$174 Cheap American Airlines flights Knoxville (TYS) to Detroit (DTW)

You'll find cheap round-trip American Airlines flights from $269 from TYS to DTW by filtering your results from "Price (lowest to highest)" on Expedia. Or look for bargains from $174 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for affordable American Airlines flights from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW) one to three months prior to your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the best day of the week to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from TYS to DTW with American Airlines, filter your search by "Early Morning" and "Morning." Choosing an early flight usually means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.