Title: Visit Melrose: 2026 Travel Guide for Melrose, Florida | Expedia.com [Hotels in Melrose](https://expedia.com/Melrose-Hotels.d3000431362.Travel-Guide-Hotels)[Vacation Rentals in Melrose](https://expedia.com/Melrose-Vacation-Rentals.d3000431362.Travel-Guide-VacationRentals)[Flights to Melrose](https://expedia.com/Cheap-Flights-To-Melrose.d3000431362.Travel-Guide-Flights)[Car Rentals in Melrose](https://expedia.com/Car-Rentals-In-Melrose.d3000431362.Car-Rental-Guide)[Melrose Vacation Packages](https://expedia.com/Melrose.d3000431362.Destination-Travel-Guides) # Melrose, FL ## Travel Guide ![Melrose](https://images.trvl-media.com/place/3000431362/0b90ed1d-67eb-4497-a9f6-f9ac696978e8.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Melrose Things to do - Melrose Hotel Deals - Vacation Rentals in Melrose ![3 Bedroom House on Private Scenic Lake Mable](https://images.trvl-media.com/lodging/94000000/93160000/93156100/93156079/w906h683x59y0-4020ce62_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 3 Bedroom House on Private Scenic Lake Mable Melrose FL Stay at this vacation home in Melrose. Enjoy free WiFi, a garden, and laundry facilities. Popular attraction Santa Fe Lake is located nearby. 9.8/10 Exceptional! (13 reviews) Amenities were fine. Reviewed on Feb 25, 2026 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F17%2F2026&endDate=4%2F18%2F2026&selected=93156079&PinnedHotelID=93156079&HadPinnedHotel=true®ionId=3000431362) [](https://expedia.com/Hotel-Search?startDate=4%2F17%2F2026&endDate=4%2F18%2F2026&selected=93156079&PinnedHotelID=93156079&HadPinnedHotel=true®ionId=3000431362) ![HOM Hotel Gainesville, SureStay Collection by Best Western](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/8a6fa57c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### HOM Hotel Gainesville, SureStay Collection by Best Western 3905 Sw 43Rd St Gainesville FL $77 nightly $87 total Apr 12 - Apr 13 Total with taxes and fees Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 8.4/10 Very Good! (1,864 reviews) Everything was great even the staff, room was very clean. 10/10 Reviewed on Apr 1, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=200755&PinnedHotelID=200755&HadPinnedHotel=true®ionId=3000431362) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/e387508a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Country Inn & Suites by Radisson, Gainesville, FL 4015 Sw 43rd St Gainesville FL $88 nightly $99 total Apr 13 - Apr 14 Total with taxes and fees Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.2/10 Wonderful! (1,740 reviews) We had a great overnight family of 4 stay. The breakfast buffet was surprisingly very good! The beds as well as the pillows were very comfortable. The only negative was the bathroom sink drained a little slow so I only gave it four stars under the cleanliness rating. Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F13%2F2026&endDate=4%2F14%2F2026&selected=1289043&PinnedHotelID=1289043&HadPinnedHotel=true®ionId=3000431362) [See all 868 properties in Melrose](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F4%2F2026&endDate=4%2F5%2F2026®ionId=3000431362) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![House in Melrose on Lake Sante Fe](https://images.trvl-media.com/lodging/101000000/100030000/100023700/100023634/e28101ba_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### House in Melrose on Lake Sante Fe Melrose FL Stay at this vacation home in Melrose. Enjoy a garden, laundry facilities, and patios. Popular attraction Santa Fe Lake is located nearby. 10/10 Exceptional! (13 reviews) Beautiful quiet property on the lake and great for families. Reviewed on Mar 10, 2026 [](https://expedia.com/Melrose-Hotels-House-In-Melrose-On-Lake-Sante-Fe.h100023634.Hotel-Information) ![Rustic Fishing Cabin on Lake Swan, Melrose](https://images.trvl-media.com/lodging/77000000/76550000/76548500/76548421/53f94235_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rustic Fishing Cabin on Lake Swan, Melrose Melrose FL Stay at this cabin in Melrose. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker. Popular attraction Santa Fe Lake is located nearby. 10/10 Exceptional! (29 reviews) The pictures don’t do this place justice, it’s beautiful and the beds slept perfect, we will be back Reviewed on Apr 2, 2026 [](https://expedia.com/Melrose-Hotels-Rustic-Fishing-Cabin-On-Lake-Swan.h76548421.Hotel-Information) ![3 Bedroom House on Private Scenic Lake Mable](https://images.trvl-media.com/lodging/94000000/93160000/93156100/93156079/w906h683x59y0-4020ce62_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 3 Bedroom House on Private Scenic Lake Mable Melrose FL Stay at this vacation home in Melrose. Enjoy free WiFi, a garden, and laundry facilities. Popular attraction Santa Fe Lake is located nearby. 9.8/10 Exceptional! (13 reviews) Amenities were fine. Reviewed on Feb 25, 2026 [](https://expedia.com/Melrose-Hotels-3-Bedroom-House-On-Private-Scenic-Lake-Mable.h93156079.Hotel-Information) [See all properties in Melrose](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000431362&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Melrose hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=2026-04-03&endDate=2026-04-04)[Apr 3 - Apr 4](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=2026-04-03&endDate=2026-04-04) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=2026-04-04&endDate=2026-04-05)[Apr 4 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=2026-04-04&endDate=2026-04-05) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000431362&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026) ### Popular places to visit #### Single Vision Inc. See the exotic and native animals who call Single Vision Inc. home during your trip to Melrose. While you're in the area, wander around the parks. [](https://expedia.com/Single-Vision-Inc-Melrose.d553248621532654075.Vacation-Attraction) ## Cities near Melrose ![Little Devil's Spring on the Santa Fe River, Gilchrist County, Florida](https://images.trvl-media.com/place/7113/c94b2830-c3dc-4b8e-85ae-2ef81bf5b73f.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Starke ![Early Winter Morning at Ginnie Springs on the Santa Fe River, Florida ](https://images.trvl-media.com/place/6094592/37b6770f-7d44-4947-893a-9c78f4da8098.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Waldo ![Aerial View of Florida Lakes](https://images.trvl-media.com/place/6351663/3b2bf0e0-b7c8-4f5f-a972-a77a1a6bdb0c.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Keystone Heights ![Interlachen](https://images.trvl-media.com/place/6355346/421736d5-6ed7-4872-9786-4ded67f1dafb.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Interlachen ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Earleton Hotels ](https://www.expedia.com/Earleton-Hotels.d3000345210.Travel-Guide-Hotels) - 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[Hotels near Gold Head Branch State Park ](https://www.expedia.com/Gold-Head-Branch-State-Park-Hotels.0-l6184480-0.Travel-Guide-Filter-Hotels) - [Interlachen Hotels ](https://www.expedia.com/Interlachen-Hotels.d6355346.Travel-Guide-Hotels) - [Cabin Rentals in Interlachen ](https://www.expedia.com/Interlachen-Cabins.d6355346-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Interlachen ](https://www.expedia.com/Interlachen-RV-Parks.d6355346-aaRVParks.Travel-Guide-Accommodation) - [B&B in Interlachen ](https://www.expedia.com/Interlachen-Bed-And-Breakfast.d6355346-aaBedAndBreakfast.Travel-Guide-Accommodation) - [3 Star Hotels in Interlachen ](https://www.expedia.com/3Star-Interlachen-Hotels.s30-0-d6355346.Travel-Guide-Filter-Hotels) - [Motels in Interlachen ](https://www.expedia.com/Interlachen-Motels.d6355346-aaMotels.Travel-Guide-Accommodation) - [Vacation Homes in Interlachen ](https://www.expedia.com/Interlachen-Private-Vacation-Homes.d6355346-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Lodges in Interlachen ](https://www.expedia.com/Interlachen-Lodges.d6355346-aaLodges.Travel-Guide-Accommodation) - [Hampton Hotels ](https://www.expedia.com/Hampton-Hotels.d553248634998679281.Travel-Guide-Hotels) - [Gainesville Hotels ](https://www.expedia.com/Gainesville-Hotels.d6048189.Travel-Guide-Hotels) - [Flights to Keystone Heights ](https://www.expedia.com/Cheap-Flights-To-Keystone-Heights.d6351663.Travel-Guide-Flights) - [Flights from Keystone Heights ](https://www.expedia.com/lp/flights/6351663/flights-from-keystone-heights) - [Flights to Hawthorne ](https://www.expedia.com/Cheap-Flights-To-Hawthorne.d6351661.Travel-Guide-Flights) - [Flights from Gainesville Regional ](https://www.expedia.com/lp/airports/gnv/flights-from-gainesville-regional-airport) - [Flights to Waldo ](https://www.expedia.com/Cheap-Flights-To-Waldo.d6094592.Travel-Guide-Flights) - [Flights from Waldo ](https://www.expedia.com/lp/flights/6094592/flights-from-waldo) - [Flights from Florahome ](https://www.expedia.com/lp/flights/3000345223/flights-from-florahome) - [Flights to Interlachen ](https://www.expedia.com/Cheap-Flights-To-Interlachen.d6355346.Travel-Guide-Flights) - [Flights from Interlachen ](https://www.expedia.com/lp/flights/6355346/flights-from-interlachen) - [Flights from Fort Lauderdale (FLL) to Gainesville (GNV) ](https://www.expedia.com/lp/flights/fll/gnv/fort-lauderdale-to-gainesville) - [Visit Earleton ](https://www.expedia.com/Earleton.dx3000345210) - [Visit Keystone Heights ](https://www.expedia.com/Keystone-Heights.dx6351663) - [Keystone Heights Vacations ](https://www.expedia.com/Keystone-Heights.d6351663.Destination-Travel-Guides) - [Visit Hawthorne ](https://www.expedia.com/Hawthorne.dx6351661) - [Hawthorne Vacations ](https://www.expedia.com/Hawthorne.d6351661.Destination-Travel-Guides) - [Visit Waldo ](https://www.expedia.com/Waldo.dx6094592) - [Waldo Vacations ](https://www.expedia.com/Waldo.d6094592.Destination-Travel-Guides) - [Visit Florahome ](https://www.expedia.com/Florahome.dx3000345223) - [Waldo Motorsports ](https://www.expedia.com/Waldo-Motorsports-Waldo.d6128078.Vacation-Attraction) - [Visit Interlachen ](https://www.expedia.com/Interlachen.dx6355346) - [Gold Head Branch State Park ](https://www.expedia.com/Gold-Head-Branch-State-Park-Keystone-Heights.d6184480.Vacation-Attraction) - [Interlachen Vacations ](https://www.expedia.com/Interlachen.d6355346.Destination-Travel-Guides) - [Car rentals near Keystone Heights ](https://www.expedia.com/Car-Rentals-In-Keystone-Heights.d6351663.Car-Rental-Guide) - [Hertz Rental Cars in Keystone Heights ](https://www.expedia.com/Hertz-Car-Rentals-In-Keystone-Heights.d6351663-c40.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Keystone Heights ](https://www.expedia.com/Avis-Car-Rentals-In-Keystone-Heights.d6351663-c41.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in Keystone Heights ](https://www.expedia.com/Enterprise-Car-Rentals-In-Keystone-Heights.d6351663-c15.Car-Rental-Guide-Suppliers) - [Car rentals near Orange Heights ](https://www.expedia.com/Car-Rentals-In-Orange-Heights.d553248635974906363.Car-Rental-Guide) - [Car rentals near Grandin ](https://www.expedia.com/Car-Rentals-In-Grandin.d553248635975871409.Car-Rental-Guide) - [Car rentals near Hawthorne ](https://www.expedia.com/Car-Rentals-In-Hawthorne.d6351661.Car-Rental-Guide) - [Enterprise Rental Cars in Hawthorne ](https://www.expedia.com/Enterprise-Car-Rentals-In-Hawthorne.d6351661-c15.Car-Rental-Guide-Suppliers) - [Car rentals near Waldo ](https://www.expedia.com/Car-Rentals-In-Waldo.d6094592.Car-Rental-Guide) - [Enterprise Rental Cars in Waldo ](https://www.expedia.com/Enterprise-Car-Rentals-In-Waldo.d6094592-c15.Car-Rental-Guide-Suppliers) - [Hiper Rent a Car Rental Cars in Waldo ](https://www.expedia.com/Hiper-Rent-A-Car-Car-Rentals-In-Waldo.d6094592-c1026.Car-Rental-Guide-Suppliers) - [Car rentals near Windsor ](https://www.expedia.com/Car-Rentals-In-Windsor.d553248635975850362.Car-Rental-Guide) - [Car rentals near Florahome ](https://www.expedia.com/Car-Rentals-In-Florahome.d3000345223.Car-Rental-Guide) - [Car rentals near Waldo Motorsports ](https://www.expedia.com/Car-Rentals-In-Waldo-Motorsports.d6128078.Car-Rental-Guide) - [Car rentals near Interlachen ](https://www.expedia.com/Car-Rentals-In-Interlachen.d6355346.Car-Rental-Guide) - 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[University of Florida ](https://expedia.com/University-Of-Florida-Gainesville.d6068631.Vacation-Attraction) - [Ben Hill Griffin Stadium ](https://expedia.com/Ben-Hill-Griffin-Stadium-Gainesville.d6068633.Vacation-Attraction) - [Shands at the University of Florida ](https://expedia.com/Shands-At-The-University-Of-Florida-Gainesville.d6187967.Vacation-Attraction) - [Ocala National Forest ](https://expedia.com/Ocala-National-Forest-Florida.d6091129.Vacation-Attraction) - [Gainesville Raceway ](https://expedia.com/Gainesville-Raceway-Gainesville.d6128074.Vacation-Attraction) - [Paynes Prairie Preserve State Park ](https://expedia.com/Paynes-Prairie-Preserve-State-Park-Florida.d6068627.Vacation-Attraction) - [North Florida Regional Medical Center ](https://expedia.com/North-Florida-Regional-Medical-Center-Gainesville.d6187962.Vacation-Attraction) - [Oaks Mall ](https://expedia.com/Oaks-Mall-Gainesville.d6128062.Vacation-Attraction) - [Santa Fe River ](https://expedia.com/Santa-Fe-River-Florida.d684510373599707136.Vacation-Attraction) - 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