A coastal town with colorful buildings, a prominent church with a blue dome, and a clear blue sea.

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Check availability on Syros 5 Star Hotels

Tonight
Sep 24 - Sep 25
Tomorrow
Sep 25 - Sep 26
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Our top choices for Syros 5-star hotels

A poolside area with lounge chairs and a view of the sea at night.
A modern bathroom with a large bathtub, wooden flooring, and a view of a cruise ship.
A modern living room with a large rock feature, a white sofa, and a view of the sea.
A modern, white-themed living room with a dining area, large windows offering a view of the sea, and a minimalist design.

1. CAVO TAGOO MYKONOS

CAVO TAGOO MYKONOS
Mykonos
United States
Aryana
$635 nightly
$740 total
Oct 5 - Oct 6
Total with taxes and fees
CAVO TAGOO MYKONOS
A modern outdoor lounge area with a pool, seating, and a view of the sea.
A woman in a white dress overlooking a coastal town with white buildings and boats in the harbor.
A modern room with a large window overlooking a body of water and a yacht. There is a sofa, a small round table, and a chair.
A modern outdoor staircase with integrated lighting, surrounded by potted plants and large vases.

2. Myconian Deos - The Set

Myconian Deos - The Set
Mykonos
United States
Gisela
$378 nightly
$447 total
Oct 24 - Oct 25
Total with taxes and fees
Myconian Deos - The Set
An infinity pool with clear blue water, a white infinity pool edge, and a view of the sea with boats.
A person lounging on a cushioned outdoor seating area with a view of the sea and a distant rocky island.
A pathway leading to a rocky beach area with white pebbles and agave plants, overlooking the sea.
A beach with clear turquoise water, a boat, and a person paddleboarding.

3. Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux
Mykonos
United States
Monserrat
$174 nightly
$215 total
Oct 24 - Oct 25
Total with taxes and fees
Myconian Ambassador Hotel Relais & Chateaux
An infinity pool with lounge chairs and a sunset view.
A round table with a vase and two glasses, overlooking a body of water and distant land.
A corridor with a view of the sea and a distant mountain.
A cozy lounge area with a large arched window offering a scenic view of the sea and a sunset.

4. Myconian Korali Relais & Chateaux

Myconian Korali Relais & Chateaux
Mykonos
United Kingdom
Christopher
$206 nightly
$251 total
Oct 3 - Oct 4
Total with taxes and fees
Myconian Korali Relais & Chateaux
A pool area with a view of the sea, stone walls, and a hanging chair.
A coastal beach with clear turquoise waters, a sandy shore, and several boats.
A rooftop terrace with a wooden pergola, stone walls, a cushioned seating area, and a view of the ocean.
A multi-story hotel with stone architecture, a pool area with lounge chairs, and a view of rocky terrain.

5. Tropicana Suites & Villas

Tropicana Suites & Villas
Mykonos
United States
Azmira
$343 nightly
$408 total
Sep 25 - Sep 26
Total with taxes and fees
Tropicana Suites & Villas
A swimming pool with star-shaped lights at night.
A bedroom with a bed, a hanging lamp, a view of a pool, and a seating area with cushions and a bowl of fruit.
A marina with multiple yachts docked, rocky coastline, and buildings on the right.
A bedroom with a canopy bed, a wooden chair, and a view of the sea.

6. Palladium Hotel

Palladium Hotel
Mykonos
United States
Edmond
$177 nightly
$219 total
Oct 3 - Oct 4
Total with taxes and fees
Palladium Hotel
A modern outdoor pool area with lounge chairs and a fire feature.
A modern, multi-level bedroom with a built-in hot tub, white blinds, and a stone wall backdrop.
A spacious living room with a sectional sofa, two armchairs, a glass coffee table, and large windows with white shutters.
An outdoor patio with a modern design, featuring a glass ceiling, seating areas, and a dining setup.

7. Semeli Hotel

Semeli Hotel
Mykonos
United States
Sonki
$183 nightly
$225 total
Oct 5 - Oct 6
Total with taxes and fees
Semeli Hotel
A swimming pool with a clear view of the water, a white poolside area, and two empty glasses on a white surface.
A spacious indoor area with a high ceiling, modern chandeliers, and a view of the sea through large windows.
A waterfront resort with outdoor seating, a pool, and boats in the background.
A spacious bedroom with a large bed, a bathroom with a large mirror, and a view of the sea.

8. Nissaki Boutique Hotel

Nissaki Boutique Hotel
Mykonos
United States
Melissa
$212 nightly
$259 total
Oct 1 - Oct 2
Total with taxes and fees
Nissaki Boutique Hotel
A pool with a view of the sea and mountains, a yacht in the distance, and a cactus garden.
A view from a window of a room with a wooden ceiling, a stone wall, and a poolside area with a table and chairs.
A sunlit outdoor seating area with stone walls, a wooden bench, and a table with a bowl and cup.
A modern interior with a large window offering a coastal view, a wooden table, a cushioned chair, and a fireplace.

9. Bill&Coo Mykonos

Bill&Coo Mykonos
Mykonos
Canada
Matthew
$322 nightly
$383 total
Oct 24 - Oct 25
Total with taxes and fees
Bill&Coo Mykonos
A pool with clear blue water and white umbrellas.
A modern bedroom with a large bed, a bathtub, and a view of the sea.
A seaside dining area with a table set for two, overlooking a coastal town.
A clear blue pool with a sailboat in the water and a distant shoreline.

10. Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World

Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
Mykonos
United States
Alesia
$336 nightly
$400 total
Oct 1 - Oct 2
Total with taxes and fees
Mykonos Riviera Hotel & Spa a member of Small Luxury Hotels of the World
A resort with multiple swimming pools, a beach area with umbrellas, and boats in the water.
A bedroom with a bed, a desk, and a view of the ocean.
A sunlit outdoor seating area with white furniture, a wooden coffee table, and a view of the sea with yachts.

11. Mykonos Blu, A Resort to Live

Mykonos Blu, A Resort to Live
Mykonos
United States
Hagop
$331 nightly
$394 total
Oct 1 - Oct 2
Total with taxes and fees
Mykonos Blu, A Resort to Live
A white and blue room with a pool, a white chair, a blue table, and a white umbrella.
A spacious living area with a wooden ceiling, white sofas, a central coffee table, and potted plants.
An open-plan restaurant with wooden furniture and large windows offering a view of the landscape.
A white building with a red roof, a cross on top, and a large bougainvillea tree in front.

12. San Antonio Summerland

San Antonio Summerland
Mykonos
United States
Charles Edward
$148 nightly
$186 total
Oct 17 - Oct 18
Total with taxes and fees
San Antonio Summerland
A pool area with stone walls and palm trees, leading to a view of the sea.
A modern bathroom with a large window, a bathtub, a towel, and a tray with food items.
A modern outdoor space with a stone wall, a black bathtub, and a seating area with a plant.
A modern bedroom with a large bed, a sitting area, a bathtub, and a view of the sea.

13. Aeonic Suites and Spa

Aeonic Suites and Spa
Mykonos
United States
Lester
$336 nightly
$399 total
Sep 25 - Sep 26
Total with taxes and fees
Aeonic Suites and Spa
A modern outdoor lounge area with a pool, wooden pergola, and hanging chairs.
A view through an arched doorway with a Buddha statue, a clear blue sky, and the sea.
A beach with yellow and white umbrellas, a sandy area, and a view of the sea and distant mountains.
A beachside restaurant with wicker furniture, stone pillars, and umbrellas overlooking the sea.

14. Santa Marina, a Luxury Collection Resort, Mykonos

Santa Marina, a Luxury Collection Resort, Mykonos
Mykonos
$503 nightly
$590 total
Sep 29 - Sep 30
Total with taxes and fees
Santa Marina, a Luxury Collection Resort, Mykonos
A poolside area with lounge chairs and a view of the sea.
A bar area with a view of the sea and a hillside.
A resort with a central swimming pool, lounge areas, and a patio with outdoor seating.
A hotel room with a bed, a chair, a nightstand, a lamp, and a view of the sea.

15. Kalesma Mykonos

Kalesma Mykonos
Mykonos
United States
Neal
$590 nightly
$689 total
Sep 27 - Sep 28
Total with taxes and fees
Kalesma Mykonos
A calm body of water reflecting the sky during sunset.
A seaside terrace with a stone wall, a wooden pergola, and a view of a coastal town.
A modern bar area with a view of the water, wooden furniture, and unique light fixtures.
A bedroom with a large window overlooking a coastal landscape, a bed, a chair, and a small table with a vase.

16. Amazon Mykonos Resort & Spa

Amazon Mykonos Resort & Spa
Mykonos
United States
Mahsa
$218 nightly
$265 total
Oct 3 - Oct 4
Total with taxes and fees
Amazon Mykonos Resort & Spa
A modern hotel with a swimming pool, sun loungers, and a helipad.
A modern architectural design with a central archway, recessed seating areas, and a minimalist aesthetic.
A windmill with a white building in the background.
A table with a clear glass, a rolled-up blueprint, and a white cup with a logo, overlooking a coastal view.

17. Absolute Mykonos Suites & More

Absolute Mykonos Suites & More
Mykonos
$223 nightly
$270 total
Sep 28 - Sep 29
Total with taxes and fees
Absolute Mykonos Suites & More
A modern building with a pool, set against a rocky coastline and the sea.
A modern building with multiple levels and balconies, surrounded by large rocks.
A bedroom with a bed, a lamp, a door, and a window.
A modern interior with a water feature, large rocks, and a minimalist design.

18. Armacaas Mykonos Hotel

Armacaas Mykonos Hotel
Mykonos
United States
Yarleny
$156 nightly
$195 total
Oct 2 - Oct 3
Total with taxes and fees
Armacaas Mykonos Hotel
A serene pool area with a clear view of the mountains, modern outdoor seating, and a well-lit building.
A modern building with a stone facade, a wooden lattice entrance, and a well-lit interior.
A room with a view of the sea, a round table, two chairs, and a ceiling with wooden slats.
A modern living room with a large arched window, comfortable seating, and decorative elements.

19. Myconian Naia - Preferred Hotels & Resorts

Myconian Naia - Preferred Hotels & Resorts
Mykonos
United States
shahram
Myconian Naia - Preferred Hotels & Resorts
A luxurious outdoor dining area with wicker chandeliers, palm trees, and a pool overlooking a marina.
A bedroom with a large bed, a mirror, and a view of an outdoor area with plants and a chair.
A bar area with wicker chairs and a poolside seating area.
A seaside restaurant with wicker furniture, tables set with glasses and plates, and umbrellas providing shade.

20. O by Myconian, Mykonos, a Member of Design Hotels

O by Myconian, Mykonos, a Member of Design Hotels
Mykonos
United States
Sahar
$345 nightly
$410 total
Oct 3 - Oct 4
Total with taxes and fees
O by Myconian, Mykonos, a Member of Design Hotels
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syros.
Poseidon Hotel & Suites

Poseidon Hotel & Suites

Mykonos Town Mykonos Mykonos Island
$146 nightly
$178 total
Oct 3 - Oct 4
Total with taxes and fees
Poseidon Hotel & Suites
Hermes Mykonos Hotel

Hermes Mykonos Hotel

Mykonos Town Mykonos Mykonos Island
$131 nightly
$161 total
Oct 5 - Oct 6
Total with taxes and fees
Hermes Mykonos Hotel
Giannoulaki Resort

Giannoulaki Resort

Glastros Mykonos Mykonos Island
$91 nightly
$115 total
Sep 25 - Sep 26
Total with taxes and fees
Giannoulaki Resort
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syros

Wander through Ermoupoli's neoclassical buildings and marble squares before catching a performance at the historic Apollo Theater. Swim at Galissas beach, then climb the hill to Ano Syros where medieval streets offer spectacular views across the Aegean.

See all hotels in Syros
A cobblestone street lined with colorful buildings, a prominent yellow church with a blue dome, and a clear blue sky.

Top Syros Hotel Reviews

Myconian Deos - The Set

Myconian Deos - The Set

10/10 Excellent
"Elegant amenities Peaceful ambiance delicious food and wonderful bar Yet close enough to the scene nearby Attention to detail We are discerning travelers. This one ranks!"
victoria 3-night trip
Posted 3 hours ago
Myconian Deos - The Set
Palladium Hotel

Palladium Hotel

10/10 Excellent
"I started my holiday at the Palladium Hotel in Mykonos and returned to it at the end of my holiday. I was greeted on arrival with a glass of bubbly. In the same way that they upgraded my room on my first visit, my room was upgraded again this time to a room with my own private pool. I extended my stay by an extra day because I was celebrating a new job, and they allowed to remain in the same room. Once again the service was beyond my expectations, nothing was too much for anyone. Everyone went out of their way to ensure I had a wonderful experience. The hotel is stylish and beautifully decorated. The rooms are relaxing and comfortable. But it is really the staff who made the stay so good. I visit Mykonos regularly and regret not discovering Palladium sooner. I don't have to think about where I will stay next time I visit. It will definitely be Palladium."
Hazel 1-night trip
Posted 22 hours ago
Palladium Hotel
Tropicana Suites & Villas

Tropicana Suites & Villas

10/10 Excellent
"My husband and I really LOVED our stay here. Staff was incredibly helpful and kind and accommodated all of our needs. We were more than appreciative for how great everything was. We definitely hope to be back soon!!! Also incredible pool and views love the easy access to the beach"
Nicole 3-night trip
Posted 1 day ago
Tropicana Suites & Villas
Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux

10/10 Excellent
"This is a beautiful top-notch hotel. We were greeted at the door, shown to a quiet sitting area and given a drink while a reception staff member collected our passports and checked us in. Since we were an early morning arrival and our room was not ready, we were shown where we could change and headed up to the pool to relax while we waited for our room to be prepared. The staff assured us our room would be a priority, and true to their word, it was ready for us at 1p. While we waited, we also took lunch at the poolside restaurant. It was fresh and delicious. The restaurant staff then, at lunch, and at breakfast every day could not have been any more accommodating. Speaking of breakfast, what a beautiful simple, clean, but well stocked buffet that included pretty much anything you would like to eat. What I especially appreciated was having my eggs cooked to order, since I follow a strict diet for health reasons. The nightly turn down service, the private pool, and the extra towels delivered to our door are just a few of the additional luxuries provided at this resort. Last, but equally important as all of the above was the kindness and helpfulness of the staff. They booked and cancelled transfers for us at the last minute without a moment’s hesitation. They always had a smile, a warm hello, and were ready to assist at any time. I highly recommend the Myconian Ambassador Hotel. 9/21/2026"
Dolores 2-night trip
Posted 3 days ago
Myconian Ambassador Hotel Relais & Chateaux

Find out more about Syros

Ready to experience the next standard in luxury? We know you're thinking about it. Add even more pleasure on your next trip to Syros by treating yourself to the best of the best when it comes to lodging. It's an ideal pairing. There's no reason to delay a getaway to Syros any longer. You'll join the multitudes of vacationers who have made Syros so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syros and get ready to be pampered like never before.

5-Star Hotels in Syros

You'll have a fantastic time at one of these 5-star hotels. High-end restaurants, excellent customer care, and rejuvenating spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. What kind of amenities will make your stay a wonderful one? A mud wrap treatment that will leave you feeling refreshed and alive? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A full-body massage to help your cares fall away?

But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Syros are waiting for you to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syros 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of the 5-star hotels in Syros today and decompress in total tranquility when you're ready.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Syros?
The amount you pay for a 5-star hotel in Syros depends on factors like when you plan to go and the length of your trip. A top tip for bagging an awesome deal? Use our pricing filters to check out the available hotels for your selected dates.
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What makes a hotel 5 stars in Syros?
From gourmet dining venues and all-day gyms to pools and dreamy bedding, the 5-star experience in Syros is all about indulgence and comfort. But it requires more than just upscale perks to get a 5-star rating. Accommodations also have to offer exceptional services like massage treatments, laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Syros?
Our handy filters are the easiest way to find exactly what you're looking for. Select "All inclusive" and "5-star" to show the finest resorts in Syros where your meals, lodging, activities and entertainment are included in the price. At these escapes, your vacation is pure leisure from the moment you step foot in the lobby.

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