A historic stone fortress with a central dome and surrounding walls.

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Check availability on Colon 5 Star Hotels

Tonight
Oct 10 - Oct 11
Tomorrow
Oct 11 - Oct 12
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Our top choices for Colon 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern hotel room with a dining area, a TV, and a city view.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Avanel
$132 nightly
$145 total
Oct 21 - Oct 22
Total with taxes and fees
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
$263 nightly
$289 total
Oct 31 - Nov 1
Total with taxes and fees
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
$351 nightly
$386 total
Nov 3 - Nov 4
Total with taxes and fees
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern hotel entrance with a prominent 'Renaissance Hotel' sign, a well-lit outdoor area with a wooden structure, and a staircase leading to the upper floors.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
$135 nightly
$149 total
Oct 31 - Nov 1
Total with taxes and fees
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.
A terrace with seating and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Detra Dorsey
$279 nightly
$307 total
Nov 7 - Nov 8
Total with taxes and fees
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A spacious hotel lobby with modern furniture, large windows, and a city view.
A modern building with a sign reading 'HYATT REGENCY.'
A modern interior with a central seating area, potted plants, and a staircase.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
$187 nightly
$206 total
Oct 17 - Oct 18
Total with taxes and fees
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
A pool with a central water feature, surrounded by seating areas and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Carmen
$277 nightly
$304 total
Nov 1 - Nov 2
Total with taxes and fees
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A high-rise building with a rooftop pool area, surrounded by other buildings.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.

8. W Panama

W Panama
Bella Vista
United States
Naomi
$231 nightly
$254 total
Nov 1 - Nov 2
Total with taxes and fees
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A modern interior with a spiral staircase, a large window, and a seating area.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
$247 nightly
$272 total
Nov 6 - Nov 7
Total with taxes and fees
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Anna
$206 nightly
$227 total
Oct 25 - Oct 26
Total with taxes and fees
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
$249 nightly
$274 total
Oct 17 - Oct 18
Total with taxes and fees
Bristol Panama, a Registry Collection Hotel
Lobby
Bar (on property)
Outdoor pool
Banquet hall

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
$102 nightly
$112 total
Nov 5 - Nov 6
Total with taxes and fees
Waymore Hotel Spa and Casino
Terrace/patio
Casino
Room
Outdoor spa tub

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
$215 nightly
$237 total
Nov 10 - Nov 11
Total with taxes and fees
Megapolis Hotel Panamá
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Colon.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
$203 nightly
$223 total
Nov 9 - Nov 10
Total with taxes and fees
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
$133 nightly
$133 total
Oct 24 - Oct 25
Total with taxes and fees
8.6/10 Excellent! (1,776 reviews)
Megapolis Hotel Panamá
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Via Espana 111 Panama City Panama
$84 nightly
$92 total
Oct 27 - Oct 28
Total with taxes and fees
7.8/10 Good! (1,001 reviews)
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Colon

Explore the colorful Zona Libre free trade zone for duty-free shopping and visit the historic Colon 2000 cruise port. Discover Panama's colonial history at Fort San Lorenzo, located on the Caribbean coast outside the city.

See all hotels in Colon
A historic stone fortress with a central dome and surrounding walls.

Top Colon Hotel Reviews

Find out more about Colon

There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Colon by treating yourself to the best of the best when it comes to lodging. It's an ideal pairing. There's no reason to delay a getaway to Colon any longer. You'll join the multitudes of vacationers who have made Colon so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Book one of Expedia's luxurious 5-star hotels in Colon and get ready to be pampered like never before.

Book the Best Colon 5-Star Hotels

You'll have a wonderful time at one of these 5-star hotels. High-end restaurants, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. How do you want to relax? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

You won't sleep and order room service the entire time, though. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Colon are waiting for you to rest up after a busy day.

Make Your Escape

The results are in, and Colon 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of our Colon 5-star hotels today and relax in total tranquility tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Colon?
The amount you pay for a 5-star hotel in Colon depends on factors such as when you want to go and the length of your getaway. Our top tip for bagging the best deal? Use our pricing filters to compare the available accommodations for your chosen dates.
  • Search for the lowest price per night from $92
What makes a hotel 5 stars in Colon?
In Colon, a hotel needs to offer a specific level of upscale features to earn a 5-star rating. These may include on-site gyms, gourmet restaurants, saunas and spas, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their superior service. You can look forward to things like in-room massages, concierge services and nightly turn-down services. Some may also offer extra touches such as welcome gifts.
Are there any 5-star all-inclusive resorts in Colon?
Find a luxury escape that includes your lodging, food, activities and entertainment in Colon with the help of our filter tool. Search for resorts rated 5 stars and click on the "All inclusive" filter. Have a look at what's included in the price. This way, you can take full advantage of the many perks on offer from the moment you get there.

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