$550 Cheap Flights from Myrtle Beach (MYR) to Santiago (SCL)

View $550 flight on Tue, Nov 4, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Santiago Intl. Airport (SCL)

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Cheap Flights from Myrtle Beach to Santiago (MYR-SCL)

Prices were available within the past 7 days and start at $550 for one-way flights and $818 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$818 Roundtrip, found 5 days ago
$818
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $818 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$825 Roundtrip, found 5 days ago
$825
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $825 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$834 Roundtrip, found 5 days ago
$834
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $834 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$838 Roundtrip, found 5 days ago
$838
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $838 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$841 Roundtrip, found 5 days ago
$841
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $841 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$845 Roundtrip, found 5 days ago
$845
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $845 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$847 Roundtrip, found 5 days ago
$847
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $847 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$850 Roundtrip, found 5 days ago
$850
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $850 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$852 Roundtrip, found 5 days ago
$852
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $852 found 5 days ago
LATAM Airlines Group
Tue, Nov 4 - Wed, Nov 12
MYR
Myrtle Beach
SCL
Santiago
$853 Roundtrip, found 5 days ago
$853
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Nov 4 from Myrtle Beach to Santiago, returning Wed, Nov 12, priced at $853 found 5 days ago
Flights from Myrtle Beach (MYR) to Santiago (SCL)
Origin airport
Myrtle Beach Intl.
Destination airport
Arturo Merino Benitez
Roundtrip price
$817
Distance
4664 mi

Myrtle Beach to Santiago Flights

The cheapest times to fly from Myrtle Beach to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santiago are during the month of November. You can find some of the cheapest flights from Myrtle Beach to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santiago

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $550 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from MYR to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MYR to SCL?
The cheapest flights from MYR to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MYR to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MYR to SCL. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to SCL?
Generally you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
To touch down at Arturo Merino Benitez Airport (SCL) without delays, select a flight that takes off from Myrtle Beach Intl. Airport (MYR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL) last-minute?
Holding off until just before your departure to book a flight from MYR to SCL often results in higher prices. While you may find some last-minute discounts, they aren't always guaranteed. Allow some flexibility in your schedule for a better chance of scoring a bargain.
Is it cheaper to book a MYR to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a MYR to SCL flight and hotel package with Expedia could result in significant savings. What's more, having it all in one place will take the hassle out of planning your trip. Just pick your flights and select from our wide range of stays, then customize your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Arturo Merino Benitez Airport (SCL)?
If you booked your MYR to SCL flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.