$378 Cheap Flights from Fort Myers (RSW) to La Crosse (LSE)

View $378 flight on Tue, Jan 6, 2026Opens in a new window

Popular airlines from Southwest Florida Intl. Airport (RSW) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Fort Myers to La Crosse (RSW-LSE)

Prices were available within the past 7 days and start at $378 for one-way flights and $410 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Nov 25 - Tue, Dec 2
RSW
Fort Myers
LSE
La Crosse
$410 Roundtrip, found 1 day ago
$410
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Fort Myers to La Crosse, returning Tue, Dec 2, priced at $410 found 1 day ago
American Airlines
Wed, Dec 10 - Mon, Dec 15
RSW
Fort Myers
LSE
La Crosse
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 10 from Fort Myers to La Crosse, returning Mon, Dec 15, priced at $437 found 2 days ago
American Airlines
Tue, Nov 25 - Tue, Dec 2
RSW
Fort Myers
LSE
La Crosse
$449 Roundtrip, found 1 day ago
$449
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Fort Myers to La Crosse, returning Tue, Dec 2, priced at $449 found 1 day ago
American Airlines
Tue, Nov 25 - Tue, Dec 2
RSW
Fort Myers
LSE
La Crosse
$490 Roundtrip, found 1 day ago
$490
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Fort Myers to La Crosse, returning Tue, Dec 2, priced at $490 found 1 day ago
American Airlines
Tue, Nov 25 - Tue, Dec 2
RSW
Fort Myers
LSE
La Crosse
$492 Roundtrip, found 1 day ago
$492
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 25 from Fort Myers to La Crosse, returning Tue, Dec 2, priced at $492 found 1 day ago
American Airlines
Wed, Dec 10 - Tue, Dec 16
RSW
Fort Myers
LSE
La Crosse
$496 Roundtrip, found 2 days ago
$496
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 10 from Fort Myers to La Crosse, returning Tue, Dec 16, priced at $496 found 2 days ago
American Airlines
Thu, Dec 25 - Wed, Jan 7
RSW
Fort Myers
LSE
La Crosse
$500 Roundtrip, found 5 days ago
$500
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Dec 25 from Fort Myers to La Crosse, returning Wed, Jan 7, priced at $500 found 5 days ago
American Airlines
Tue, Dec 23 - Tue, Jan 6
RSW
Fort Myers
LSE
La Crosse
$509 Roundtrip, found 5 days ago
$509
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 23 from Fort Myers to La Crosse, returning Tue, Jan 6, priced at $509 found 5 days ago
American Airlines
Sat, Sep 27 - Sat, Oct 4
RSW
Fort Myers
LSE
La Crosse
$510 Roundtrip, found 4 days ago
$510
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Sep 27 from Fort Myers to La Crosse, returning Sat, Oct 4, priced at $510 found 4 days ago
American Airlines
Tue, Dec 23 - Tue, Jan 6
RSW
Fort Myers
LSE
La Crosse
$513 Roundtrip, found 5 days ago
$513
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 23 from Fort Myers to La Crosse, returning Tue, Jan 6, priced at $513 found 5 days ago
Flights from Fort Myers (RSW) to La Crosse (LSE)
Origin airport
Southwest Florida Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$410
Distance
1311 mi

Fort Myers to La Crosse Flights

The cheapest times to fly from Fort Myers to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Fort Myers to La Crosse are during the month of November. You can find some of the cheapest flights from Fort Myers to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Fort Myers to La Crosse

Sunday is one of the best days to book for cheap flights from Fort Myers to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Fort Myers to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Fort Myers to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $378 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Fort Myers to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Fort Myers to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE) cost?
Snag a cheap one-way flight from $378 or cheap return flight from $410 from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE)?
Flying in November may help you find better deals, as it's the cheapest month for flights between RSW and LSE. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest RSW to LSE flight.
How many flights per day from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE)?
You'll need to catch a flight with a layover when traveling from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE). There are no daily direct flights on this route. However, just filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from RSW to LSE?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE)?
Choose a flight from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE) last-minute?
Last-minute fares from RSW to LSE are generally more expensive. For the cheapest rates, start searching for flights early. That said, if your travel plans are flexible, it's possible to land a cheap fare right before you leave.
Is it cheaper to book a RSW to LSE flight and hotel package?
You can save money by booking a RSW to LSE flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your ideal flights and accommodations, you can add extras such as tours, car rentals and activities.
Can I cancel or change the date of my flight from Southwest Florida Intl. Airport (RSW) to La Crosse Municipal Airport (LSE)?
If you booked your RSW to LSE flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

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*Available to One Key members.