$1,019 Cheap Flights from Denver (DEN) to São Tomé Island (TMS)

View $1,019 flight on Thu, Nov 13, 2025Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to São Tomé Island (TMS-São Tomé Intl.)

Cheap Flights from Denver to São Tomé Island (DEN-TMS)

Prices were available within the past 7 days and start at $1,019 for one-way flights and $1,460 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Sat, Sep 20 - Sun, Sep 28
DEN
Denver
TMS
São Tomé Island
$1,460 Roundtrip, found 1 day ago
$1,460
Roundtrip
found 1 day ago
Select United flight, departing Sat, Sep 20 from Denver to São Tomé Island, returning Sun, Sep 28, priced at $1,460 found 1 day ago
United
Fri, Sep 19 - Sun, Sep 28
DEN
Denver
TMS
São Tomé Island
$1,470 Roundtrip, found 1 day ago
$1,470
Roundtrip
found 1 day ago
Select United flight, departing Fri, Sep 19 from Denver to São Tomé Island, returning Sun, Sep 28, priced at $1,470 found 1 day ago
United
Tue, Sep 23 - Sun, Sep 28
DEN
Denver
TMS
São Tomé Island
$1,523 Roundtrip, found 1 day ago
$1,523
Roundtrip
found 1 day ago
Select United flight, departing Tue, Sep 23 from Denver to São Tomé Island, returning Sun, Sep 28, priced at $1,523 found 1 day ago
Swiss International Air Lines
Mon, Sep 22 - Sun, Sep 28
DEN
Denver
TMS
São Tomé Island
$1,538 Roundtrip, found 1 day ago
$1,538
Roundtrip
found 1 day ago
Select Swiss International Air Lines flight, departing Mon, Sep 22 from Denver to São Tomé Island, returning Sun, Sep 28, priced at $1,538 found 1 day ago
United
Sat, Sep 20 - Fri, Sep 26
DEN
Denver
TMS
São Tomé Island
$1,563 Roundtrip, found 1 day ago
$1,563
Roundtrip
found 1 day ago
Select United flight, departing Sat, Sep 20 from Denver to São Tomé Island, returning Fri, Sep 26, priced at $1,563 found 1 day ago
United
Fri, Sep 19 - Fri, Sep 26
DEN
Denver
TMS
São Tomé Island
$1,573 Roundtrip, found 1 day ago
$1,573
Roundtrip
found 1 day ago
Select United flight, departing Fri, Sep 19 from Denver to São Tomé Island, returning Fri, Sep 26, priced at $1,573 found 1 day ago
United
Tue, Sep 23 - Fri, Sep 26
DEN
Denver
TMS
São Tomé Island
$1,626 Roundtrip, found 1 day ago
$1,626
Roundtrip
found 1 day ago
Select United flight, departing Tue, Sep 23 from Denver to São Tomé Island, returning Fri, Sep 26, priced at $1,626 found 1 day ago
Swiss International Air Lines
Mon, Sep 22 - Fri, Sep 26
DEN
Denver
TMS
São Tomé Island
$1,641 Roundtrip, found 1 day ago
$1,641
Roundtrip
found 1 day ago
Select Swiss International Air Lines flight, departing Mon, Sep 22 from Denver to São Tomé Island, returning Fri, Sep 26, priced at $1,641 found 1 day ago
Lufthansa
Sun, Mar 15 - Sun, Mar 22
DEN
Denver
TMS
São Tomé Island
$1,704 Roundtrip, found 1 day ago
$1,704
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Sun, Mar 15 from Denver to São Tomé Island, returning Sun, Mar 22, priced at $1,704 found 1 day ago
Lufthansa
Sun, Mar 15 - Sun, Mar 22
DEN
Denver
TMS
São Tomé Island
$1,705 Roundtrip, found 1 day ago
$1,705
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Sun, Mar 15 from Denver to São Tomé Island, returning Sun, Mar 22, priced at $1,705 found 1 day ago

Alternative airports near São Tomé

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Sao Tome Intl. TMS. Cheapest option available. Flights from $1,523
TMS
Sao Tome Intl.
Cheapest
Flights from $1,523
Flights from Denver (DEN) to São Tomé Island (TMS)
Origin airport
Denver Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$1,459
Distance
7324 mi

Denver to São Tomé Island Flights

The cheapest times to fly from Denver to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to São Tomé Island are during the month of September. You can find some of the cheapest flights from Denver to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to São Tomé Island

Sunday is one of the best days to book for cheap flights from Denver to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,019 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) cost?
Snag a cheap one-way flight from $1,019 or cheap return flight from $1,460 from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
September is the least expensive month to fly from DEN to TMS. Traveling outside of peak seasons is often the key to scoring lower fares.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DEN to TMS flight.
How many flights per day from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
You'll need to book a flight with a layover if you're traveling from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from DEN to TMS?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
To land at Sao Tome Intl. Airport (TMS) on time, opt for a flight that leaves Denver Intl. Airport (DEN) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS) last-minute?
Last-minute fares from DEN to TMS are generally more expensive. For the lowest prices, start searching for flights well ahead of time. That said, if you can play around with your travel dates, you may land a cheap fare just before your departure.
Is it cheaper to book a DEN to TMS flight and hotel package?
Compared with arranging flights and hotels separately, booking a DEN to TMS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of stays, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to Sao Tome Intl. Airport (TMS)?
It's generally possible to cancel or reschedule your DEN to TMS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.