Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
$50
per adult
92% of travellers recommend
Key West Sunset Sail with Live Music, Drinks and Appetizers!
$80
per adult
92% of travellers recommend
Day trip to Paradise from Miami: Key West Tour with Snorkeling, Open bar
$27
per adult
80% of travellers recommend
Miami to Key West Day Trip with Activity Options
$39
per adult
82% of travellers recommend
Lands End Sunset Cruise with Full Bar & Live Music
$75
per adult
90% of travellers recommend
Key West Afternoon At The Reef Snorkeling Adventure with Open Bar!
$53
per adult
90% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL
$228 nightly
The price is $257 total per night from Oct 28 to Oct 29
$257 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,775 reviews)
"We loved thi"
Reviewed on Oct 7, 2025
Southwinds Motel
1321 Simonton Street, Key West, FL
$146 nightly
The price is $165 total per night from Oct 13 to Oct 14
$165 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,191 reviews)
"Super fun! Pool was great because it was hot. Onsite bar was very fun!!"
Reviewed on Oct 5, 2025
The Southernmost Inn - Adults Only
525 United Street, Key West, FL
$139 nightly
The price is $156 total per night from Oct 13 to Oct 14
$156 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,163 reviews)
"Great area, amenities are great"
Reviewed on Sep 28, 2025
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL
$258 nightly
The price is $290 total per night from Oct 27 to Oct 28
$290 total
Oct 27 - Oct 28
Total with taxes and fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,002 reviews)
"The receptionists were very friendly and helpful and 4 Marlins was food exquisite !"
Reviewed on Oct 3, 2025
Santa Maria Suites
1401 Simonton St, Key West, FL
$318 nightly
The price is $358 total per night from Oct 13 to Oct 14
$358 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this 4-star resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,000 reviews)
"Lovely property! Lovely stay. Surprised to see ashtrays on balconies and I could not use my balcony without both neighbors smoking, haven’t seen this in years."
Reviewed on Oct 3, 2025
Kona Kai Oasis
630 South Street, Key West, FL
$125 nightly
The price is $141 total per night from Oct 13 to Oct 14
$141 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this 3-star guesthouse in Key West. Enjoy free WiFi, free parking, and a garden. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (560 reviews)
"Yes plenty of shops near by and not sure about pets"
Reviewed on Sep 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(226 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Bahama Village
5/5(38 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Key West AIDS Memorial.
Key West Historic District
4.5/5(4,033 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Saint Mary Star of the Sea, some noteworthy sights in the nearby area.
Uptown - Upper Duval, FL
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