, and a large bougainvillea tree in front.
A bedroom with a bed, a desk, a chair, a television, and a view of the outside.

12. San Antonio Summerland

San Antonio Summerland
Mykonos
United States
Charles Edward
$149 nightly
$187 total
Oct 8 - Oct 9
Total with taxes and fees
San Antonio Summerland
A poolside area with lounge chairs, umbrellas, and boats.
A modern bedroom with a large bed, a view of boats and a coastal landscape through a sliding door, and a small table with a chair.
A modern multi-level residential building with multiple swimming pools, outdoor seating areas, and a rooftop garden.
A modern living room with a wooden coffee table, two potted plants, a striped sofa, and a striped pillow.

13. Once in Mykonos - Designed for Adults

Once in Mykonos - Designed for Adults
Mykonos
United States
Dmitry
$299 nightly
$358 total
Oct 2 - Oct 3
Total with taxes and fees
Once in Mykonos - Designed for Adults
A poolside view with a clear blue sea and a mountain in the distance.
A coastal landscape with clear turquoise waters, rocky shoreline, and a sandy beach.
An outdoor dining area with wooden tables and chairs, stone walls, and a view of the sea.
A restaurant with tables and chairs arranged to face a large window overlooking a beach and ocean.

14. Saint John Hotel Villas & Spa

Saint John Hotel Villas & Spa
Mykonos
United States
Nicholas
$179 nightly
$220 total
Oct 11 - Oct 12
Total with taxes and fees
Saint John Hotel Villas & Spa
A poolside dining area with a table set for two, overlooking a pool with a view of the sea and distant hills.
A modern hotel room with a bed, a sofa, a desk, and a TV.
A hotel room with a large bed, a desk, a chair, and a TV. There are large windows with a view of the sea.
A rooftop lounge area with sun loungers, a large tree, and a view of the sea.

15. Grace Mykonos

Grace Mykonos
Mykonos
United States
Lindita
$144 nightly
$181 total
Oct 1 - Oct 2
Total with taxes and fees
Grace Mykonos
A rooftop pool area with seating and a view of the city.
A modern bedroom with a large bed, a small sofa, and a view of the sea.
A modern room with a large window overlooking a pool and a scenic view. There is a dining table with a bottle and a book, and a sofa with cushions.
A modern bedroom with a large bed, a TV, and a view of the sea.

16. Nomia Sunset Suites Mykonos

Nomia Sunset Suites Mykonos
Mykonos
United States
Gabriel
$220 nightly
$268 total
Oct 4 - Oct 5
Total with taxes and fees
Nomia Sunset Suites Mykonos
A poolside area with lounge chairs and a view of the sea.
A bar area with a view of the sea and a hillside.
A poolside area with two lounge chairs and an umbrella, overlooking a calm sea with boats and a hilly landscape in the background.
A resort with a central swimming pool, lounge areas, and a patio with outdoor seating.

17. Kalesma Mykonos

Kalesma Mykonos
Mykonos
United States
Neal
$594 nightly
$694 total
Sep 24 - Sep 25
Total with taxes and fees
Kalesma Mykonos
A modern building with a pool, set against a rocky coastline and the sea.
A modern interior with a water feature, large rocks, and a minimalist design.
A stone building with a flat roof and a large open doorway.
A modern building with multiple levels and balconies, surrounded by large rocks.

18. Armacaas Mykonos Hotel

Armacaas Mykonos Hotel
Mykonos
United States
Yarleny
$172 nightly
$213 total
Oct 4 - Oct 5
Total with taxes and fees
Armacaas Mykonos Hotel
A modern outdoor lounge area with a pool, wooden pergola, and hanging chairs.
A view through an arched doorway with a Buddha statue, a clear blue sky, and the sea.
A beach with yellow and white umbrellas, a sandy area, and a view of the sea and distant mountains.
A bar area with wicker chairs, wooden tables, and pendant lighting.

19. Santa Marina, a Luxury Collection Resort, Mykonos

Santa Marina, a Luxury Collection Resort, Mykonos
Mykonos
United Kingdom
FLORENCE
$560 nightly
$655 total
Oct 6 - Oct 7
Total with taxes and fees
Santa Marina, a Luxury Collection Resort, Mykonos
A modern kitchen with a stone accent wall, wooden cabinets, and a view of the sea.
A modern hotel room with a large bed, a sofa, a dining area, and a view of the city.
A modern gym with exercise equipment, a bench, and a view of the ocean through large windows.
A modern living room with a dining area, a flat-screen TV mounted on the wall, and a cozy seating area with a sofa and a side table.

20. Tinos Beach Hotel

Tinos Beach Hotel
Tinos
Canada
Scott
$177 nightly
$218 total
Sep 23 - Sep 24
Total with taxes and fees
Tinos Beach Hotel
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syros.
Poseidon Hotel & Suites

Poseidon Hotel & Suites

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$147 nightly
$179 total
Oct 2 - Oct 3
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
Poseidon Hotel & Suites
Petasos Beach Resort & Spa, Small Luxury Hotels of the World

Petasos Beach Resort & Spa, Small Luxury Hotels of the World

Platis Yialos Mykonos Mykonos Island
$235 nightly
$279 total
Oct 5 - Oct 6
Total with taxes and fees
Petasos Beach Resort & Spa, Small Luxury Hotels of the World
Mykonos Bay Resort & Villas

Mykonos Bay Resort & Villas

Megali Ammos Mykonos Mykonos Island
$187 nightly
$224 total
Sep 24 - Sep 25
Total with taxes and fees
9.8/10 Exceptional! (655 reviews)
Mykonos Bay Resort & Villas
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syros

Wander through Ermoupoli's neoclassical buildings and marble squares before catching a performance at the historic Apollo Theater. Swim at Galissas beach, then climb the hill to Ano Syros where medieval streets offer spectacular views across the Aegean.

See all hotels in Syros
A cobblestone street lined with colorful buildings, a prominent yellow church with a blue dome, and a clear blue sky.

Top Syros Hotel Reviews

Palladium Hotel

Palladium Hotel

10/10 Excellent
"The staff were amazing."
Kevin 3-night trip
Posted 9 hours ago
Palladium Hotel
Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux

10/10 Excellent
"This is a beautiful top-notch hotel. We were greeted at the door, shown to a quiet sitting area and given a drink while a reception staff member collected our passports and checked us in. Since we were an early morning arrival and our room was not ready, we were shown where we could change and headed up to the pool to relax while we waited for our room to be prepared. The staff assured us our room would be a priority, and true to their word, it was ready for us at 1p. While we waited, we also took lunch at the poolside restaurant. It was fresh and delicious. The restaurant staff then, at lunch, and at breakfast every day could not have been any more accommodating. Speaking of breakfast, what a beautiful simple, clean, but well stocked buffet that included pretty much anything you would like to eat. What I especially appreciated was having my eggs cooked to order, since I follow a strict diet for health reasons. The nightly turn down service, the private pool, and the extra towels delivered to our door are just a few of the additional luxuries provided at this resort. Last, but equally important as all of the above was the kindness and helpfulness of the staff. They booked and cancelled transfers for us at the last minute without a moment’s hesitation. They always had a smile, a warm hello, and were ready to assist at any time. I highly recommend the Myconian Ambassador Hotel. 9/21/2026"
Dolores 2-night trip
Posted 1 day ago
Myconian Ambassador Hotel Relais & Chateaux
Myconian Deos - The Set

Myconian Deos - The Set

10/10 Excellent
"Beautiful property!!! ⭐️⭐️⭐️⭐️⭐️"
John 4-night trip
Posted 9 days ago
Myconian Deos - The Set

Find out more about Syros

Ready to experience the next standard in luxury? We know you're thinking about it. Add even more pleasure on your next trip to Syros by treating yourself to the best of the best when it comes to lodging. It's an ideal pairing. There's no reason to delay a getaway to Syros any longer. You'll join the multitudes of vacationers who have made Syros so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syros and get ready to be pampered like never before.

5-Star Hotels in Syros

You'll have a fantastic time at one of these 5-star hotels. High-end restaurants, excellent customer care, and rejuvenating spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. What kind of amenities will make your stay a wonderful one? A mud wrap treatment that will leave you feeling refreshed and alive? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A full-body massage to help your cares fall away?

But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Syros are waiting for you to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syros 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of the 5-star hotels in Syros today and decompress in total tranquility when you're ready.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Syros?
The amount you pay for a 5-star hotel in Syros depends on factors like when you plan to go and the length of your trip. A top tip for bagging an awesome deal? Use our pricing filters to check out the available hotels for your selected dates.
  • Search for the lowest price per night from $179
What makes a hotel 5 stars in Syros?
From gourmet dining venues and all-day gyms to pools and dreamy bedding, the 5-star experience in Syros is all about indulgence and comfort. But it requires more than just upscale perks to get a 5-star rating. Accommodations also have to offer exceptional services like massage treatments, laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Syros?
Our handy filters are the easiest way to find exactly what you're looking for. Select "All inclusive" and "5-star" to show the finest resorts in Syros where your meals, lodging, activities and entertainment are included in the price. At these escapes, your vacation is pure leisure from the moment you step foot in the lobby.

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