Title: Top Independent in Clarksdale, MS - Expedia.com [Clarksdale Travel Guide](https://expedia.com/Clarksdale.dx6640)[Hotels in Clarksdale](https://expedia.com/Clarksdale-Hotels.d6640.Travel-Guide-Hotels)[Vacation Rentals in Clarksdale](https://expedia.com/Clarksdale-Vacation-Rentals.d6640.Travel-Guide-VacationRentals)[Flights to Clarksdale](https://expedia.com/Cheap-Flights-To-Clarksdale.d6640.Travel-Guide-Flights)[Car Rentals in Clarksdale](https://expedia.com/Car-Rentals-In-Clarksdale.d6640.Car-Rental-Guide)[Clarksdale Vacation Packages](https://expedia.com/Clarksdale.d6640.Destination-Travel-Guides) ![The home of the Delta Blues museum, the Crossroads, Ground Zero Blues club owned by Morgan Freeman and Reds blues club. Several blues festivals in the city. Great authentic blues can be found here. ](https://images.trvl-media.com/place/6640/7baf9be0-ae17-4021-8d1e-fa3526070c6e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Andersen ![](https://images.trvl-media.com/place/6640/7baf9be0-ae17-4021-8d1e-fa3526070c6e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=6640&startDate=2026-03-11&endDate=2026-03-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 12 - Mar 13](https://www.expedia.com/Hotel-Search?regionId=6640&startDate=2026-03-12&endDate=2026-03-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6640&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6640&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels-Independent.0-0-d6640--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FClarksdale-Hotels-Independent.0-0-d6640--bIndependent.Travel-Guide-Filter-Hotels) ## Top Clarksdale Hotel Reviews ![Americas Best Value Inn & Suites Clarksdale](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8_y.jpg) ### Americas Best Value Inn & Suites Clarksdale 10/10 Excellent "Friendly!" [](https://expedia.com/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Travelers Hotel](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/d859aa54_y.jpg) ### Travelers Hotel 10/10 Excellent "Good location and cool vibes" [](https://expedia.com/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Only a mile from historic downtown Clarksdale!](https://images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/ecc9aaad_y.jpg) ### Only a mile from historic downtown Clarksdale! 10/10 Excellent "No dip in the pool, but the stay was excellent. Very quiet, peaceful, and the space was big for two people. Extra room to roam around. Good recommendations for restaurants and sites to see. It was small town relaxation. Thank you John!" [](https://expedia.com/Clarksdale-Hotels-Only-A-Mile-From-Historic-Downtown-Clarksdale.h76031053.Hotel-Information) ![Quality Inn Clarksdale](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_y.jpg) ### Quality Inn Clarksdale 2/10 Terrible "Base board in room was rotted, smelled moldy. No hot breakfast, only a faulty waffle machine." [](https://expedia.com/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Auberge Clarksdale Blues Hostel](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/e0dd2ca5_y.jpg) ### Auberge Clarksdale Blues Hostel 10/10 Excellent "Lots of onstreet parking was available right by the entrance. The place was clean and very quiet. My husband missed having a tv in the room but it was so roomy and pretty. The shared bathroom still felt private and secure. " [](https://expedia.com/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) ![Cotton House, Cleveland, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/36000000/35040000/35030700/35030665/e1a18f2c_y.jpg) ### Cotton House, Cleveland, a Tribute Portfolio Hotel 10/10 Excellent "The clean rooms and comfortable beds." [](https://expedia.com/Greenville-Hotels-Cotton-House.h35030665.Hotel-Information) ![Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale](https://images.trvl-media.com/lodging/114000000/113250000/113243700/113243634/a2e280de_y.jpg) ### Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale 10/10 Excellent "This house was wonderfully clean and well stocked with necessities. Enjoyed our stay very much and would definitely recommend!" [](https://expedia.com/Clarksdale-Hotels-Casa-DAmore-Adorable-Home-Less-Than-12-Mile-From-Downtown-Clarksdale.h113243634.Hotel-Information) ![Cottage on riverbank one mile from Clarksdale in gated community](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/w1024h572x0y55-ec3b8f43_y.jpg) ### Cottage on riverbank one mile from Clarksdale in gated community 10/10 Excellent "The property was wonderful. The beds are absolutely the most comfortable ever, as was the sofa. Very quiet and peaceful. Just what we were looking for." [](https://expedia.com/Clarksdale-Hotels-Cottage-On-The-Sunflower-River.h78995934.Hotel-Information) ![Sunset Log Cabin](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/c2e6d1f4_y.jpg) ### Sunset Log Cabin 10/10 Excellent "A true cabin experience but feels comfortable like home. It is close to the road but I was able to tune out the car noises. The view of sunset is amazing even in the winter time with the already harvested cotton field. All the necessary accessories are provided and very close to town. I’d suggest staying here. " [](https://expedia.com/Clarksdale-Hotels-Sunset-Log-Cabin.h96758575.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Hotels near New Roxy ](https://www.expedia.com/New-Roxy-Hotels.0-l553248621561877044-0.Travel-Guide-Filter-Hotels) - [Hotels near The Holy Moly Theatre ](https://www.expedia.com/The-Holy-Moly-Theatre-Hotels.0-l553248621586301798-0.Travel-Guide-Filter-Hotels) - [Hotels near Delta Blues Museum ](https://www.expedia.com/Delta-Blues-Museum-Hotels.0-l6263361-0.Travel-Guide-Filter-Hotels) - [Hotels near Red's Lounge ](https://www.expedia.com/Reds-Lounge-Hotels.0-l553248621532647956-0.Travel-Guide-Filter-Hotels) - [Hotels near Quapaw Canoe Company ](https://www.expedia.com/Quapaw-Canoe-Company-Hotels.0-l553248621586103760-0.Travel-Guide-Filter-Hotels) - [Hotels near Rock and Blues Museum ](https://www.expedia.com/Rock-And-Blues-Museum-Hotels.0-l6263364-0.Travel-Guide-Filter-Hotels) - [Hotels near Hambone Art Gallery ](https://www.expedia.com/Hambone-Art-Gallery-Hotels.0-l553248621561877046-0.Travel-Guide-Filter-Hotels) - 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