$378 Cheap Flights from St. Louis (STL) to La Crosse (LSE)

View $378 flight on Sat, Nov 8, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from St. Louis to La Crosse (STL-LSE)

Prices were available within the past 7 days and start at $378 for one-way flights and $468 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Apr 28 - Tue, May 12
STL
St. Louis
LSE
La Crosse
$468 Roundtrip, found 6 days ago
$468
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Apr 28 from St. Louis to La Crosse, returning Tue, May 12, priced at $468 found 6 days ago
American Airlines
Tue, Apr 7 - Wed, Apr 22
STL
St. Louis
LSE
La Crosse
$474 Roundtrip, found 6 days ago
$474
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Apr 7 from St. Louis to La Crosse, returning Wed, Apr 22, priced at $474 found 6 days ago
American Airlines
Wed, Nov 19 - Tue, Nov 25
STL
St. Louis
LSE
La Crosse
$474 Roundtrip, found 8 hours ago
$474
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Nov 19 from St. Louis to La Crosse, returning Tue, Nov 25, priced at $474 found 8 hours ago
American Airlines
Tue, Apr 28 - Sat, May 9
STL
St. Louis
LSE
La Crosse
$480 Roundtrip, found 6 days ago
$480
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Apr 28 from St. Louis to La Crosse, returning Sat, May 9, priced at $480 found 6 days ago
American Airlines
Sat, May 2 - Wed, May 20
STL
St. Louis
LSE
La Crosse
$486 Roundtrip, found 6 days ago
$486
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 2 from St. Louis to La Crosse, returning Wed, May 20, priced at $486 found 6 days ago
American Airlines
Sat, May 2 - Sun, May 17
STL
St. Louis
LSE
La Crosse
$488 Roundtrip, found 6 days ago
$488
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 2 from St. Louis to La Crosse, returning Sun, May 17, priced at $488 found 6 days ago
American Airlines
Wed, May 13 - Tue, Jun 2
STL
St. Louis
LSE
La Crosse
$492 Roundtrip, found 6 days ago
$492
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, May 13 from St. Louis to La Crosse, returning Tue, Jun 2, priced at $492 found 6 days ago
American Airlines
Sat, May 30 - Sat, Jun 13
STL
St. Louis
LSE
La Crosse
$493 Roundtrip, found 6 days ago
$493
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 30 from St. Louis to La Crosse, returning Sat, Jun 13, priced at $493 found 6 days ago
American Airlines
Tue, May 5 - Wed, May 20
STL
St. Louis
LSE
La Crosse
$498 Roundtrip, found 6 days ago
$498
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, May 5 from St. Louis to La Crosse, returning Wed, May 20, priced at $498 found 6 days ago
American Airlines
Tue, May 5 - Sun, May 17
STL
St. Louis
LSE
La Crosse
$500 Roundtrip, found 6 days ago
$500
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, May 5 from St. Louis to La Crosse, returning Sun, May 17, priced at $500 found 6 days ago

Alternative airports near La Crosse

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Crosse Municipal LSE. Cheapest and Closest option available. Average driving time to city center is 12 minutes. Flights from $474
LSE
La Crosse Municipal
CheapestClosest
Average driving time to city center12 min
Flights from $474

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE) cost?
Secure a cheap one-way flight from $378 or cheap return flight from $468 from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE)?
The cheapest month to fly from STL to LSE is April, when demand is low. Off-peak months are typically when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest STL to LSE flight.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE)?
Nonstop flights from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from STL to LSE?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE)?
To reach La Crosse Municipal Airport (LSE) without delays, pick a flight that takes off from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE) last-minute?
Last-minute fares from STL to LSE are typically more expensive. To lock in the cheapest rates, start searching for flights well ahead of time. That said, if you're flexible with your travel plans, you may score a cheap ticket right before you leave.
Is it cheaper to book a STL to LSE flight and hotel package?
Opting for a STL to LSE flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Choose from our extensive range of hotels and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to La Crosse Municipal Airport (LSE)?
Typically, you can cancel or modify your STL to LSE flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you want further details, head to our Customer Service portal.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$468
Distance
357 mi

Book with confidence

St. Louis to La Crosse Flights

The cheapest times to fly from St. Louis to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to La Crosse are during the month of April. You can find some of the cheapest flights from St. Louis to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to La Crosse

Sunday is one of the best days to book for cheap flights from St. Louis to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $378 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to La Crosse Flights

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*Available to One Key members.