Santa Ana

Panama City

A gazebo with columns, a large tree with hanging roots, and a building in the background.
A waterfront cityscape with numerous boats docked along the shore and a clear sky.

Discover a blend of historical sites, shopping venues, and natural parks that showcase the richness of Santa Ana.

Santa Ana is ideal for family and city travelers looking for a blend of activities and sights. You can explore the Amador Causeway, a notable monument nearby, or visit the Iglesia del Carmen, a nearby church. The modern Bridge of the Americas also offers a unique view. For shopping, El Machetazo Santa Ana serves as a venue, while Avenida Central and Multiplaza Pacific Mall are other nearby shopping centers. If you're interested in nature, consider visiting the nearby Causeway Islands and Soberania National Park, both known for outdoor and family tourism.

You can also explore Santa Ana's nearby neighborhoods, each offering distinct experiences. Calidonia is known for family-friendly attractions such as Avenida Balboa and the National Bank House Museum. Another area, Casco Viejo, features historical sites like the Metropolitan Cathedral of Panama and the National Theater. Marbella is another nearby neighborhood that focuses on city experiences, complementing the offerings of Calidonia and Casco Viejo and providing a rich cultural backdrop for visitors.

The best time to visit Santa Ana largely depends on the rain rather than temperature, as the weather remains warm and fairly constant year-round. Rain is heavier from May to November, which may affect your plans. Demand for accommodations and activities tends to stay steady throughout the year, so you can expect a consistent experience whenever you choose to visit.


Stay near popular Santa Ana attractions

Things to do


Santa Ana Hotel Deals

Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo

3 out of 5
Plaza De Santa Ana Panama City Provincia di Panama
$35 nightly
The price is $38 total per night from Nov 12 to Nov 13
$38 total
Nov 12 - Nov 13
Total with taxes and fees
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...
7.6/10 Good! (31 reviews)
"El lugar es acorde a lo q se paga, esta donde termina el casco viejo y empieza un barrio feo"

Reviewed on Nov 5, 2026

Hotel Caracas - Casco Viejo
Casco View Life Residences

Casco View Life Residences

4 out of 5
C. 16 Oeste Panama City Provincia de Panamá
$100 nightly
The price is $111 total per night from Nov 15 to Nov 16
$111 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
9/10 Wonderful! (114 reviews)
"The staff was very friendly and helpful which made our stay very pleasant and enjoyable."

Reviewed on Oct 31, 2026

Casco View Life Residences
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$132 nightly
The price is $145 total per night from Dec 1 to Dec 2
$145 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
$99 nightly
The price is $109 total per night from Nov 25 to Nov 26
$109 total
Nov 25 - Nov 26
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,018 reviews)
"Muy mala la atención, no fueron amables, no accedieron a mi petición de una habitación en 1 piso por estar con niños pequeños, mala distribución de toallas, papel, etc"

Reviewed on Nov 10, 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
$146 nightly
The price is $161 total per night from Nov 26 to Nov 27
$161 total
Nov 26 - Nov 27
Total with taxes and fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Crowne Plaza Panama Airport by IHG
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
$263 nightly
The price is $263 total per night from Dec 1 to Dec 2
$263 total
Dec 1 - Dec 2
Total with taxes and fees
Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall ...
7.8/10 Good! (1,128 reviews)
"Very nice place to relax. The food was good. The room was clean with a nice view to the ocean and the canal."

Reviewed on Nov 10, 2026

Dreams Playa Bonita Panama - All Inclusive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Learn more about Santa Ana

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.



Santa Ana

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