Find hotels in Melrose, FL from $54

These Melrose insights are based on real traveler data from Expedia, aggregated using AI to help you plan your trip. Updated: August 21, 2026.

Top reasons to visit Melrose

• Outdoor Adventures: Melrose is ideal for exploring beautiful lakes, national and state parks, and urban parks, perfect for nature enthusiasts.
• Charming Atmosphere: The friendly vibe and inviting main streets make Melrose a great destination for romantic getaways or family fun.
• Unique Experiences: Don't miss whale watching, which offers a memorable touch to your vacation in this quaint town.
• Variety of Accommodations: Choose from cozy motels to inviting hotels, catering to diverse vacation needs.
• Accessible Location: Just a short drive from Gainesville and Palatka, Melrose is conveniently located for easy exploration.

Find great hotels near Melrose

Discover a range of hotel accommodations in Melrose, Florida, perfect for your vacation needs. Whether you're seeking a pet-friendly stay, a comfortable spot for business travel, or an adventure-filled experience, Melrose offers a variety of options. From cozy motels to inviting hotels, you'll find the perfect room to make your visit enjoyable and memorable.

• Hotel Eleo at the University of Florida: A 3.5-star hotel with an impressive guest rating of 9.4, Hotel Eleo at the University of Florida is a charming retreat located 18 miles from Melrose. This property stands out for its pet-friendly atmosphere, making it an excellent choice for travelers who wish to bring their furry companions along. With a variety of pet amenities, including a fee-waived service animal policy, guests can feel at home while enjoying the university's vibrant surroundings. The hotel offers a stylish blend of modern comfort and Southern hospitality, creating an inviting space for both relaxation and exploration.
• Hyatt Place Gainesville Downtown: A 3-star hotel with a notable guest rating of 9.2, Hyatt Place Gainesville Downtown is situated 17 miles from Melrose and caters to families and business travelers alike. This property features a unique hot spring theme, with nearby access to natural hot springs for a rejuvenating experience. Amenities for children, such as free cribs and pool toys, ensure that families can enjoy their stay without compromising comfort. The hotel's modern design and welcoming atmosphere make it an ideal base for exploring the vibrant downtown area while enjoying quality time with loved ones.
• Hampton Inn & Suites Gainesville-Downtown: A budget-friendly option with a guest rating of 8.6, Hampton Inn & Suites Gainesville-Downtown is located 17 miles from Melrose. This hotel is perfect for travelers seeking a pet-friendly environment while balancing business and leisure. It has a pet policy that accommodates various sizes, with fees waived for service animals. Guests will appreciate the comfortable rooms, complimentary breakfast, and convenient access to downtown, making it a practical choice for those looking to stay connected while enjoying the local attractions.

Where to stay in and around Melrose

Melrose, Florida, offers a charming escape with its friendly atmosphere and outdoor allure, perfect for romantic getaways or family adventures. Just a short drive from nearby cities like Gainesville and Palatka, you'll find local amenities and inviting main streets to explore. Enjoy scenic views and summer staycations that highlight the beauty of this hidden gem, making it an ideal destination for relaxation and discovery.

• Earleton: Nestled just 3 miles from Melrose, Earleton is a charming city that offers a delightful outdoor experience, making it a popular choice for those seeking scenic views and romantic getaways. Visitors can explore its beautiful recreational areas, indulge in adventure activities, and even dive into underwater sports. The proximity to stunning lakes, rivers, and a national state park enhances its appeal, providing ample opportunities for nature lovers to immerse themselves in the great outdoors. The best time to visit is during the peak months of March, August, and November, when the weather is ideal for outdoor adventures.
• Grandin: Located close to Melrose, Grandin is a quaint village known for its picturesque scenery and romantic atmosphere. Travelers flock here for its serene charm, with the local lakes serving as perfect spots for relaxation and reflection. The village provides a peaceful escape from the hustle and bustle, making it an ideal destination for couples and outdoor enthusiasts alike. Similar to Earleton, Grandin experiences peak visitor numbers in March, August, and November, making these months perfect for a visit to enjoy its natural beauty.
• Keystone Heights: A mere 5 miles from Melrose, Keystone Heights is a unique city characterized by its island-like features. This vibrant locale is a haven for outdoor enthusiasts, offering various recreational areas and adventure activities, including underwater sports. Visitors are drawn to its breathtaking lakes, rivers, and the nearby national state park, which provide stunning backdrops for exploration and relaxation. Keystone Heights sees peak travel seasons in February to March and December, making it an excellent choice for tourists looking to connect with nature and enjoy a romantic getaway.

Things to do near Melrose

Melrose, Florida, is perfect for outdoor adventures and romantic getaways. Visitors can enjoy a range of activities, including exploring the beautiful recreational areas, indulging in educational experiences, and hitting the golf courses. While shopping opportunities abound, don't miss the chance for unique experiences like whale watching, which adds a memorable touch to your vacation in this charming town.

Shopping

In Melrose, enjoy local shops offering unique gifts and souvenirs. If you're up for a drive, visit the Gainesville Mall, about 15 miles away, which features a variety of national retailers and dining options for a more extensive shopping experience.

Recreation

Haile Plantation Golf and Country Club offers a luxurious golfing experience just 25 miles from Melrose, featuring pristine greens and upscale amenities. Similarly, Magnolia Point Golf and Country Club, located 29 miles away, provides an elegant atmosphere perfect for relaxation and recreation amidst beautiful landscapes.

Adventure

Explore the serene waters of Lake Santa Fe for kayaking and fishing, or hike the scenic trails at the nearby San Felasco Hammock Preserve State Park for a chance to spot local wildlife. For a thrilling experience, try horseback riding at local stables for a fun adventure.

Nightlife

Explore the vibrant nightlife in Melrose by visiting The Melrose Community Center for local events and gatherings. For a laid-back evening, check out the Melrose Pub, where you can enjoy a cold drink and mingle with friendly locals in a cozy atmosphere.

Booking tips and Expedia advantages for Melrose

• The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Melrose are July and December to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
• The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Melrose is Tuesday. The most expensive day to stay in Melrose is Saturday.
• Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your travel preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly hotels currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
• Consider bundling your trip: You can save money by combining your hotel stay in Melrose with your flights and activities through an Expedia package deal.

Find the best attractions near Melrose

Melrose, Florida, is perfect for outdoor enthusiasts and romantic getaways, offering stunning scenery and a variety of attractions. Visitors can explore beautiful lakes, venture into nearby national and state parks, or relax in urban parks. For those seeking a beach experience or vibrant outdoor activities, Melrose provides a delightful escape into nature, making it an ideal destination for travelers looking to enjoy the great outdoors.

• Santa Fe Lake: Located 3 miles from Melrose, Santa Fe Lake offers a serene escape with its picturesque scenery and sandy beach vibes. It's perfect for a romantic day or a family outing, providing opportunities for swimming, picnicking, and enjoying nature's beauty.
• Gold Head Branch State Park: Situated 11 miles away, this state park is a haven for adventure lovers. Explore its scenic trails, discover diverse wildlife, and enjoy outdoor activities like hiking, biking, and camping amidst lush landscapes.
• Lake Como United Methodist Church: About 15 miles from Melrose, this church invites visitors to experience its rich cultural heritage. Attend a service or enjoy the community events that highlight the local traditions and values.

Best time to go to Melrose

The best time to visit Melrose is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are average and weather is mostly sunny. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

Calendar Month	Temperature	Precipitation	Cloudiness	Occupancy	Pricing
January	55.8°F (13.2°C)	Light Rain	Mostly Sunny	Average	Slightly Low
February	60.1°F (15.6°C)	Light Rain	Mostly Sunny	Average	Average
March	64.2°F (17.9°C)	Light Rain	Mostly Sunny	Average	Average
April	70.2°F (21.2°C)	Light Rain	Mostly Sunny	Slightly High	Average
May	75.6°F (24.2°C)	Light Rain	Mostly Sunny	Average	Slightly High
June	80.1°F (26.7°C)	Light Rain	Mostly Sunny	Average	Average
July	81.5°F (27.5°C)	Light Rain	Mostly Sunny	Slightly High	Slightly Low
August	81.5°F (27.5°C)	Light Rain	Mostly Sunny	Average	Average
September	78.6°F (25.9°C)	Light Rain	Mostly Sunny	Slightly High	Slightly High
October	72.0°F (22.2°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly High
November	63.9°F (17.7°C)	Light Rain	Mostly Sunny	Slightly Low	Average
December	59.9°F (15.5°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly Low

The nearest major airports for your trip to Melrose

Traveling to Melrose, Florida, is convenient with three major airports nearby. Jacksonville International Airport (JAX) is 58 miles away, with hotels like the DoubleTree by Hilton Hotel Jacksonville Airport, just 0.3 miles from the airport, and the Hyatt Regency Jacksonville, located 12 miles away. Daytona Beach International Airport (DAB), situated 70 miles from Melrose, offers nearby accommodations such as The Shores Resort & Spa and Daytona Grande Oceanfront Resort, both 4 miles away. Gainesville Regional Airport (GNV) is the closest at 14 miles, featuring hotels like DoubleTree by Hilton Gainesville, 8 miles away, and Hotel Eleo at the University of Florida, just 5 miles from the airport.