Santa Ana Vacations from $632

Book a Hotel + Flight or Car together to unlock savings

Photo by Isa
  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel
Central Hotel Panama Casco Viejo
Hotel Riu Plaza Panama
The Westin Panama
Mahogany Suites

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
$76 nightly
The price is $83 total per night from Nov 19 to Nov 20
$83 total
Nov 19 - Nov 20
Total with taxes and fees
9.2/10 Wonderful! (50 reviews)
Room was clean large and great to have kitchen and laundry in the unit. The pool is small and not really a lounging area. Overall it was super loud, dogs barking, alarms going off and immediate area a little sketch

Reviewed on Oct 27, 2025

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Nov 23 to Nov 24
$131 total
Nov 23 - Nov 24
Total with taxes and fees
9/10 Wonderful! (4,500 reviews)
Great breakfast, big rooms and view from them

Reviewed on Nov 13, 2025

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Nov 26 to Nov 27
$121 total
Nov 26 - Nov 27
Total with taxes and fees
8.4/10 Very Good! (2,265 reviews)
The hotel room had a a/c leak and all they did was wipe it up. TV had no English channels that is unless maintenance did not know how to change it . Food prices were high

Reviewed on Nov 12, 2025

Crowne Plaza Panama Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Ana

Things to do

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.