Title: Visit East Prairie: 2026 Travel Guide for East Prairie, Missouri | Expedia.com [Hotels in East Prairie](https://expedia.com/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Vacation Rentals in East Prairie](https://expedia.com/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[Car Rentals in East Prairie](https://expedia.com/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.com/East-Prairie.d3000349349.Destination-Travel-Guides) # East Prairie, MO ## Travel Guide ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit East Prairie Things to do ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_3000349349) - East Prairie Hotel Deals - Vacation Rentals in East Prairie ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO $94 nightly $108 total Mar 15 - Mar 16 Total with taxes and fees Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ... 9.4/10 Exceptional! (1,000 reviews) Everything and everyone were wonderful at this Drury Inn! Very clean rooms and common areas, helpful, positive staff, fun indoor/outdoor pool area with towels, and breakfast and evening snacks and drinks all included in a great price! What a deal! Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=3000349349) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO $95 nightly $108 total Mar 22 - Mar 23 Total with taxes and fees Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ... 9/10 Wonderful! (498 reviews) East, friendly check in. Beautiful, large room. Reviewed on Mar 9, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F22%2F2026&endDate=3%2F23%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=3000349349) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO $82 nightly $93 total Mar 26 - Mar 27 Total with taxes and fees Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ... 8.4/10 Very Good! (1,007 reviews) nice and covenant have stay here a few times, staff always has a smile. Reviewed on Mar 10, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=3000349349) [See all 86 properties in East Prairie](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F12%2F2026&endDate=3%2F13%2F2026®ionId=3000349349) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/d93cc56b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Duck Hunting, Fishing or Relaxing Family Vacation Hornbeak TN Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ... 10/10 Exceptional! (222 reviews) Everything was perfect we loved it so much! Can’t wait for next visit Boyettes has AMAZING food if you are looking for somewhere to eat or just cook here Jason has absolutely everything you may need to cook any meal you can think of! Fish cleaning and duck cleaning stations are going to be your best ... Reviewed on Mar 10, 2026 [](https://expedia.com/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information) ![Come and relax at the Refuge at beautiful Reelfoot Lake!](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/0a58d14b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Come and relax at the Refuge at beautiful Reelfoot Lake! Hornbeak TN Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby. 9.4/10 Exceptional! (26 reviews) Everything was great Reviewed on Feb 15, 2026 [](https://expedia.com/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information) ![3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/5c6ff00e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters Hornbeak TN Stay at this vacation home in Hornbeak. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ... 10/10 Exceptional! (5 reviews) The host and house were great! I definitely recommend staying at this house! Reviewed on Feb 9, 2026 [](https://expedia.com/Hornbeak-Hotels-3-Bedroom-House-On-Reelfoot-Lake.h123259172.Hotel-Information) [See all properties in East Prairie](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000349349&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check East Prairie hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-03-11&endDate=2026-03-12)[Mar 11 - Mar 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-03-11&endDate=2026-03-12) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-03-12&endDate=2026-03-13)[Mar 12 - Mar 13](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-03-12&endDate=2026-03-13) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)[Mar 13 - Mar 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026) ### Popular places to visit #### Big Oak Tree State Park 4.5/5(3 reviews) You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. [](https://expedia.com/Big-Oak-Tree-State-Park-East-Prairie.d553248621532655754.Vacation-Attraction) ## Cities near East Prairie ![Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky. ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Charleston ![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Sikeston ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Bertrand Hotels ](https://www.expedia.com/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels) - [Motels in Bertrand ](https://www.expedia.com/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation) - [4 Star Hotels in Bertrand ](https://www.expedia.com/4Star-Bertrand-Hotels.s40-0-d3000349285.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Bertrand ](https://www.expedia.com/3Star-Bertrand-Hotels.s30-0-d3000349285.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Bertrand ](https://www.expedia.com/5Star-Bertrand-Hotels.s50-0-d3000349285.Travel-Guide-Filter-Hotels) - 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