Santa Ana Vacations from $453
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
The Latest Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
per person
Oct 15 - Oct 22
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (965 reviews)
I like the breakfast style and everything was near by the hotel. I didn’t like the early morning noise. It was just a little bit noisy. Not a big deal.
Reviewed on Aug 14, 2025
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste, Panama City, Provincia de Panamá
$71 nightly
The price is $79 total per night from Sep 14 to Sep 15
$79 total
Sep 14 - Sep 15
Total includes taxes and fees
9.2/10 Wonderful! (44 reviews)
"Very helpful and offered great suggestions. Cant wait to return!"
Reviewed on Jul 12, 2025
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $127 total per night from Aug 25 to Aug 26
$127 total
Aug 25 - Aug 26
Total includes taxes and fees
9/10 Wonderful! (4,154 reviews)
Perfect spot
"Great hotel. Great location. Great staff! I was disappointed that the pool closed for maintenance two days before my arrival."
Reviewed on Aug 11, 2025
Sheraton Grand Panama
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from Aug 31 to Sep 1
$139 total
Aug 31 - Sep 1
Total includes taxes and fees
8.4/10 Very Good! (925 reviews)
"El hotel es super lindo y el desayuno es muy bueno. La atención también excelente."
Reviewed on Aug 6, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Cinta Costera
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Things to do
Day Tour in San Blas Islands All Included Visiting 4 Islands
$149
per adult
94% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
$32
per adult
100% of travellers recommend
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Hotels near Barrio Chino
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- Hotels near Casco Viejo
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- Hotels with an Outdoor Pool in Casco Viejo
- Hotels near Palacio de las Garzas
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Independence Square
- Hotels near Museum of History Panama
- Hotels near Ancon Hill
- Hotels near El Chorrillo
- Hotels near Bolivar Square
- Hotels near Palacio Bolivar
- Hotels near National Theater
- Hotels near Club de Clases y Tropas
- Hotels near Paseo de Las Bovedas
- Hotels near National Institute of Culture
- Hotels near Plaza de Francia
- Hostels in Estación Lotería
- Hotels near Estación Lotería
- Apartments in Estación Lotería
- Condo Rentals in Estación Lotería
- Vacation Homes in Estación Lotería
- Visit Barrio Chino
- Avenida Central
- Amador Theater
- Museum of Contemporary Art Panama
- Mi Pueblito
- Iglesia de la Merced
- Casco Viejo Vacations
- Palacio de las Garzas
- Afro Antillean Museum
- Visit Casco Viejo
- Metropolitan Cathedral of Panama
- Independence Square
- Museum of History Panama
- Interoceanic Canal Museum
- Flag of Cerro Ancón
- Ancon Hill
- Bolivar Square
- Palacio Bolivar
- National Theater
- Visit El Chorrillo
- Club de Clases y Tropas
- Anita Villalaz Theater
- Paseo de Las Bovedas
- National Institute of Culture
- Museum of Natural Science
- Maracana Stadium
- Cinta Costera
- Visit Curundu
- Car rentals near Casco Viejo
- Thrifty Car Rental Rental Cars in Casco Viejo
- Hertz Rental Cars in Casco Viejo
- First Car Rental Rental Cars in Casco Viejo
- Van Car Rentals in Casco Viejo
- Alamo Rent A Car Rental Cars in Casco Viejo
- Midsize Car Rentals in Casco Viejo
- SUV Car Rentals in Casco Viejo
- Europcar Rental Cars in Casco Viejo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.