Santa Ana Vacations from $632
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Your Santa Ana Vacation
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.
The Latest Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel
Amador
Price was $968, price is now $632 per person
$632
per person
Jan 10 - Jan 17
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
16.4/10 Exceptional! (166 reviews)
The hotel could use some maintenance, but overall, my stay was pleasant. The staff were all friendly and welcoming, which made a positive impression. My only real issue was the loud music coming from the building at the end of the hotel block—it played until 3 a.m., which made it difficult to rest. Aside from that, everything was fine. The scenery was lovely and added a nice touch to the experience.
Reviewed on Nov 17, 2025
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,624, price is now $1,316 per person
$1,316
per person
Feb 4 - Feb 11
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
18/10 Exceptional! (1,002 reviews)
Hotel was beautiful, staff was very helpful and accommodating. We had the pool two separate days to ourselves. Breakfadt was very good. Staff was very helpful getting us drivers wherever we wanted to go in the city.
Reviewed on Nov 16, 2025
The Westin Panama
Costa del Este
Save 100% on your flight
Price was $1,651, price is now $1,101 per person
$1,101
per person
Jan 31 - Feb 7
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (297 reviews)
The Business Suite option is well worth it!
Reviewed on Nov 8, 2025
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Santa Ana Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
$76 nightly
The price is $83 total per night from Nov 19 to Nov 20
$83 total
Nov 19 - Nov 20
Total with taxes and fees
9.2/10 Wonderful! (50 reviews)
Room was clean large and great to have kitchen and laundry in the unit. The pool is small and not really a lounging area. Overall it was super loud, dogs barking, alarms going off and immediate area a little sketch
Reviewed on Oct 27, 2025
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Nov 23 to Nov 24
$131 total
Nov 23 - Nov 24
Total with taxes and fees
9/10 Wonderful! (4,500 reviews)
Great breakfast, big rooms and view from them
Reviewed on Nov 13, 2025
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$110 nightly
The price is $121 total per night from Nov 26 to Nov 27
$121 total
Nov 26 - Nov 27
Total with taxes and fees
8.4/10 Very Good! (2,265 reviews)
The hotel room had a a/c leak and all they did was wipe it up. TV had no English channels that is unless maintenance did not know how to change it . Food prices were high
Reviewed on Nov 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Ana
Multiplaza Pacific Mall
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Cinta Costera
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Things to do
Panama City: Poin Full Package Experience
$155
per adult
90% of travellers recommend
Boat tour in the Panama Canal to Monkeys and sloths islands
$74
per adult
90% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Barrio Chino
- Hotels near Avenida Central
- Hotels near Amador Theater
- Hotels near Danilo Perez Foundation
- Hotels near Iglesia de la Merced
- Hotels near Casco Viejo
- Luxury Hotels in Casco Viejo
- 5 Star Hotels in Casco Viejo
- Cheap Hotels in Casco Viejo
- Hotels near San Felipe
- Hotels with Restaurants in Casco Viejo
- Hotel Wedding Venues Hotels in Casco Viejo
- Hotels with a Gym in Casco Viejo
- Hotels with a Pool in Casco Viejo
- Boutique Hotels in Casco Viejo
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- Resorts & Hotels with Spas in Casco Viejo
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- Historic Hotels in Casco Viejo
- Beach Hotels in Casco Viejo
- Gay friendly Hotels in Casco Viejo
- 4 Star Hotels in Casco Viejo
- Hotels with smoking rooms in Casco Viejo
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- Hotels with Free Breakfast in Casco Viejo
- Marriott Hotels & Resorts in Casco Viejo
- Hotels with Bars in Casco Viejo
- Pet-friendly Hotels in Casco Viejo
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- Romantic Hotels in Casco Viejo
- Quiet Resorts & in Casco Viejo
- Hilton Hotels in Casco Viejo
- Ace Hotel in Casco Viejo
- Hotels with Balconies in Casco Viejo
- Winery Hotels in Casco Viejo
- Hotels with Suites in Casco Viejo
- Extended Stay Hotels in Casco Viejo
- Hotels with Air Conditioning in Casco Viejo
- Hotels with Childcare in Casco Viejo
- Hotels with Connecting Rooms in Casco Viejo
- Hotels with a View in Casco Viejo
- Hotels with an Outdoor Pool in Casco Viejo
- Hotels near Palacio de las Garzas
- Hotels near Metropolitan Cathedral of Panama
- Hotels near Independence Square
- Hotels near Museum of History Panama
- Hotels near Ancon Hill
- Hotels near El Chorrillo
- Hotels near Bolivar Square
- Hotels near Palacio Bolivar
- Hotels near National Theater
- Hotels near Club de Clases y Tropas
- Hotels near Paseo de Las Bovedas
- Hotels near National Institute of Culture
- Hotels near Plaza de Francia
- Hostels in Estación Lotería
- Hotels near Estación Lotería
- Apartments in Estación Lotería
- Condo Rentals in Estación Lotería
- Vacation Homes in Estación Lotería
- Visit Barrio Chino
- Avenida Central
- Amador Theater
- Museum of Contemporary Art Panama
- Mi Pueblito
- Iglesia de la Merced
- Casco Viejo Vacations
- Palacio de las Garzas
- Afro Antillean Museum
- Visit Casco Viejo
- Metropolitan Cathedral of Panama
- Independence Square
- Museum of History Panama
- Interoceanic Canal Museum
- Flag of Cerro Ancón
- Ancon Hill
- Bolivar Square
- Palacio Bolivar
- National Theater
- Visit El Chorrillo
- Club de Clases y Tropas
- Anita Villalaz Theater
- Paseo de Las Bovedas
- National Institute of Culture
- Museum of Natural Science
- Maracana Stadium
- Cinta Costera
- Visit Curundu
- Car rentals near Casco Viejo
- Thrifty Car Rental Rental Cars in Casco Viejo
- Hertz Rental Cars in Casco Viejo
- First Car Rental Rental Cars in Casco Viejo
- Van Car Rentals in Casco Viejo
- Alamo Rent A Car Rental Cars in Casco Viejo
- Midsize Car Rentals in Casco Viejo
- SUV Car Rentals in Casco Viejo
- Europcar Rental Cars in Casco Viejo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.