A river with a bridge, a town, and a forested hillside.

Find 5 Star Hotels in Hannibal, MO from $195

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Oct 25 - Oct 26
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Oct 26 - Oct 27
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Oct 30 - Nov 1
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Hannibal.
Lighthouse Inn & Suites

Lighthouse Inn & Suites

612 Mark Twain Ave Hannibal MO
$169 nightly
$195 total
Oct 26 - Oct 27
Total with taxes and fees
8.8/10 Excellent! (47 reviews)
Lighthouse Inn & Suites
Garth Woodside Mansion B&B

Garth Woodside Mansion B&B

11069 New London Gravel Rd Hannibal MO
Get rates
9.6/10 Exceptional! (21 reviews)
Garth Woodside Mansion B&B
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hannibal and related destinations

Mark Twain's boyhood home invites you to step into the world that inspired Tom Sawyer and Huckleberry Finn. Explore limestone caves, take a riverboat cruise, or hike to Lover's Leap for spectacular Mississippi River views when morning fog lifts.

See all hotels in Hannibal
A river with a bridge, a town with buildings, and autumn-colored trees.

Top Hannibal Hotel Reviews

Find out more about Hannibal

Ready for an incredible adventure? Add an extra layer of enjoyment on your next trip to Hannibal by treating yourself to the best of the best when it comes to accommodation. It's an ideal fusion. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Hannibal so popular in the last year. There's no reason to delay a getaway to Hannibal any longer. Furthermore, you'll find that these hotels are kept in fantastic condition and provide a fine place to lay your head at night. Reserve one of our 5-star hotels in Hannibal and indulge in the finer things in life for a while. What are you waiting for?

Book the Best Hannibal 5-Star Hotels

Don't be afraid to live the high life while you're on vacation. High-end restaurants, excellent customer care, and deeply relaxing spa offerings are all on offer. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling like a million bucks? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Want to see for yourself? Then explore the 172 reviews various guests have left on Expedia and get to know these places.

Yearning for experiences outside your hotel room? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Hannibal are the perfect place to relax after a busy day.

Your Getaway Starts Today

The results are in, and Hannibal 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Your great getaway is just a mouse-click away -- Expedia can help you land a great deal on accommodation. Select one of our Hannibal 5-star hotels today and dive into in total tranquility tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Hannibal?
The amount you pay for a 5-star hotel in Hannibal can vary based on when you decide to travel and how long you plan to be away, among other factors. Take advantage of our price per night filter and other search tools to land the best deal on a high-end getaway.
  • Search for the lowest price per night from $195
What makes a hotel 5 stars in Hannibal?
In Hannibal, a hotel needs to provide a certain level of upscale features to earn a 5-star rating. These may include on-site gyms, spas and saunas, gourmet restaurants, premium bedding, luxury toiletries and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer additional touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Hannibal?
Expedia's filter tool is the quickest way to narrow down what you want. Select "All inclusive" and "5-star" to see the most luxurious resorts in Hannibal where your meals, lodging, activities and entertainment are included in the price. At these stays, your vacation is pure relaxation and indulgence from the moment you pull up to the entrance.

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