Find hotels in Medical Center Area, Boston from $142

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Discover 3,721 Medical Center Area hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

The Inn at Longwood Medical

3.5 star property
8.4 out of 10, Very Good, (1009)
"Perfect location for families of patients at Brigham and Women’s Hospital. Two block walk on a well lit and traveled street."
$305 nightly
The price is $355
Jul 26 - Jul 27
Total includes taxes and fees
The Inn at Longwood Medical

Encore Boston Harbor

5.0 star property
9.6 out of 10, Exceptional, (3143)
"Great place to stay "
$307 nightly
The price is $343
Aug 25 - Aug 26
Total includes taxes and fees
Encore Boston Harbor

Archer Hotel Boston/Burlington

4.0 star property
9.6 out of 10, Exceptional, (1011)
"Best hotel stay!"
$169 nightly
The price is $189
Jul 26 - Jul 27
Total includes taxes and fees
Archer Hotel Boston/Burlington

Oasis Guest House

2.5 star property
9.6 out of 10, Exceptional, (1228)
"Lovely guesthouse in Boston. Would stay again. "
$158 nightly
The price is $181
Aug 24 - Aug 25
Total includes taxes and fees
Oasis Guest House

Canopy By Hilton Boston Downtown

4.0 star property
9.6 out of 10, Exceptional, (1006)
"Great hotel. Great location"
$229 nightly
The price is $266
Aug 24 - Aug 25
Total includes taxes and fees
Canopy By Hilton Boston Downtown

Seaport Hotel Boston

4.0 star property
9.6 out of 10, Exceptional, (3118)
"Great stay"
$242 nightly
The price is $281
Jul 27 - Jul 28
Total includes taxes and fees
Seaport Hotel Boston

citizenM Boston Back Bay

4.0 star property
9.4 out of 10, Exceptional, (1492)
"Great stay"
$189 nightly
The price is $220
Aug 10 - Aug 11
Total includes taxes and fees
citizenM Boston Back Bay

The Godfrey Hotel Boston

4.0 star property
9.4 out of 10, Exceptional, (4209)
"Really enjoyed our stay. "
$219 nightly
The price is $255
Aug 24 - Aug 25
Total includes taxes and fees
The Godfrey Hotel Boston

The Lenox Hotel Boston

4.5 star property
9.6 out of 10, Exceptional, (1085)
"Love everything about this hotel. Great location, friendly staff, and room was perfect. We’ll definitely stay here again!"
$345 nightly
The price is $402
Jul 27 - Jul 28
Total includes taxes and fees
The Lenox Hotel Boston

The Dagny Boston

4.0 star property
9.4 out of 10, Exceptional, (6184)
"perfect proximity to all the tourist sites!"
$228 nightly
The price is $266
Aug 24 - Aug 25
Total includes taxes and fees
The Dagny Boston

Aloft Framingham

3.0 star property
9.4 out of 10, Exceptional, (563)
"This hotel was spacious and the staff were very friendly. The sitting area outside was great and perfect for everything we wanted to do. "
$127 nightly
The price is $142
Aug 20 - Aug 21
Total includes taxes and fees
Aloft Framingham

Hotel 1868

3.5 star property
9.4 out of 10, Exceptional, (1006)
"Very well located and nice rooms."
$178 nightly
The price is $206
Aug 11 - Aug 12
Total includes taxes and fees
Hotel 1868

InterContinental Boston by IHG

5.0 star property
9.2 out of 10, Wonderful, (1015)
"Excellent stay, highly recommend "
$270 nightly
The price is $315
Aug 24 - Aug 25
Total includes taxes and fees
InterContinental Boston by IHG

Hotel Commonwealth

4.5 star property
9.4 out of 10, Exceptional, (1682)
"Had a great stay "
$379 nightly
The price is $441
Aug 10 - Aug 11
Total includes taxes and fees
Hotel Commonwealth

citizenM Boston North Station

4.0 star property
9.2 out of 10, Wonderful, (3582)
"Great place to stay! "
$174 nightly
The price is $203
Aug 24 - Aug 25
Total includes taxes and fees
citizenM Boston North Station

Omni Boston Hotel at the Seaport

4.0 star property
9.2 out of 10, Wonderful, (3721)
"Beautiful hotel and great location!"
$218 nightly
The price is $254
Aug 24 - Aug 25
Total includes taxes and fees
Omni Boston Hotel at the Seaport

Boston Harbor Hotel

5.0 star property
9.8 out of 10, Exceptional, (1010)
"Great hotel terrific staff"
$563 nightly
The price is $656
Aug 8 - Aug 9
Total includes taxes and fees
Boston Harbor Hotel

The Verb Hotel

3.5 star property
9.6 out of 10, Exceptional, (1786)
"Fun place!"
$289 nightly
The price is $337
Jul 28 - Jul 29
Total includes taxes and fees
The Verb Hotel

Hotel AKA Back Bay

4.5 star property
9.2 out of 10, Wonderful, (1111)
"Great stay "
$285 nightly
The price is $332
Aug 24 - Aug 25
Total includes taxes and fees
Hotel AKA Back Bay

Hyatt Regency Boston Harbor

4.0 star property
9.2 out of 10, Wonderful, (1536)
"Great Staff and Great View of the Boston Harbor!"
$225 nightly
The price is $262
Aug 10 - Aug 11
Total includes taxes and fees
Hyatt Regency Boston Harbor
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center Area

Find the best Medical Center Area areas and neighborhoods for the activities you enjoy most.
Downtown Boston map

Downtown Boston

Densely packed with highrise buildings, this area boasts landmarks like Custom House Tower and is close to Quincy Market, Faneuil Hall, and the Old State House. Find headquarters of major banks, hotels, and investment firms here.

Back Bay map

Back Bay

Victorian brownstone homes and cultural institutions like the Boston Public Library define this area. Shop at Newbury Street, Prudential Center, and Copley Place, or explore sights like Trinity Church and the John Hancock Tower.

Seaport District map

Seaport District

Experience a transformed industrial area with office towers, innovation labs, and 78 restaurants. Visit the Institute of Contemporary Art and easily access Downtown Boston via the Evelyn Moakley Bridge.

Beacon Hill map

Beacon Hill

Historic Federal-style rowhouses, gaslit streets, and brick sidewalks create a charming atmosphere. Explore the Boston African American National Historic Site, shop on Charles Street, and easily access MBTA stations.

North End map

North End

Indulge in Italian cuisine at numerous restaurants and bakeries, explore historic sites like Old North Church and Paul Revere House, and enjoy performances at NEMPAC and Improv Asylum Theater. Easily accessible via MBTA lines, buses, and ferries.

Top Medical Center Area Hotel Reviews

Frequently asked questions

What are the best hotels in Medical Center Area that travelers recommend?
The Verb Hotel is a great choice in the Medical Center Area, boasting an impressive review score of 9.8. This vibrant hotel features an outdoor pool where families can unwind after a day of exploring, along with a poolside bar superb for parents looking to relax. The inviting space is enhanced by thoughtful amenities such as complimentary breakfast and accessible parking, making it a convenient option for all travelers. Guests rave about its unique design and historical district location, offering a fun and engaging experience for everyone.

Families will find The Lenox Hotel Boston to be a fantastic option, also rated at 9.6. This hotel goes above and beyond with its in-room babysitting services and child-friendly features. Parents can enjoy a 24-hour fitness center while kids are entertained, and the hotel's central location makes it easy to explore nearby attractions. The complimentary amenities, like cribs and rollaway beds, ensure a stress-free stay for families visiting the bustling Medical Center Area.

Couples looking for a romantic getaway should consider the elegant stay of The Eliot Hotel, which has a rating of 9.6. With features like champagne service and a nearby historical district, this hotel sets the superb stage for a memorable experience. The luxurious suites and designer toiletries add a touch of sophistication, making it an ideal retreat for those celebrating special occasions.

For business travelers, the Four Seasons Hotel One Dalton Street, Boston, is a top-tier choice with a rating of 9.6. Equipped with a 24-hour business center and multiple meeting rooms, it caters superbly to those on work trips. After a long day, guests can indulge in the onsite full-service spa or take a dip in the indoor pool to unwind in style.

Each of these hotels in the Medical Center Area promises exceptional service and a range of amenities tailored to meet the diverse needs of travelers, ensuring a memorable stay for all.
What are the best family hotels in Medical Center Area?
The Lenox Hotel Boston stands out as a family-friendly gem in the Medical Center Area, boasting a remarkable traveler review score of 9.6. This hotel goes above and beyond for families, offering amenities such as in-room babysitting, connecting rooms for larger groups, and complimentary cribs. The thoughtful inclusion of extra rollaway beds ensures everyone has a cozy place to rest after a day of adventures.

Another fantastic option is The Verb Hotel, which has earned an impressive rating of 9.8. With a vibrant atmosphere, this hotel features a refreshing pool that kids will love. Families appreciate the free amenities for children, making it a delightful choice for those traveling with little ones.

The Eliot Hotel also shines with a strong review score of 9.6, providing connecting rooms for family convenience and complimentary cribs. This hotel offers a spacious layout superb for families seeking comfort and ease during their stay.

For an upscale experience, the Four Seasons Hotel One Dalton Street, Boston, rated 9.6, presents a luxurious escape with a family-friendly touch. The hotel offers connecting rooms, a pool, and even a restaurant that caters to children's dining preferences, making it a fabulous choice for families wanting a touch of elegance.

Lastly, Hotel Commonwealth, with a review score of 9.4, ensures families feel at home with free cribs, rollaway beds, and child-friendly window designs. This property is tailored for family comfort while being conveniently located near the Medical Center Area.
What are the best 5-star hotels in Medical Center Area?
The Four Seasons Hotel One Dalton Street, Boston, rated an impressive 9.6 by guests, stands as a beacon of luxury in the Medical Center Area. This 5-star sanctuary offers an exquisite blend of modern elegance and top amenities, making it an ideal choice for couples seeking a romantic getaway or special occasion. Imagine indulging in rejuvenating spa treatments in the couples' treatment rooms, followed by a dip in the tranquil indoor pool, all while enjoying the attentive service that Four Seasons is renowned for.

For those who appreciate exclusivity, the Raffles Boston also boasts a stellar rating of 9.6. This splendid hotel features a full-service spa that includes a hot tub and steam room, great for unwinding after a day of exploring the city. Couples can enjoy luxurious evenings by the fireplace in their premium rooms, complete with designer toiletries and deep soaking bathtubs, providing a great setting for relaxation and intimacy.

Meanwhile, the Mandarin Oriental, Boston, with an impressive review score of 9.4, offers an array of spa treatments that cater to every need, from Swedish massages to hydrotherapy treatments. The on-site health club and yoga classes ensure that your wellness routine continues seamlessly during your stay. With its luxurious accommodations featuring Frette Italian sheets and premium bedding, this hotel promises an opulent experience that couples will cherish.
What are the best spa hotels in Medical Center Area?
For those seeking a rejuvenating getaway, the Four Seasons Hotel One Dalton Street, Boston, stands out with a top rating of 9.6. This luxurious hotel features a full-service spa that offers a wide range of treatments, including couples treatment rooms, body wraps, and steam room facilities, ensuring a lavish and relaxing experience. Guests can indulge in soothing facials, massages, and body scrubs, making it a top choice for anyone looking to unwind in style.

Another excellent option is the Mandarin Oriental, Boston, also rated 9.4. This hotel offers an extensive spa menu, including hydrotherapy treatments and a hot tub for ultimate relaxation. Couples can enjoy a variety of massages, from Swedish to deep tissue, as well as special treatments designed just for them. The inclusive setting and attentive service make it an ideal spot for couples wanting to spend some quality time and indulge in some well-deserved pampering.

Both hotels provide a superb blend of luxury and thoughtful amenities, ensuring that your spa retreat is as enjoyable as it is restorative. Whether you're planning a romantic escape or simply wish to recharge, these exceptional options in the Medical Center Area cater to your every need, providing an unforgettable experience.
What hotels in Medical Center Area offer free breakfast?
The Residence Inn by Marriott Boston Downtown/South End is a fantastic choice for travelers seeking a vibrant stay in the Medical Center Area. This hotel not only offers free breakfast, featuring a delightful selection of continental options, but it also boasts spacious suites equipped with kitchenettes, making it great for families who appreciate the convenience of preparing meals. Guests rave about the 24-hour fitness facilities and the grocery shopping service, ensuring you can maintain your health routines while enjoying your trip.

For those wanting a cozy stay, the Hampton Inn & Suites Boston Crosstown Center is another worthy option. This property, also offering complimentary breakfast, features an inviting indoor pool where kids can splash around after a day of exploring. Families appreciate the accessible parking and the variety of amenities like self-parking and shopping on-site, enhancing the overall convenience of your stay.

Whether you're traveling with children or looking for a comfortable setting for a romantic getaway, these hotels provide the great blend of quality, convenience, and value in the bustling Medical Center Area.
What are the top boutique hotels in Medical Center Area?
The Eliot Hotel in Boston is a stunning boutique retreat that offers an exceptional blend of luxury and comfort, earning an impressive guest rating of 9.6. This exquisite property is renowned for its lavish amenities, including personalized champagne service that sets the tone for a romantic getaway. Couples will find delight in the elegantly appointed suites, adorned with premium bedding and designer toiletries, ensuring a restful stay filled with indulgence.

For those looking for a vibrant atmosphere, the Hotel Commonwealth is another stellar option, boasting a rating of 9.4. Nestled in a bustling shopping district, this hotel offers valet parking for convenience and plush bathrobes to enhance your experience. The ambience here is great for couples who appreciate modern elegance combined with easy access to local attractions.

Meanwhile, the Mandarin Oriental, Boston stands out with its 5-star rating of 9.4, featuring extraordinary amenities such as 24-hour room service and Frette Italian sheets that redefine comfort. This hotel's serene spa and exclusive dining options provide an intimate setting for couples looking to unwind and reconnect in style.

The Inn At St Botolph, rated 9.2, offers a cozy yet upscale atmosphere, ideal for couples seeking a more intimate experience. With premium bedding, air conditioning, and designer toiletries, this boutique hotel ensures a comfortable stay while being conveniently located near shopping districts.

Lastly, The Colonnade Hotel Back Bay, with a great rating of 9.0, is great for couples who enjoy a lively poolside bar scene alongside luxurious amenities such as Egyptian cotton sheets and plush bathrobes. This hotel embodies a chic and sophisticated environment, making it a delightful choice for those looking to indulge in boutique luxury.
What are the best budget hotels in Medical Center Area?
The Residence Inn by Marriott Boston Back Bay/Fenway stands out as a fantastic option for families seeking comfort and convenience. Guests rave about the hotel's spacious suites, complete with kitchenettes, which are great for preparing meals for little ones. The indoor pool offers a safe space for kids to splash around, while the complimentary breakfast ensures everyone starts their day off right. With a stellar review rating of 9.2, this hotel is popular for its family-friendly amenities, including free cribs and rollaway beds.

For those traveling with a larger family or looking for a more home-like setting, the Residence Inn by Marriott Boston Downtown/South End offers similar advantages. This property features premium suites with kitchens, enabling families to enjoy meals together in the comfort of their room. With an 8.8 rating from guests, it also provides a complimentary breakfast and easy access to the best of Boston's attractions, making it a practical choice for both families and couples seeking a cozy getaway.

If you're a couple looking for a romantic escape, consider the Newbury Guest House. This charming hotel, with a review score of 9.4, offers an intimate atmosphere with premium bedding and cozy fireplaces, great for a quiet retreat after a day of adventure. The location in the shopping district invites leisurely strolls and shopping experiences, making it a delightful option for couples looking to enjoy the vibrant city while still having a relaxing base.
What are the most romantic hotels in Medical Center Area for couples?
For a romantic escape in the Medical Center Area, The Eliot Hotel is a great choice, boasting a stellar rating of 9.6. This hotel offers a charming atmosphere complemented by thoughtful amenities, including couples dining experiences and pet-friendly options for those who wish to travel with their furry friends. With its historical district location, you can enjoy leisurely strolls with your partner while soaking in the local culture.

Another excellent option is Raffles Boston, also rated 9.6, where couples can indulge in a luxurious full-service spa featuring couples treatment rooms. The hotel's amenities, including an indoor pool and a hot tub, create a serene environment for relaxation and intimacy. Guests appreciate the attention to detail, from designer toiletries to 24-hour room service, ensuring that every aspect of your stay is enjoyable.

Iris Hotel Boston, rated 9.4, also offers a romantic setting with features like private indoor hot tubs and couples dining. Its cozy ambiance is superb for couples looking to unwind and reconnect after a day of exploring the city.

Each of these hotels provides a superb backdrop for couples seeking romance, comfort, and memorable experiences in the heart of the Medical Center Area. Whether it's enjoying a quiet moment together or indulging in spa treatments, you'll find a welcoming retreat that caters to your desires.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Medical Center Area hotel for you.
How can I save on a Medical Center Area hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Medical Center Area hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Medical Center Area hotel?
Hotel prices in Medical Center Area often vary, but you can find a great deal from $142 on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.