Plan your trip
Check prices for these dates, December 13 – 14, 2026
The best area to stay in Brookline is near the intersection of Highway 60 and James River Freeway, as this offers the most convenient access to amenities and travel routes.
This area, while primarily residential, provides easy connections to larger neighboring cities. You'll find a few local businesses and dining options along Highway 60, making it a practical base for exploring the wider region.
For travelers who value convenience and easy access to major roadways, this central Brookline location is ideal.
The best time to visit Brookline, Missouri, is during the spring (April to June) and fall (September to October) months.
Spring offers pleasant temperatures and blooming landscapes, making it ideal for outdoor activities like exploring the nearby parks or enjoying a stroll through the local areas. The weather is generally mild, great for those who prefer comfortable conditions without the intense heat of summer.
Fall provides crisp air, colorful foliage, and comfortable temperatures, which are great for experiencing the region's natural beauty. This season is particularly appealing for travelers who enjoy scenic drives and outdoor excursions.
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Brookline.
Prices for hotels in Brookline often vary, but you can find a great deal from $87 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.