$157 Cheap American Airlines flights Minneapolis (MSP) to San Diego (SAN)

Grab cheap return American Airlines flights from $201 from MSP to SAN by organizing your results from “Price (lowest to highest)” on Expedia. Or search for bargains from $157 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are often cheaper in the off-peak months of January and November. Whether you need a one-way or a return ticket, you could score a better deal then.

For cheap American Airlines fares from Minneapolis - St. Paul Intl. Airport (MSP) to San Diego Intl. Airport (SAN), start searching one to three months before your planned departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your trip on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Enter your dates, press search and check the “Nonstop” filter on Expedia to find any direct flights from MSP to SAN with American Airlines or other airlines.

Sort your results by “Morning” and “Early Morning” to browse the earliest departures from MSP to SAN. Setting off early means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Minneapolis - St. Paul Intl. Airport (MSP) to San Diego touch down at San Diego Intl. Airport (SAN). This is the main gateway to this destination.

It’s generally possible to cancel or change your flight, although additional fees may apply if your booking was made more than 24 hours ago. Need to keep your options open? Use our “No cancel fee” and “Changes included” filters to find flights that won’t charge you extra if you need to alter your plans. To modify your itinerary, go to “Trips,” select your flight and click on “Manage Booking” for more information.