Cayo Guillermo Vacations from $358

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Your Cayo Guillermo Vacation

Unforgettable adventures await when you lock in a Cayo Guillermo vacation package. Whether you're a foodie, art enthusiast or just a traveler who loves to see new places, there's something for everyone in this interesting city. There's plenty to put on your must-do list during a trip to Cayo Guillermo, beginning with popular sights such as Cayo Guillermo Beach and Cayo Guillermo Marina. Stop daydreaming and start doing. Check out the wide range of options on Expedia today and put your Cayo Guillermo vacation plans into motion!

The Latest Cayo Guillermo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
ABAE Hotel by Eskape Collection

ABAE Hotel by Eskape Collection

3.5 out of 5
South Beach
Save 100% on your flight
per person
Jul 18 - Jul 22
found 9 hours ago
Roundtrip flight included
New York (NYC) to Miami (MIA)
8.6/10 Excellent! (1,004 reviews)
We enjoyed our quick one night stay. The neighbourhood was safe and quiet and had a coffee shop right next to the lobby.

Reviewed on Apr 30, 2024

The Retreat Collection at 1 Hotel & Homes South Beach

The Retreat Collection at 1 Hotel & Homes South Beach

5 out of 5
South Beach
per person
Jul 30 - Aug 2
found 1 day ago
Roundtrip flight included
Newark (EWR) to Miami (MIA)
8/10 Very Good! (1 review)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
South Beach
per person
Aug 6 - Aug 9
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Miami (MIA)
9/10 Wonderful! (1,006 reviews)
Beautiful stay!! Nice atmosphere

Reviewed on May 23, 2024

The Westin New York Grand Central

The Westin New York Grand Central

4.5 out of 5
Manhattan
Save 100% on your flight
per person
Jul 10 - Jul 14
found 20 hours ago
Roundtrip non-stop flight included
Dallas (DAL) to New York (JFK)
8.8/10 Excellent! (2,398 reviews)
Check in took a very long time

Reviewed on May 24, 2024

Cavalier Hotel South Beach

Cavalier Hotel South Beach

3.5 out of 5
South Beach
Save 100% on your flight
per person
Jun 27 - Jul 1
found 23 hours ago
Roundtrip flight included
Dallas (DFW) to Miami (MIA)
8.2/10 Very Good! (1,000 reviews)
Clean, quiet, friendly staff.

Reviewed on May 23, 2024

Cayo Guillermo Beach Vacation

Escape the stresses of daily life and unwind on your Cayo Guillermo vacation. There's nothing more rejuvenating than the salty sea air and the soothing sound of waves breaking onto the shore. Organize your trip to Cayo Guillermo the quick and easy way by booking one of our Cayo Guillermo vacation packages. Many people decide to stay near Cayo Guillermo Beach, a local highlight just 2 miles (3 km) from the city center.

Things You Should Know About Cayo Guillermo

Cayo Guillermo Essential Information

Language
Spanish
Currency
Cuban pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Santa Clara Airport (SNU)
Max Temp Winter
80ºF
Max Temp Summer
90ºF
Top Sights
Cayo Guillermo Beach and Cayo Guillermo Marina

Cayo Guillermo Hotel Deals

Hotel Grand Muthu Cayo Guillermo
Hotel Grand Muthu Cayo Guillermo
3.5 out of 5
Cayo Guillermo, Cayo Guillermo, Ciego de Avila
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Hotel Grand Muthu Cayo Guillermo
Villa Gregorio
Villa Gregorio
2.5 out of 5
Carretera a Cayo Guillermo, Cayo Guillermo, Ciego de Avila
7.6/10 Good! (9 reviews)
"Zimmer ohne Fenster, schlechte ölige Pommes, unfreundliches Personal"

Reviewed on Mar 20, 2020

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Villa Gregorio
Iberostar Daiquirí - All inclusive
Iberostar Daiquirí - All inclusive
4 out of 5
Cayo Guillermo, Jardines del Rey, Moron Ciego de Avila, Cayo Guillermo, Ciego de Avila
6.6/10 (41 reviews)
"The location of the hotel, staff, food and entertainment are great. We felt it’s a well designed hotel (Believe just over 300 rooms) as it never felt overcrowded nor overlooked. The staff are wonderfully helpful and friendly and plenty around."

Reviewed on Mar 2, 2020

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Iberostar Daiquirí - All inclusive
See all 7 properties in Cayo Guillermo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Frequently asked questions

How much does a Cayo Guillermo vacation package cost?
Explore the best of Cayo Guillermo from as little as $358. We offer a wonderful selection of flights, rental cars and hotels to suit your travel style. Score even better deals when you add some activities or tours to your vacation package.
How do I get a cheap travel package to Cayo Guillermo?
Bundle your flights and hotels with Expedia to save big on your next adventure. With over 550 partner airlines and 1,000,000 hotels worldwide, your Cayo Guillermo vacation package can be customized exactly to suit your budget. With all that extra money, why not throw in some exciting tours and experiences? It’s an easy way to unlock even more bargains. Your dream vacation in Cayo Guillermo is much closer than you thought!
How far in advance should I book my Cayo Guillermo vacation?
You’ll be rewarded with the widest variety and the lowest prices by booking your Cayo Guillermo vacation early. Airlines usually sell tickets around 12 months prior to departure, so start your planning ASAP. That being said, Expedia is dedicated to giving you the best deals around, so it’s never a bad time to book your dream vacation!
What does an Expedia Cayo Guillermo travel package include?
It comes down to what you’re looking for. If you’re traveling alone, you might decide to bundle hotels and flights. Bringing the entire family to Cayo Guillermo? A travel package that includes hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to customize your travel package.
What should I know before booking a Cayo Guillermo travel package?
Get set to save with an Expedia travel package. Combine your airfares, rental cars and hotels and unlock exciting discounts. Hotels aren’t your only option, though. Book with us and choose from beachfront villas, city apartments and even ranches and treehouses!
Can I choose my airline with a Cayo Guillermo Expedia vacation package?
You sure can. Expedia has access to more than 550 partner airlines globally, so pick the carrier that suits your budget needs.
If I'm not able to travel, can I cancel my Cayo Guillermo vacation package?
Don’t stress if you’re rethinking your Cayo Guillermo vacation package — it’s possible to change or amend your booking. And if you’ve booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We know life can sometimes throw a spanner in the works, so head to our Customer Service Portal if that occurs. When you’re ready to make changes, we’re here to help.

Discover the most popular places to visit in Cayo Guillermo

Image for Cayo Guillermo Beach

Cayo Guillermo Beach

5/5(7 reviews)

Why not spend a carefree afternoon at Cayo Guillermo Beach during your travels in Cayo Guillermo? While you're in the area, wander around the natural setting.

Cayo Guillermo Beach
Image for Cayo Guillermo Marina

Cayo Guillermo Marina

4/5(2 reviews)

Cayo Guillermo Marina is just one of the places to see in Cayo Guillermo, so why not enjoy the other things to explore during your travels? While you're in the area, stroll along the white-sand beaches.

Cayo Guillermo Marina

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.