$110 Cheap Flights from Myrtle Beach (MYR) to St. Louis (STL)

View $110 flight on Thu, Dec 4, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Myrtle Beach to St. Louis (MYR-STL)

Prices were available within the past 7 days and start at $110 for one-way flights and $292 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 23 - Tue, Dec 30
MYR
Myrtle Beach
STL
St. Louis
$292 Roundtrip, found 6 days ago
$292
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 23 from Myrtle Beach to St. Louis, returning Tue, Dec 30, priced at $292 found 6 days ago
Southwest Airlines
Tue, Dec 23 - Tue, Dec 30
MYR
Myrtle Beach
STL
St. Louis
$297 Roundtrip, found 6 days ago
$297
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Tue, Dec 23 from Myrtle Beach to St. Louis, returning Tue, Dec 30, priced at $297 found 6 days ago
Spirit Airlines
Thu, Dec 4 - Sun, Dec 7
MYR
Myrtle Beach
STL
St. Louis
$318 Roundtrip, just found
$318
Roundtrip
just found
Select Spirit Airlines flight, departing Thu, Dec 4 from Myrtle Beach to St. Louis, returning Sun, Dec 7, priced at $318 just found
Delta
Tue, Jan 13 - Wed, Jan 28
MYR
Myrtle Beach
STL
St. Louis
$323 Roundtrip, found 15 hours ago
$323
Roundtrip
found 15 hours ago
Select Delta flight, departing Tue, Jan 13 from Myrtle Beach to St. Louis, returning Wed, Jan 28, priced at $323 found 15 hours ago
Delta
Sat, Jan 17 - Wed, Jan 28
MYR
Myrtle Beach
STL
St. Louis
$324 Roundtrip, found 15 hours ago
$324
Roundtrip
found 15 hours ago
Select Delta flight, departing Sat, Jan 17 from Myrtle Beach to St. Louis, returning Wed, Jan 28, priced at $324 found 15 hours ago
Delta
Wed, Dec 31 - Sun, Jan 18
MYR
Myrtle Beach
STL
St. Louis
$325 Roundtrip, found 15 hours ago
$325
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, Dec 31 from Myrtle Beach to St. Louis, returning Sun, Jan 18, priced at $325 found 15 hours ago
Delta
Tue, Dec 23 - Tue, Dec 30
MYR
Myrtle Beach
STL
St. Louis
$327 Roundtrip, found 6 days ago
$327
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 23 from Myrtle Beach to St. Louis, returning Tue, Dec 30, priced at $327 found 6 days ago
Southwest Airlines
Tue, Feb 3 - Tue, Feb 10
MYR
Myrtle Beach
STL
St. Louis
$328 Roundtrip, found 22 hours ago
$328
Roundtrip
found 22 hours ago
Select Southwest Airlines flight, departing Tue, Feb 3 from Myrtle Beach to St. Louis, returning Tue, Feb 10, priced at $328 found 22 hours ago
American Airlines
Tue, Feb 3 - Tue, Feb 10
MYR
Myrtle Beach
STL
St. Louis
$330 Roundtrip, found 22 hours ago
$330
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Tue, Feb 3 from Myrtle Beach to St. Louis, returning Tue, Feb 10, priced at $330 found 22 hours ago
United
Tue, Feb 3 - Tue, Feb 10
MYR
Myrtle Beach
STL
St. Louis
$336 Roundtrip, found 22 hours ago
$336
Roundtrip
found 22 hours ago
Select United flight, departing Tue, Feb 3 from Myrtle Beach to St. Louis, returning Tue, Feb 10, priced at $336 found 22 hours ago

Find the cheapest month to fly from Myrtle Beach (MYR) to St. Louis (STL)

September is typically the cheapest month to fly

From $158 - $436 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $400
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $400

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Grab a cheap one-way flight from $110 or cheap return flight from $292 from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
December is the most affordable month to fly from MYR to STL. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MYR to STL. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to STL?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from MYR to STL?
Consider traveling with United Airlines if you'd like to fly straight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) without any delays. This carrier has the strongest track record for punctuality, with an on-time score of 100%. Want to get notified of any changes? You can check your flight status using the Expedia App.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute bookings from MYR to STL are typically more expensive. To secure the best rates, start looking for flights ahead of time. That said, if your travel plans are flexible, you may find a cheap ticket right before you leave.
Is it cheaper to book a MYR to STL flight and hotel package?
Securing a MYR to STL flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our impressive range of stays and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your MYR to STL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$291
Distance
726 mi

Book with confidence

Myrtle Beach to St. Louis Flights

The cheapest times to fly from Myrtle Beach to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to St. Louis are during the month of December. You can find some of the cheapest flights from Myrtle Beach to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to St. Louis

Sunday is one of the best days to book for cheap flights from Myrtle Beach to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $110 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to St. Louis Flights

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*Available to One Key members.