Santa Ana Vacations from $666
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
The Latest Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B
Save 100% on your flight
Price was $1,165, price is now $666 per person
$666
per person
May 4 - May 11
found 11 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.
Reviewed on Jan 22, 2026
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
$69 nightly
The price is $76 total per night from Mar 30 to Mar 31
$76 total
Mar 30 - Mar 31
Total with taxes and fees
9.2/10 Wonderful! (73 reviews)
The room was spotless and the decor was beautiful. The location was very convenient and the staff was friendly, in particular Marciello. The only downsides were that there was no hot water in the shower and the air conditioning vented onto the deck, making it really hot to sit on the deck.
Reviewed on Feb 22, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $156 total per night from Mar 8 to Mar 9
$156 total
Mar 8 - Mar 9
Total with taxes and fees
9/10 Wonderful! (5,038 reviews)
Breakfast was the best, room clean
Reviewed on Mar 1, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $119 total per night from Mar 23 to Mar 24
$119 total
Mar 23 - Mar 24
Total with taxes and fees
7.8/10 Good! (1,005 reviews)
The room was very spacious but was clearly neglected. Very outdated and not clean. The tub was falling apart, the furniture is very worn down. The AC didn't work properly
Reviewed on Mar 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Amador Causeway
You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.
Things to do
Boat tour in the Panama Canal to Monkeys and sloths islands
$74
per adult
100% of travellers recommend
Panama City: Poin Full Package Experience
$155
per adult
98% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Barrio Chino
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- Hotels near Amador Theater
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- Hotels near Casco Viejo
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- Hotels near Palacio de las Garzas
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Independence Square
- Hotels near Museum of History Panama
- Hotels near Ancon Hill
- Hotels near El Chorrillo
- Hotels near Bolivar Square
- Hotels near Palacio Bolivar
- Hotels near National Theater
- Hotels near Club de Clases y Tropas
- Hotels near Paseo de Las Bovedas
- Hotels near National Institute of Culture
- Hotels near Plaza de Francia
- Hostels in Estación Lotería
- Hotels near Estación Lotería
- Apartments in Estación Lotería
- Condo Rentals in Estación Lotería
- Vacation Homes in Estación Lotería
- Visit Barrio Chino
- Avenida Central
- Amador Theater
- Museum of Contemporary Art Panama
- Mi Pueblito
- Iglesia de la Merced
- Casco Viejo Vacations
- Palacio de las Garzas
- Afro Antillean Museum
- Visit Casco Viejo
- Metropolitan Cathedral of Panama
- Independence Square
- Museum of History Panama
- Interoceanic Canal Museum
- Flag of Cerro Ancón
- Ancon Hill
- Bolivar Square
- Palacio Bolivar
- National Theater
- Visit El Chorrillo
- Club de Clases y Tropas
- Anita Villalaz Theater
- Paseo de Las Bovedas
- National Institute of Culture
- Museum of Natural Science
- Maracana Stadium
- Cinta Costera
- Visit Curundu
- Car rentals near Casco Viejo
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- Suv Car Rentals in Casco Viejo
- Europcar Rental Cars in Casco Viejo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.