You may spot St. Johns Cathedral in the skyline before you actually find this grand building. Peek inside if the doors are open or just take in the facade from the street.
You're spoiled for sightseeing choice when staying in 's-Hertogenbosch. St. John's Cathedral is a good place to kick off here, but there are plenty of other interesting places to consider. National Park de Loonse en Drunense Duinen, Iron Man Beach, and Noordbrabants Museum are not far from the principal church and will fill in your day nicely.