Name: Crowne Plaza Panama Airport by IHG
Price range: $151 total
Rating: 8.6

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Casa Mallet by Wynwood House

Casco Viejo

$848

per person

Sep 11 - Sep 14

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (27 reviews)

In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$941

per person

Aug 19 - Aug 23

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.2/10 Wonderful! (1,008 reviews)

Beautiful hotel with great history! The location in Casco Viejo was perfect for our visit to Panama City and we were easily able to walk or order a car/Uber from there for various trips. We had a family suite, which was a king and full size bed room that worked well for our family of 3. The rooftop pool is small, but lovely and the restaurant near the pool was great with friendly staff. The Central Hotel is a gorgeous place and the staff at the front desk, door and restaurants were all nice and helpful.

Reviewed on Jun 30, 2026

Megapolis Hotel Panamá

San Francisco

$1,045

per person

Aug 1 - Aug 6

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,570 reviews)

The whole staff was extremely helpful.

Reviewed on Jul 1, 2026

Riande Aeropuerto Hotel & Casino

$997

per person

Aug 1 - Aug 6

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

8.4/10 Very Good! (1,813 reviews)

In the bathroom, the shower tiles and glass door had green mold, the headboard had strange white stains, and the curtains were very dusty. The staff was very friendly and provided excellent service. However, I have other complaints regarding the bathroom and room.

Reviewed on Jul 2, 2026

Yoo by Wynwood House

Calidonia

$1,004

per person

Sep 15 - Sep 22

found 16 hours ago

Roundtrip flight included

Port of Spain (POS) to Panama City (PTY)

9.4/10 Exceptional! (6 reviews)

Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

4.5/5(179 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Santa Ana Hotel Deals

Casco View Apartments

C. 16 Oeste Panama City Provincia de Panamá

$116 nightly

$128 total

Jul 13 - Jul 14

Total with taxes and fees

9/10 Wonderful! (100 reviews)

"Great layout with modern convenience for my family, sofa bed was generous and comfortable. Thoughtful kitchen tools made our stay easy."

Reviewed on Jun 20, 2026

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$147 nightly

$162 total

Jul 3 - Jul 4

Total with taxes and fees

9/10 Wonderful! (5,673 reviews)

"The Staff is Bad and if you From United States they Give you Hard time and Extra fees and they Steal item the cleaning Ladys"

Reviewed on Jul 2, 2026

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama

Fully refundable

$137 nightly

$151 total

Jul 31 - Aug 1

Total with taxes and fees

8.6/10 Excellent! (2,613 reviews)

"Good hotel very convenient for 1 night close to the airport."

Reviewed on Jul 2, 2026

See all 1,761 properties in Santa Ana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.