East Prairie, MO
Travel Guide
Visit East Prairie
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from May 12 to May 13
$128 total
May 12 - May 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,007 reviews)
Nice stay staff and amenities were exe
Reviewed on May 6, 2026
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
$102 nightly
The price is $115 total per night from May 17 to May 18
$115 total
May 17 - May 18
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (555 reviews)
Clean Friendly staff Quiet Convenient
Reviewed on May 5, 2026
Best Western Plus Sikeston I-55
120 S Interstate Drive Sikeston MO
$81 nightly
The price is $92 total per night from May 20 to May 21
$92 total
May 20 - May 21
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
Have more then 1 waffle maker during breakfast rush would be a good idea
Reviewed on May 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters
Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (8 reviews)
We had the best weekend ! Jessica was so friendly , and we loved seeing her pup ! We will definitely be back .
Reviewed on May 5, 2026
Duck Hunting, Fishing or Relaxing Family Vacation
Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (230 reviews)
Lake access and view of the lake was fantastic house was great as well as location!!!Jason was very friendly and extremely helpful!
Reviewed on Apr 18, 2026
Come and relax at the Refuge at beautiful Reelfoot Lake!
Hornbeak TN
Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby.
9.4/10 Exceptional! (28 reviews)
Everything was just what we needed. Perfect weekend
Reviewed on Mar 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Big Oak Tree State Park
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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- Mississippi River
- Ohio River
- Reelfoot Lake
- Reelfoot Lake State Park
- Discovery Park of America
- Ohio River Valley
- Columbus-Belmont State Park
- Sikeston Depot Museum
- Fort Defiance State Park
- Campbell's Point
- Union City Masquerade Theatre
- Central Park
- Marston Community Center
- Graham Park
- New Madrid Historical Museum
- Hunter-Dawson State Historic Site
