Santa Ana Vacations from $827
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
The Latest Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,739, price is now $1,791 per person
$1,791
per person
Jul 13 - Jul 20
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Excelente localización personal del hotel muy bueno. La crítica.: hotel no te tiene los útiles básicos como crema para la piel, gorro de baño. Cepillo dental etc. Hay q estar en la recepción para recordar y solicitarlo
Reviewed on May 4, 2026
Hotel Riu Plaza Panama
Bella Vista
Price was $1,454, price is now $958 per person
$958
per person
Jun 20 - Jun 27
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,374 reviews)
There’s no extractor fan in the washroom and the toilet division is too small, I kept hitting myself on the toilet paper holder
Reviewed on May 8, 2026
Megapolis Hotel Panamá
San Francisco
Save 100% on your flight
Price was $1,753, price is now $1,166 per person
$1,166
per person
Jun 20 - Jun 27
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,524 reviews)
The spa was amazing so relaxing. The breakfast buffet had an assortment of things to eat but it’s better to get there in the am when the food is fresh. Great room with an amazing view! The kid pool was very dirty though I’m talking about bugs and this whitish film. I hope they also have more amenities such as the club and kids area open up. Seems like still recovering from covid. But overall I would stay again.
Reviewed on May 8, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
Price was $1,649, price is now $1,204 per person
$1,204
per person
Jun 20 - Jun 27
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.6/10 Exceptional! (688 reviews)
This is the definition of a 5 start hotel.
We went to celebrate my husbands birthday because he's an avid golfer. It was easy to book tee times and the service was impeccable.
The course was wel maintained and even saw a crocodile.
The hotel itself went above and beyond because our room wasn't ready at time of arrival.
Reviewed on Apr 5, 2026
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
4.5/5(179 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
$111 nightly
The price is $122 total per night from May 9 to May 10
$122 total
May 9 - May 10
Total with taxes and fees
9/10 Wonderful! (93 reviews)
The building is great, the apartment was perfect, the staff superbe, and they take care of the building, guests and security. There is a supermarket across the street which makes your life so much easier. The issue, as others have mentioned, is that the building is at the limit of the safe area in ...
Reviewed on Apr 29, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 26 to May 27
$151 total
May 26 - May 27
Total with taxes and fees
9/10 Wonderful! (5,406 reviews)
There’s no extractor fan in the washroom and the toilet division is too small, I kept hitting myself on the toilet paper holder
Reviewed on May 8, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from May 17 to May 18
$146 total
May 17 - May 18
Total with taxes and fees
8.6/10 Excellent! (2,523 reviews)
Helpful staff, clean
Reviewed on May 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
4.5/5(643 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Avenida Balboa
4/5(562 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Amador Causeway
4.5/5(767 reviews)
You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.
Things to do
Panama City: POIN Swing Experience
$32
per adult
100% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
$74
per adult
100% of travellers recommend
Panama City: Poin Full Package Experience
$155
per adult
98% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Barrio Chino
- Hotels near Avenida Central
- Hotels near Amador Theater
- Hotels near Danilo Perez Foundation
- Hotels near Iglesia de la Merced
- Hotels near Casco Viejo
- Luxury Hotels in Casco Viejo
- 5 Star Hotels in Casco Viejo
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- Hotels near San Felipe
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- Hotels with a View in Casco Viejo
- Hotels with an Outdoor Pool in Casco Viejo
- Hotels near Palacio de las Garzas
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Independence Square
- Hotels near Museum of History Panama
- Hotels near Ancon Hill
- Hotels near El Chorrillo
- Hotels near Bolivar Square
- Hotels near Palacio Bolivar
- Hotels near National Theater
- Hotels near Club de Clases y Tropas
- Hotels near Paseo de Las Bovedas
- Hotels near National Institute of Culture
- Hotels near Plaza de Francia
- Hostels in Estación Lotería
- Hotels near Estación Lotería
- Apartments in Estación Lotería
- Condo Rentals in Estación Lotería
- Vacation Homes in Estación Lotería
- Visit Barrio Chino
- Avenida Central
- Amador Theater
- Museum of Contemporary Art Panama
- Mi Pueblito
- Iglesia de la Merced
- Casco Viejo Vacations
- Palacio de las Garzas
- Afro Antillean Museum
- Visit Casco Viejo
- Metropolitan Cathedral of Panama
- Independence Square
- Museum of History Panama
- Interoceanic Canal Museum
- Flag of Cerro Ancón
- Ancon Hill
- Bolivar Square
- Palacio Bolivar
- National Theater
- Visit El Chorrillo
- Club de Clases y Tropas
- Anita Villalaz Theater
- Paseo de Las Bovedas
- National Institute of Culture
- Museum of Natural Science
- Maracana Stadium
- Cinta Costera
- Visit Curundu
- Car rentals near Casco Viejo
- Thrifty Car Rental Rental Cars in Casco Viejo
- Hertz Rental Cars in Casco Viejo
- First Car Rental Rental Cars in Casco Viejo
- Van Car Rentals in Casco Viejo
- Alamo Rent A Car Rental Cars in Casco Viejo
- Midsize Car Rentals in Casco Viejo
- Suv Car Rentals in Casco Viejo
- Europcar Rental Cars in Casco Viejo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.