Santa Ana
Panama City
Visit Santa Ana
Stay near popular Santa Ana attractions
Things to do
Panama Canal: The Most Complete Wildlife Experience
$48
per adult
98% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
$99
per adult
94% of travellers recommend
From Panama City: San Blas Island Hopping Day Tour
$145
per adult
98% of travellers recommend
All-inclusive catamaran 7.5h Isla Taboga from Panama City
$99
per adult
94% of travellers recommend
Panama: Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
$32
per adult
100% of travellers recommend
Santa Ana Hotel Deals
Hotel Caracas - Casco Viejo
Plaza De Santa Ana Panama City Provincia di Panama
$41 nightly
The price is $46 total per night from Oct 19 to Oct 20
$46 total
Oct 19 - Oct 20
Total with taxes and fees
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...
8/10 Very Good! (20 reviews)
"Good location but basic otherwise. Staff not overly helpful on the whole."
Reviewed on Sep 27, 2026
Casco View Life Residences
C. 16 Oeste Panama City Provincia de Panamá
$111 nightly
The price is $122 total per night from Oct 18 to Oct 19
$122 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
$141 nightly
The price is $156 total per night from Oct 25 to Oct 26
$156 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (6,086 reviews)
"Very nice hotel"
Reviewed on Oct 17, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
$95 nightly
The price is $105 total per night from Nov 8 to Nov 9
$105 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,001 reviews)
"Our room was giant and dated with little furniture and extras. Tea and coffee was a one time deal. We often had to ask for water and towels otherwise they wouldn’t be stocked. The reception was slow to respond and at times did not help with basics. ( Water was lukewarm most days with the exception ..."
Reviewed on Oct 17, 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
$141 nightly
The price is $155 total per night from Nov 3 to Nov 4
$155 total
Nov 3 - Nov 4
Total with taxes and fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (2,767 reviews)
"Clean rooms"
Reviewed on Oct 16, 2026
Megapolis Hotel Panamá
Avenida Balboa Panama City
$133 nightly
The price is $133 total per night from Oct 23 to Oct 24
$133 total
Oct 23 - Oct 24
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (1,791 reviews)
"Gorgeous property, well maintained. More family friendly, we were not able to enjoy the rooftop pool as there were about 20 kids splashing around living their best life. We went to the sports lounge and it was also filled with kids. Not a big deal, service was great. This is a great place for families ..."
Reviewed on Oct 17, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Photo by Fabiola Tile
Open Photo by Fabiola Tile
Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
Santa Ana
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