Santa Ana Vacation Packages 2026 from $857

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

Save 100% on your flight

$857

per person

Dec 9 - Dec 16

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,820 reviews)

A one night stay, I would have preferred a room closer to reception.

Reviewed on Oct 2, 2026

Megapolis Hotel Panamá

San Francisco

$985

per person

Dec 9 - Dec 16

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

8.6/10 Excellent! (1,743 reviews)

Overall my stay was a 10/10 would definitely be back!

Reviewed on Oct 2, 2026

Central Hotel Panama Casco Viejo

Casco Viejo

$1,211

per person

Dec 9 - Dec 16

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (1,007 reviews)

This is a great hotel, and the location was perfect. The rooms were nice, and the staff were very friendly. I would highly recommend it.

Reviewed on Oct 1, 2026

Hotel Riu Plaza Panama

Bella Vista

$917

per person

Dec 9 - Dec 16

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (5,977 reviews)

Casa Mallet by Wynwood House

Casco Viejo

Save 100% on your flight

$1,761

per person

Dec 23 - Dec 28

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9.8/10 Exceptional! (30 reviews)

I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

1 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Santa Ana Hotel Deals

Hotel Caracas - Casco Viejo

Plaza De Santa Ana Panama City Provincia di Panama

Fully refundableReserve now, pay when you stay

$40 nightly

$44 total

Oct 5 - Oct 6

Total with taxes and fees

8/10 Very Good! (19 reviews)

"Good location but basic otherwise. Staff not overly helpful on the whole."

Reviewed on Sep 27, 2026

Casco View Life Residences

C. 16 Oeste Panama City Provincia de Panamá

$106 nightly

$117 total

Oct 3 - Oct 4

Total with taxes and fees

9/10 Wonderful! (106 reviews)

"We really enjoyed our stay at Casco View. It was an easy walk into Casca Viejo and centrally located. The host uses a guesty app to provide room details, apartment codes, etc, so it was a really easy and smooth process to get checked in. The room itself was very clean and well appointed. We stayed ..."

Reviewed on Sep 8, 2026

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

$138 nightly

$151 total

Oct 25 - Oct 26

Total with taxes and fees

See all 1,793 properties in Santa Ana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.