Colon Vacations from $629
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Colon Vacation
With one of our vacation packages to Colon, you'll discover countless opportunities for fun and excitement. There's a lot to look forward to, including its lush beauty and laid-back lifestyle. If your trip to Colon includes a little sightseeing, don't miss much-loved attractions like Colon 2000, Monument to Christopher Columbus and Juventud Park. Your Colon vacation is clicks away. Explore hotels, airfares and more on Expedia for a trip that's tailored to suit your travel style.
The Latest Colon vacation packages
Price found within the past 48 hours. Click for updated prices.
Hotel Finca Lerida
Save 100% on your flight
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
8.8/10 Excellent! (180 reviews)
The property is beautifully located on a coffee farm. The rooms are nice and bright. The restaurant is beautiful with outdoor seating with views of the mountain tops. The weather is prefect and you do not need an air conditioner. The staff were wonderful especially Luis.
Reviewed on Aug 8, 2025
Where to stay in Colon
Find the best Colon areas and neighborhoods for the activities you enjoy most. Learn more about Colon
Cristobal
Travelers enjoy Cristobal for its churches and seaside views. Consider checking out Limon Bay while you're in the area.
Discover the most popular places to visit in Colon
Gamboa Rainforest Resort
4/5(299 reviews)
Explore the great outdoors at Gamboa Rainforest Resort, a lovely green space in Gamboa. While you're here, you can savor the top-notch restaurants.
Fort San Lorenzo
4/5(5 reviews)
You can learn about the history of Colon with a stop at Fort San Lorenzo. Stroll along this relaxing area's lakeside, or simply enjoy its restaurants.
Colon 2000
3.5/5(10 reviews)
During your visit to Colon, you can search for that perfect souvenir at Colon 2000. Stroll along this relaxing area's lakeside, or simply enjoy its restaurants.
What to do in Colon
Panama Canal Monkey & Wildlife Boat Safari
$70
per adult
100% of travellers recommend
Panama City: Guided Jungle Adventure with Gatun Lake Cruise
$89
per adult
100% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Colon Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $127 total per night from Aug 25 to Aug 26
$127 total
Aug 25 - Aug 26
Total includes taxes and fees
9/10 Wonderful! (4,148 reviews)
"The hotel is very clean, courteous staff and the location is central."
Reviewed on Aug 14, 2025
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $197 total per night from Sep 16 to Sep 17
$197 total
Sep 16 - Sep 17
Total includes taxes and fees
7.2/10 Good! (1,012 reviews)
Grandbaby’s 1st Family Vacay
"Loved to Italian n French food. Bed were very comfortable but pillows were too thick and uncomfortable. Didn’t get the Internet information to connect to. I got a taxi at the airport for my whole family cause it was cheaper than the resorts transportation."
Reviewed on Aug 14, 2025
Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $111 total per night from Aug 18 to Aug 19
$111 total
Aug 18 - Aug 19
Total includes taxes and fees
9/10 Wonderful! (412 reviews)
"Nice hotel, lively lots of tourists/ music movement. convenient 24/7 coffee shop. walking distance from other restaurants/shops and night life"
Reviewed on Aug 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Hotels near Colon Free Zone
- Hotels near Colon Atlantic Passenger Station
- Hotels near Limon Bay
- Hotels near Enrique Adolfo Jimenez
- Beach Hotels in Fort Sherman
- Fort Sherman Hotels
- Hotels near Galeta Island Marine Education Center
- Cativa Hotels
- Lodges in Cativa
- Hotels near Gatun Locks
- Hotels near Canal Expansion Observation Center
- Sabanitas Hotels
- Flights from Enrique Adolfo Jimenez
- Flights from Panama City (PTY) to Colon (ONX)
- Flights from Miami (MIA) to Colon (ONX)
- Flights from San José (SJO) to Colon (ONX)
- Flights from Los Angeles (LAX) to Colon (ONX)
- Flights from New York (JFK) to Colon (ONX)
- Flights from Manila (MNL) to Colon (ONX)
- Flights from Houston (IAH) to Colon (ONX)
- Flights from Chicago (ORD) to Colon (ONX)
- Flights from San Francisco (SFO) to Colon (ONX)
- Flights to Enrique Adolfo Jimenez
- Flights from Denver (DEN) to Colon (ONX)
- Flights from Dallas (DFW) to Colon (ONX)
- Flights from Atlanta (ATL) to Colon (ONX)
- Flights from Tampa (TPA) to Colon (ONX)
- Flights from Seattle (SEA) to Colon (ONX)
- Flights from Fort Lauderdale (FLL) to Colon (ONX)
- Flights from Boston (BOS) to Colon (ONX)
- Flights from Las Vegas (LAS) to Colon (ONX)
- Flights from Philadelphia (PHL) to Colon (ONX)
- Flights from Phoenix (PHX) to Colon (ONX)
- Flights from Washington (IAD) to Colon (ONX)
- Flights from Baltimore (BWI) to Colon (ONX)
- Flights from Port of Spain (POS) to Colon (ONX)
- Flights from Minneapolis (MSP) to Colon (ONX)
- Flights from Mexico City (MEX) to Colon (ONX)
- Flights from Cartagena (CTG) to Colon (ONX)
- Flights from Balboa (BLB) to Colon (ONX)
- Flights from Tel Aviv (TLV) to Colon (ONX)
- Flights from Bocas del Toro (BOC) to Colon (ONX)
- Flights from Hartford (BDL) to Colon (ONX)
- Flights from Lima (LIM) to Colon (ONX)
- Flights from San Juan (SJU) to Colon (ONX)
- Flights from Oranjestad (AUA) to Colon (ONX)
- Flights from Cancun (CUN) to Colon (ONX)
- Flights from Bogotá (BOG) to Colon (ONX)
- Flights from Winnipeg (YWG) to Colon (ONX)
- Flights from Panama City (PAC) to Colon (ONX)
- Flights from Salt Lake City (SLC) to Colon (ONX)
- Flights from Quito (UIO) to Colon (ONX)
- Flights from Mumbai (BOM) to Colon (ONX)
- Flights from Geneva (GVA) to Colon (ONX)
- Flights from Knoxville (TYS) to Colon (ONX)
- Flights from Munich (MUC) to Colon (ONX)
- Flights from Providence (PVD) to Colon (ONX)
- Flights from Frankfurt (FRA) to Colon (ONX)
- Flights from London (LON) to Colon (ONX)
- Flights from San Salvador (SAL) to Colon (ONX)
- Flights from Guatemala City (GUA) to Colon (ONX)
- Flights from Punta Cana (PUJ) to Colon (ONX)
- Flights from Toronto (YYZ) to Colon (ONX)
- Flights from Buenos Aires (AEP) to Colon (ONX)
- Flights from Buenos Aires (EZE) to Colon (ONX)
- Flights from New York (NYC) to Colon (ONX)
- Flights from George Town (GCM) to Colon (ONX)
- Flights from Madrid (MAD) to Colon (ONX)
- Flights from Copenhagen (CPH) to Colon (ONX)
- Flights from Düsseldorf (DUS) to Colon (ONX)
- Flights from Oslo (OSL) to Colon (ONX)
- Flights from Guayaquil (GYE) to Colon (ONX)
- Flights from Barcelona (BCN) to Colon (ONX)
- Flights from Brussels (BRU) to Colon (ONX)
- Flights from Vitoria (VIX) to Colon (ONX)
- Flights from Warsaw (WAW) to Colon (ONX)
- Flights from Guadalajara (GDL) to Colon (ONX)
- Flights from Istanbul (IST) to Colon (ONX)
- Flights from Manchester (MAN) to Colon (ONX)
- Flights from Sarasota (SRQ) to Colon (ONX)
- Flights from Monterrey (MTY) to Colon (ONX)
- Flights from Stockholm (ARN) to Colon (ONX)
- Flights from Fort Sherman
- Flights to Cativa
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.