$170 Cheap Flights from Santo Domingo (SDQ) to St. Louis (STL)

View $170 flight on Thu, Dec 25, 2025Opens in a new window

Popular airlines from Las Americas Intl. Airport (SDQ) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Santo Domingo to St. Louis (SDQ-STL)

Prices were available within the past 7 days and start at $170 for one-way flights and $433 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Tue, Dec 30 - Sun, Jan 4
SDQ
Santo Domingo
STL
St. Louis
$433 Roundtrip, found 4 hours ago
$433
Roundtrip
found 4 hours ago
Select Spirit Airlines flight, departing Tue, Dec 30 from Santo Domingo to St. Louis, returning Sun, Jan 4, priced at $433 found 4 hours ago
Spirit Airlines
Thu, Dec 25 - Fri, Jan 2
SDQ
Santo Domingo
STL
St. Louis
$443 Roundtrip, found 4 days ago
$443
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Dec 25 from Santo Domingo to St. Louis, returning Fri, Jan 2, priced at $443 found 4 days ago
Spirit Airlines
Thu, Dec 25 - Fri, Jan 2
SDQ
Santo Domingo
STL
St. Louis
$460 Roundtrip, found 4 days ago
$460
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Thu, Dec 25 from Santo Domingo to St. Louis, returning Fri, Jan 2, priced at $460 found 4 days ago
Frontier Airlines
Mon, Dec 22 - Thu, Jan 1
SDQ
Santo Domingo
STL
St. Louis
$461 Roundtrip, found 3 days ago
$461
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Dec 22 from Santo Domingo to St. Louis, returning Thu, Jan 1, priced at $461 found 3 days ago
American Airlines
Sat, Dec 27 - Tue, Jan 6
SDQ
Santo Domingo
STL
St. Louis
$504 Roundtrip, found 1 day ago
$504
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 27 from Santo Domingo to St. Louis, returning Tue, Jan 6, priced at $504 found 1 day ago
Spirit Airlines
Tue, Dec 30 - Sun, Jan 4
SDQ
Santo Domingo
STL
St. Louis
$517 Roundtrip, found 4 hours ago
$517
Roundtrip
found 4 hours ago
Select Spirit Airlines flight, departing Tue, Dec 30 from Santo Domingo to St. Louis, returning Sun, Jan 4, priced at $517 found 4 hours ago
American Airlines
Sat, Dec 27 - Tue, Jan 6
SDQ
Santo Domingo
STL
St. Louis
$518 Roundtrip, found 1 day ago
$518
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 27 from Santo Domingo to St. Louis, returning Tue, Jan 6, priced at $518 found 1 day ago
Frontier Airlines
Mon, Dec 22 - Thu, Jan 1
SDQ
Santo Domingo
STL
St. Louis
$520 Roundtrip, found 3 days ago
$520
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Dec 22 from Santo Domingo to St. Louis, returning Thu, Jan 1, priced at $520 found 3 days ago
United
Mon, Dec 22 - Thu, Jan 1
SDQ
Santo Domingo
STL
St. Louis
$532 Roundtrip, found 3 days ago
$532
Roundtrip
found 3 days ago
Select United flight, departing Mon, Dec 22 from Santo Domingo to St. Louis, returning Thu, Jan 1, priced at $532 found 3 days ago
Delta
Thu, Apr 9 - Mon, Apr 20
SDQ
Santo Domingo
STL
St. Louis
$575 Roundtrip, found 2 days ago
$575
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Apr 9 from Santo Domingo to St. Louis, returning Mon, Apr 20, priced at $575 found 2 days ago

Find the cheapest month to fly from Santo Domingo (SDQ) to St. Louis (STL)

December is typically the cheapest month to fly

From $362 - $977 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $627
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $627

Frequently asked questions

How much does a flight from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL) cost?
Snag a cheap one-way flight from $170 or cheap return flight from $433 from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL)?
December is the most affordable month to fly from SDQ to STL. Planning your trip for the off-season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL)?
To find the cheapest airline that'll fly you from SDQ to STL, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL)?
Direct flights from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SDQ to STL?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL)?
To land at Lambert-St. Louis Intl. Airport (STL) without delays, choose a flight that leaves Las Americas Intl. Airport (SDQ) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your trip to book a flight from SDQ to STL generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Be flexible with your travel plans for a better chance of getting a bargain.
Is it cheaper to book a SDQ to STL flight and hotel package?
Compared with arranging hotels and flights separately, booking a SDQ to STL flight and hotel package with Expedia could lead to significant savings. Better still, managing everything in one place will take the hassle out of planning your trip. Simply pick your flights and choose from our wide range of hotels, then tailor your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from Las Americas Intl. Airport (SDQ) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your SDQ to STL flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Origin airport
Las Americas Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Copa, Delta, Frontier Airlines, United
Roundtrip price
$433
Distance
1873 mi

Book with confidence

Santo Domingo to St. Louis Flights

The cheapest times to fly from Santo Domingo to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santo Domingo to St. Louis are during the month of December. You can find some of the cheapest flights from Santo Domingo to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santo Domingo to St. Louis

Sunday is one of the best days to book for cheap flights from Santo Domingo to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santo Domingo to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santo Domingo to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $170 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santo Domingo to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santo Domingo to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santo Domingo to St. Louis Flights

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*Available to One Key members.