Santa Ana
Panama City
Visit Santa Ana
Stay near popular Santa Ana attractions
Things to do
Panama Canal: The Most Complete Wildlife Experience
$36
per adult
100% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
$99
per adult
94% of travellers recommend
From Panama City: San Blas Islands Tour with Island Hopping
$145
per adult
98% of travellers recommend
Panama: Monkey and Sloth Jungle Habitat Panama Tour
$60
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
$32
per adult
100% of travellers recommend
Panama City: Poin Full Package Experience
$155
per adult
98% of travellers recommend
Santa Ana Hotel Deals
Hotel Caracas - Casco Viejo
Plaza De Santa Ana Panama City Provincia di Panama
$52 nightly
The price is $57 total per night from Nov 3 to Nov 4
$57 total
Nov 3 - Nov 4
Total with taxes and fees
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...
7.4/10 Good! (26 reviews)
"The room was not like the picture it was outdated and musty, no refrigerator or microwave. I would spend the extra money next time elsewhere"
Reviewed on Oct 27, 2026
Casco View Life Residences
C. 16 Oeste Panama City Provincia de Panamá
$111 nightly
The price is $122 total per night from Nov 3 to Nov 4
$122 total
Nov 3 - Nov 4
Total with taxes and fees
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
9/10 Wonderful! (114 reviews)
"The staff was very friendly and helpful which made our stay very pleasant and enjoyable."
Reviewed on Oct 31, 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
$118 nightly
The price is $130 total per night from Dec 1 to Dec 2
$130 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (6,165 reviews)
"The hotel is very well located, and the breakfast is decent. However, our room had a strong mildew smell and seemed poorly ventilated. The air conditioning appeared to have been left off before our arrival. Although it was turned on as soon as we arrived, the unpleasant smell persisted and kept me ..."
Reviewed on Nov 2, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
$84 nightly
The price is $93 total per night from Nov 6 to Nov 7
$93 total
Nov 6 - Nov 7
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
Megapolis Hotel Panamá
Avenida Balboa Panama City
$129 nightly
The price is $144 total per night from Nov 7 to Nov 8
$144 total
Nov 7 - Nov 8
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$146 nightly
The price is $161 total per night from Nov 26 to Nov 27
$161 total
Nov 26 - Nov 27
Total with taxes and fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Photo by Fabiola Tile
Open Photo by Fabiola Tile
Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
Santa Ana
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