$109 Cheap Flights from Myrtle Beach (MYR) to St. Louis (STL)

View $109 flight on Sat, Oct 11, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Myrtle Beach to St. Louis (MYR-STL)

Prices were available within the past 7 days and start at $109 for one-way flights and $218 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Sat, Oct 25 - Sun, Nov 2
MYR
Myrtle Beach
STL
St. Louis
$218 Roundtrip, just found
$218
Roundtrip
just found
Select Spirit Airlines flight, departing Sat, Oct 25 from Myrtle Beach to St. Louis, returning Sun, Nov 2, priced at $218 just found
American Airlines
Thu, Oct 23 - Sun, Oct 26
MYR
Myrtle Beach
STL
St. Louis
$267 Roundtrip, found 5 days ago
$267
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Oct 23 from Myrtle Beach to St. Louis, returning Sun, Oct 26, priced at $267 found 5 days ago
Southwest Airlines
Tue, Dec 23 - Tue, Dec 30
MYR
Myrtle Beach
STL
St. Louis
$271 Roundtrip, found 4 days ago
$271
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Tue, Dec 23 from Myrtle Beach to St. Louis, returning Tue, Dec 30, priced at $271 found 4 days ago
Southwest Airlines
Tue, Oct 7 - Thu, Oct 9
MYR
Myrtle Beach
STL
St. Louis
$273 Roundtrip, found 6 days ago
$273
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Tue, Oct 7 from Myrtle Beach to St. Louis, returning Thu, Oct 9, priced at $273 found 6 days ago
Southwest Airlines
Wed, Oct 22 - Sun, Oct 26
MYR
Myrtle Beach
STL
St. Louis
$274 Roundtrip, found 1 hour ago
$274
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to St. Louis, returning Sun, Oct 26, priced at $274 found 1 hour ago
American Airlines
Thu, Jan 8 - Tue, Jan 13
MYR
Myrtle Beach
STL
St. Louis
$276 Roundtrip, found 5 days ago
$276
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Jan 8 from Myrtle Beach to St. Louis, returning Tue, Jan 13, priced at $276 found 5 days ago
American Airlines
Thu, Oct 23 - Sun, Oct 26
MYR
Myrtle Beach
STL
St. Louis
$278 Roundtrip, found 5 days ago
$278
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Oct 23 from Myrtle Beach to St. Louis, returning Sun, Oct 26, priced at $278 found 5 days ago
Southwest Airlines
Wed, Oct 22 - Sun, Oct 26
MYR
Myrtle Beach
STL
St. Louis
$279 Roundtrip, found 1 hour ago
$279
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to St. Louis, returning Sun, Oct 26, priced at $279 found 1 hour ago
Delta
Wed, Oct 15 - Wed, Oct 22
MYR
Myrtle Beach
STL
St. Louis
$325 Roundtrip, found 20 hours ago
$325
Roundtrip
found 20 hours ago
Select Delta flight, departing Wed, Oct 15 from Myrtle Beach to St. Louis, returning Wed, Oct 22, priced at $325 found 20 hours ago
United
Sat, Oct 18 - Mon, Oct 20
MYR
Myrtle Beach
STL
St. Louis
$340 Roundtrip, found 1 day ago
$340
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 18 from Myrtle Beach to St. Louis, returning Mon, Oct 20, priced at $340 found 1 day ago

Find the cheapest month to fly from Myrtle Beach (MYR) to St. Louis (STL)

September is typically the cheapest month to fly

From $158 - $526 per traveler.

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Grab a cheap one-way flight from $109 or cheap return flight from $218 from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
October is the most affordable month to fly from MYR to STL. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MYR to STL. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to STL?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from MYR to STL?
Consider traveling with United Airlines if you'd like to fly straight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) without any delays. This carrier has the strongest track record for punctuality, with an on-time score of 100%. Want to get notified of any changes? You can check your flight status using the Expedia App.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute bookings from MYR to STL are typically more expensive. To secure the best rates, start looking for flights ahead of time. That said, if your travel plans are flexible, you may find a cheap ticket right before you leave.
Is it cheaper to book a MYR to STL flight and hotel package?
Securing a MYR to STL flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our impressive range of stays and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your MYR to STL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, Spirit Airlines, United
Roundtrip price
$218
Distance
726 mi
Average flight time
2 hours 5 mins

Book with confidence

Book with confidence

Myrtle Beach to St. Louis Flights

The cheapest times to fly from Myrtle Beach to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to St. Louis are during the month of October. You can find some of the cheapest flights from Myrtle Beach to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to St. Louis

Sunday is one of the best days to book for cheap flights from Myrtle Beach to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $109 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to St. Louis Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.