$158 Cheap Flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)

View $158 flight on Fri, Aug 15, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Myrtle Beach to Santo Domingo (MYR-SDQ)

Prices were available within the past 7 days and start at $158 for one-way flights and $348 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Mon, Aug 4 - Wed, Aug 13
MYR
Myrtle Beach
SDQ
Santo Domingo
$348 Roundtrip, found 1 day ago
$348
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Aug 4 from Myrtle Beach to Santo Domingo, returning Wed, Aug 13, priced at $348 found 1 day ago
Spirit Airlines
Mon, Aug 4 - Wed, Aug 13
MYR
Myrtle Beach
SDQ
Santo Domingo
$361 Roundtrip, found 1 day ago
$361
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Aug 4 from Myrtle Beach to Santo Domingo, returning Wed, Aug 13, priced at $361 found 1 day ago
Spirit Airlines
Mon, Jul 7 - Sun, Sep 7
MYR
Myrtle Beach
SDQ
Santo Domingo
$378 Roundtrip, found 2 days ago
$378
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Mon, Jul 7 from Myrtle Beach to Santo Domingo, returning Sun, Sep 7, priced at $378 found 2 days ago
Spirit Airlines
Mon, Aug 11 - Fri, Aug 15
MYR
Myrtle Beach
SDQ
Santo Domingo
$388 Roundtrip, found 4 days ago
$388
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Mon, Aug 11 from Myrtle Beach to Santo Domingo, returning Fri, Aug 15, priced at $388 found 4 days ago
Frontier Airlines
Mon, Aug 4 - Wed, Aug 13
MYR
Myrtle Beach
SDQ
Santo Domingo
$390 Roundtrip, found 1 day ago
$390
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Aug 4 from Myrtle Beach to Santo Domingo, returning Wed, Aug 13, priced at $390 found 1 day ago
Spirit Airlines
Mon, Aug 11 - Mon, Aug 18
MYR
Myrtle Beach
SDQ
Santo Domingo
$391 Roundtrip, found 6 days ago
$391
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Mon, Aug 11 from Myrtle Beach to Santo Domingo, returning Mon, Aug 18, priced at $391 found 6 days ago
Spirit Airlines
Mon, Jul 7 - Fri, Jul 11
MYR
Myrtle Beach
SDQ
Santo Domingo
$398 Roundtrip, found 2 hours ago
$398
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Mon, Jul 7 from Myrtle Beach to Santo Domingo, returning Fri, Jul 11, priced at $398 found 2 hours ago
Delta
Mon, Sep 8 - Tue, Sep 16
MYR
Myrtle Beach
SDQ
Santo Domingo
$465 Roundtrip, found 22 hours ago
$465
Roundtrip
found 22 hours ago
Select Delta flight, departing Mon, Sep 8 from Myrtle Beach to Santo Domingo, returning Tue, Sep 16, priced at $465 found 22 hours ago
United
Mon, Sep 8 - Tue, Sep 16
MYR
Myrtle Beach
SDQ
Santo Domingo
$465 Roundtrip, found 22 hours ago
$465
Roundtrip
found 22 hours ago
Select United flight, departing Mon, Sep 8 from Myrtle Beach to Santo Domingo, returning Tue, Sep 16, priced at $465 found 22 hours ago
American Airlines
Mon, Sep 8 - Tue, Sep 16
MYR
Myrtle Beach
SDQ
Santo Domingo
$469 Roundtrip, found 22 hours ago
$469
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Mon, Sep 8 from Myrtle Beach to Santo Domingo, returning Tue, Sep 16, priced at $469 found 22 hours ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Santo Domingo (SDQ)

September is typically the cheapest month to fly

From $270 - $674 per traveler.

Graph displaying average flight prices per month

Flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)
Origin airport
Myrtle Beach Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Spirit Airlines, United
Roundtrip price
$348
Distance
1198 mi

Myrtle Beach to Santo Domingo Flights

The cheapest times to fly from Myrtle Beach to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Santo Domingo are during the month of August. You can find some of the cheapest flights from Myrtle Beach to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Santo Domingo

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $158 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ) cost?
Discover the latest flight deals from MYR to SDQ by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MYR to SDQ?
The cheapest flights from MYR to SDQ are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MYR to SDQ?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MYR to SDQ. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ)?
You'll need to catch a flight with a layover when traveling from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from MYR to SDQ?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ)?
To touch down at Las Americas Intl. Airport (SDQ) without delays, pick a flight that leaves Myrtle Beach Intl. Airport (MYR) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ) last-minute?
Waiting until just before your departure to book a ticket from MYR to SDQ often results in higher prices. While you may find some last-minute offers, they aren't always guaranteed. Allow some flexibility in your schedule to boost your chances of snagging a bargain.
Is it cheaper to book a MYR to SDQ flight and hotel package?
Compared with arranging hotels and flights separately, booking a MYR to SDQ flight and hotel package with Expedia could lead to significant savings. What's more, having it all in one place will take the hassle out of travel planning. Simply secure your flights and choose from our wide range of stays, then customize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Las Americas Intl. Airport (SDQ)?
You can usually cancel or reschedule your MYR to SDQ flight. However, for bookings made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.