$121 Cheap Flights from Panama City (PTY) to Medellín (MDE)

View $121 flight on Wed, Nov 12, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)

Cheap Flights from Panama City to Medellín (PTY-MDE)

Prices were available within the past 7 days and start at $121 for one-way flights and $224 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Nov 12 - Wed, Nov 19
PTY
Panama City
MDE
Medellin
$224 Roundtrip, just found
$224
Roundtrip
just found
Select Copa flight, departing Wed, Nov 12 from Panama City to Medellin, returning Wed, Nov 19, priced at $224 just found
Copa
Wed, Nov 12 - Wed, Nov 19
PTY
Panama City
MDE
Medellin
$234 Roundtrip, just found
$234
Roundtrip
just found
Select Copa flight, departing Wed, Nov 12 from Panama City to Medellin, returning Wed, Nov 19, priced at $234 just found
Copa
Sat, Nov 15 - Mon, Nov 17
PTY
Panama City
MDE
Medellin
$245 Roundtrip, found 4 hours ago
$245
Roundtrip
found 4 hours ago
Select Copa flight, departing Sat, Nov 15 from Panama City to Medellin, returning Mon, Nov 17, priced at $245 found 4 hours ago
Copa
Fri, Jan 9 - Fri, Jan 16
PTY
Panama City
MDE
Medellin
$255 Roundtrip, found 11 hours ago
$255
Roundtrip
found 11 hours ago
Select Copa flight, departing Fri, Jan 9 from Panama City to Medellin, returning Fri, Jan 16, priced at $255 found 11 hours ago
Copa
Fri, Dec 12 - Mon, Dec 15
PTY
Panama City
MDE
Medellin
$266 Roundtrip, found 1 day ago
$266
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Dec 12 from Panama City to Medellin, returning Mon, Dec 15, priced at $266 found 1 day ago
avianca
Fri, Nov 14 - Mon, Nov 17
PTY
Panama City
MDE
Medellin
$266 Roundtrip, just found
$266
Roundtrip
just found
Select avianca flight, departing Fri, Nov 14 from Panama City to Medellin, returning Mon, Nov 17, priced at $266 just found
Copa
Wed, Nov 12 - Wed, Nov 19
PTY
Panama City
MDE
Medellin
$272 Roundtrip, just found
$272
Roundtrip
just found
Select Copa flight, departing Wed, Nov 12 from Panama City to Medellin, returning Wed, Nov 19, priced at $272 just found
Copa
Wed, Nov 5 - Sat, Nov 8
PTY
Panama City
MDE
Medellin
$275 Roundtrip, found 1 hour ago
$275
Roundtrip
found 1 hour ago
Select Copa flight, departing Wed, Nov 5 from Panama City to Medellin, returning Sat, Nov 8, priced at $275 found 1 hour ago
avianca
Thu, Dec 11 - Sat, Dec 13
PTY
Panama City
MDE
Medellin
$280 Roundtrip, found 11 hours ago
$280
Roundtrip
found 11 hours ago
Select avianca flight, departing Thu, Dec 11 from Panama City to Medellin, returning Sat, Dec 13, priced at $280 found 11 hours ago
Copa
Mon, Feb 16 - Sat, Feb 21
PTY
Panama City
MDE
Medellin
$282 Roundtrip, found 5 days ago
$282
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Feb 16 from Panama City to Medellin, returning Sat, Feb 21, priced at $282 found 5 days ago

Find the cheapest month to fly from Panama City (PTY) to Medellín (MDE)

December is typically the cheapest month to fly

From $185 - $349 per traveler.

Alternative airports near Medellín

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Enrique Olaya Herrera EOH. Closest option available. Average driving time to city center is 4 minutes. Flights from $415
EOH
Enrique Olaya Herrera
Closest
Average driving time to city center4 min
Flights from $415
Flights from Panama City (PTY) to Medellín (MDE)
Origin airport
Tocumen Intl.
Destination airport
José María Córdova Intl.
Airlines serving
Copa, avianca
Roundtrip price
$223
Distance
336 mi
Average flight time
1 hour 23 mins

Panama City to Medellín Flights

The cheapest times to fly from Panama City to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Medellín are during the month of November. You can find some of the cheapest flights from Panama City to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Medellín

Sunday is one of the best days to book for cheap flights from Panama City to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $121 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) cost?
Secure a cheap one-way flight from $121 or cheap return flight from $224 from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
The cheapest month to fly from PTY to MDE is November, when there's less demand. Off-peak season is typically when better flight deals are available between these airports.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Hop on a nonstop flight with Copa Airlines and go straight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE).
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
The cheapest airline to offer flights between Tocumen Intl. Airport (PTY) and Jose Maria Cordova Intl. Airport (MDE) will change depending on when you want to travel. AVIANCA and Copa Airlines are just some good options offering well-priced fares. Use Expedia's search tool to compare airlines in one place and find the right PTY to MDE flight for your budget.
How many flights per day from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
With an average of 9 nonstop flights that operate from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) every day, you'll be taking off on vacation soon enough.
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Flights between PTY and MDE are their busiest at 9 AM. For a less crowded experience and possibly cheaper prices, look for a time when demand is lower.
What day of the week has the most flights from PTY to MDE?
Friday offers the most flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE). Consider jetting off on this day and you'll have the best chance of finding a departure that fits your itinerary.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
The first flight of the day taking off from Tocumen Intl. Airport (PTY) is at around 7:01AM UTC-5. Catch this flight and you'll reach Jose Maria Cordova Intl. Airport (MDE) at approximately 8:23AM UTC-5. The entire trip takes 1h 22m.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Typically, it takes 1 hour and 22 minutes to cover the 340 mi from PTY to MDE.
What airline has the least delays from PTY to MDE?
Copa Airlines has the best performance for on-time direct flights from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE), with an on-time score of 92%. Use the Expedia App to view your flight status before you head off and get real-time alerts about any trip changes.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Medellin from Tocumen Intl. Airport (PTY)?
Compare your flight options from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE). This is the only Medellin airport you can land at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Last-minute fares from PTY to MDE are typically more expensive. To lock in the best rates, start looking for flights early. That said, if you can play around with your travel dates, it's possible to find a cheap fare right before your trip.
Is it cheaper to book a PTY to MDE flight and hotel package?
Opting for a PTY to MDE flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our wide range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Jose Maria Cordova Intl. Airport (MDE)?
If you reserved your PTY to MDE flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

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*Available to One Key members.