Santa Ana Vacations from $723
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
The Latest Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,029, price is now $723 per person
$723
per person
Mar 20 - Mar 25
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (4,515 reviews)
Excellent in all aspects. Room entertainment could be substantially improved by providing TV streaming services (NETFLIX, YOUTUBE, etc.
Reviewed on Jan 13, 2026
Mahogany Suites
Price was $1,666, price is now $780 per person
$780
per person
Apr 4 - Apr 11
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
10/10 Exceptional! (1 review)
Room was spotless, front gate staff was really nice, loved the tiny gym on the main floor.
Reviewed on Dec 21, 2025
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,241, price is now $1,264 per person
$1,264
per person
Apr 4 - Apr 11
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
Breakfast and live music was excellent.
Reviewed on Jan 7, 2026
Villa Botero By Casa Mojito B&B
Price was $1,178, price is now $821 per person
$821
per person
Apr 2 - Apr 7
found 3 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.
Reviewed on Apr 18, 2025
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
$83 nightly
The price is $91 total per night from Jan 15 to Jan 16
$91 total
Jan 15 - Jan 16
Total with taxes and fees
9/10 Wonderful! (61 reviews)
Nice roomy place !
Reviewed on Dec 27, 2025
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $127 total per night from Feb 4 to Feb 5
$127 total
Feb 4 - Feb 5
Total with taxes and fees
9/10 Wonderful! (4,823 reviews)
The bed wasn’t comfortable and the windows were always blurry due to the humidity. Couldn’t see the city like I wanted to.
Reviewed on Jan 12, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Jan 26 to Jan 27
$121 total
Jan 26 - Jan 27
Total with taxes and fees
8.4/10 Very Good! (2,397 reviews)
Close to airport with free shuttle. Decent pool. Zero soundproofing and housekeeping worked through the night so you will need plugs if a light sleeper.
Reviewed on Jan 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
4.5/5(634 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Cinta Costera
4.5/5(456 reviews)
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
4/5(554 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Things to do
Boat tour in the Panama Canal to Monkeys and sloths islands
$74
per adult
100% of travellers recommend
Panama City: Poin Full Package Experience
$155
per adult
98% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Barrio Chino
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- Hotels near Casco Viejo
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- Hotels with a View in Casco Viejo
- Hotels with an Outdoor Pool in Casco Viejo
- Hotels near Palacio de las Garzas
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Independence Square
- Hotels near Museum of History Panama
- Hotels near Ancon Hill
- Hotels near El Chorrillo
- Hotels near Bolivar Square
- Hotels near Palacio Bolivar
- Hotels near National Theater
- Hotels near Club de Clases y Tropas
- Hotels near Paseo de Las Bovedas
- Hotels near National Institute of Culture
- Hotels near Plaza de Francia
- Hostels in Estación Lotería
- Hotels near Estación Lotería
- Apartments in Estación Lotería
- Condo Rentals in Estación Loter ía
- Vacation Homes in Estación Lotería
- Visit Barrio Chino
- Avenida Central
- Amador Theater
- Museum of Contemporary Art Panama
- Mi Pueblito
- Iglesia de la Merced
- Casco Viejo Vacations
- Palacio de las Garzas
- Afro Antillean Museum
- Visit Casco Viejo
- Metropolitan Cathedral of Panama
- Independence Square
- Museum of History Panama
- Interoceanic Canal Museum
- Flag of Cerro Ancón
- Ancon Hill
- Bolivar Square
- Palacio Bolivar
- National Theater
- Visit El Chorrillo
- Club de Clases y Tropas
- Anita Villalaz Theater
- Paseo de Las Bovedas
- National Institute of Culture
- Museum of Natural Science
- Maracana Stadium
- Cinta Costera
- Visit Curundu
- Car rentals near Casco Viejo
- Thrifty Car Rental Rental Cars in Casco Viejo
- Hertz Rental Cars in Casco Viejo
- First Car Rental Rental Cars in Casco Viejo
- Van Car Rentals in Casco Viejo
- Alamo Rent A Car Rental Cars in Casco Viejo
- Midsize Car Rentals in Casco Viejo
- SUV Car Rentals in Casco Viejo
- Europcar Rental Cars in Casco Viejo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.