Santa Ana Vacations from $723

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Mahogany Suites
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá
Villa Botero By Casa Mojito B&B

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
$83 nightly
The price is $91 total per night from Jan 15 to Jan 16
$91 total
Jan 15 - Jan 16
Total with taxes and fees
9/10 Wonderful! (61 reviews)
Nice roomy place !

Reviewed on Dec 27, 2025

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $127 total per night from Feb 4 to Feb 5
$127 total
Feb 4 - Feb 5
Total with taxes and fees
9/10 Wonderful! (4,823 reviews)
The bed wasn’t comfortable and the windows were always blurry due to the humidity. Couldn’t see the city like I wanted to.

Reviewed on Jan 12, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Jan 26 to Jan 27
$121 total
Jan 26 - Jan 27
Total with taxes and fees
8.4/10 Very Good! (2,397 reviews)
Close to airport with free shuttle. Decent pool. Zero soundproofing and housekeeping worked through the night so you will need plugs if a light sleeper.

Reviewed on Jan 11, 2026

Crowne Plaza Panama Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Ana

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.