$119 Cheap Flights from Des Moines (DSM) to Greenville (GSP)

View $119 flight on Wed, Dec 24, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)

Cheap Flights from Des Moines to Greenville (DSM-GSP)

Prices were available within the past 7 days and start at $119 for one-way flights and $237 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Sep 22 - Mon, Oct 6
DSM
Des Moines
GSP
Greenville
$237 Roundtrip, found 1 hour ago
$237
Roundtrip
found 1 hour ago
Select Delta flight, departing Mon, Sep 22 from Des Moines to Greenville, returning Mon, Oct 6, priced at $237 found 1 hour ago
United
Wed, Aug 20 - Mon, Aug 25
DSM
Des Moines
GSP
Greenville
$237 Roundtrip, found 3 days ago
$237
Roundtrip
found 3 days ago
Select United flight, departing Wed, Aug 20 from Des Moines to Greenville, returning Mon, Aug 25, priced at $237 found 3 days ago
American Airlines
Sat, Oct 4 - Wed, Oct 8
DSM
Des Moines
GSP
Greenville
$239 Roundtrip, found 1 day ago
$239
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 4 from Des Moines to Greenville, returning Wed, Oct 8, priced at $239 found 1 day ago
Southwest Airlines
Wed, Aug 20 - Mon, Aug 25
DSM
Des Moines
GSP
Greenville
$242 Roundtrip, found 3 days ago
$242
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Aug 20 from Des Moines to Greenville, returning Mon, Aug 25, priced at $242 found 3 days ago
American Airlines
Mon, Sep 29 - Fri, Oct 3
DSM
Des Moines
GSP
Greenville
$244 Roundtrip, found 2 hours ago
$244
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Mon, Sep 29 from Des Moines to Greenville, returning Fri, Oct 3, priced at $244 found 2 hours ago
American Airlines
Wed, Oct 15 - Sun, Oct 19
DSM
Des Moines
GSP
Greenville
$246 Roundtrip, found 20 hours ago
$246
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Wed, Oct 15 from Des Moines to Greenville, returning Sun, Oct 19, priced at $246 found 20 hours ago
Southwest Airlines
Wed, Sep 10 - Sat, Sep 13
DSM
Des Moines
GSP
Greenville
$247 Roundtrip, found 2 days ago
$247
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Sep 10 from Des Moines to Greenville, returning Sat, Sep 13, priced at $247 found 2 days ago
Delta
Fri, Sep 26 - Fri, Oct 3
DSM
Des Moines
GSP
Greenville
$251 Roundtrip, found 1 hour ago
$251
Roundtrip
found 1 hour ago
Select Delta flight, departing Fri, Sep 26 from Des Moines to Greenville, returning Fri, Oct 3, priced at $251 found 1 hour ago
United
Tue, Aug 26 - Thu, Aug 28
DSM
Des Moines
GSP
Greenville
$252 Roundtrip, found 6 days ago
$252
Roundtrip
found 6 days ago
Select United flight, departing Tue, Aug 26 from Des Moines to Greenville, returning Thu, Aug 28, priced at $252 found 6 days ago
American Airlines
Sun, Sep 7 - Sun, Sep 14
DSM
Des Moines
GSP
Greenville
$255 Roundtrip, found 10 hours ago
$255
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sun, Sep 7 from Des Moines to Greenville, returning Sun, Sep 14, priced at $255 found 10 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Greenville (GSP)

August is typically the cheapest month to fly

From $174 - $616 per traveler.

Graph displaying average flight prices per month

Alternative airports near Greenville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Greenville-Spartanburg Intl. GSP. Cheapest option available. Average driving time to city center is 18 minutes. Flights from $427
GSP
Greenville-Spartanburg Intl.
Cheapest
Average driving time to city center18 min
Flights from $427
Flights from Des Moines (DSM) to Greenville (GSP)
Origin airport
Des Moines Intl.
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$236
Distance
770 mi

Des Moines to Greenville Flights

The cheapest times to fly from Des Moines to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Greenville are during the month of September. You can find some of the cheapest flights from Des Moines to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Greenville

Sunday is one of the best days to book for cheap flights from Des Moines to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $119 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Discover the latest flight deals from DSM to GSP by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to GSP?
The cheapest flights from DSM to GSP are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to GSP?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to GSP. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
There are no daily nonstop flights from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from DSM to GSP?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
To arrive at Greenville-Spartanburg Intl. Airport (GSP) without delays, choose a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Last-minute bookings from DSM to GSP are typically more expensive. To lock in the lowest prices, start searching for flights well in advance. That being said, if you're flexible with your travel dates, you may score a cheap ticket right before you leave.
Is it cheaper to book a DSM to GSP flight and hotel package?
You'll typically save money by securing a DSM to GSP flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your preferred accommodations and flights, you can add extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Greenville-Spartanburg Intl. Airport (GSP)?
Typically, you can cancel or modify your DSM to GSP flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you want further details, visit our Customer Service portal.

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*Available to One Key members.