Find hotels in Cayuse, OR from $73

The best area to stay in Cayuse is directly within the town center, as it offers the most convenient access to local amenities and the surrounding natural beauty.The town center of Cayuse is a compact and walkable area, characterized by its main street where you'll find local shops, eateries, and community buildings. It's a peaceful spot that serves as a central hub for exploring the Umatilla National Forest and nearby attractions.For solo travelers or couples seeking a quiet retreat with easy access to outdoor activities, the town center is ideal.

The best time to go to Cayuse is during the late spring, from May to June, or in the early fall, from September to October, to enjoy comfortable weather and fewer crowds.During late spring, the weather is pleasantly mild, with average temperatures ranging from the mid-60s to low 70s Fahrenheit. This is an excellent time for outdoor activities like exploring the nearby Umatilla National Forest or visiting local vineyards, as the landscape is lush and green. Travelers looking for a relaxed experience will appreciate the comfortable climate before the peak summer heat arrives.Early fall offers similar comfortable temperatures, usually in the high 60s, and the region's agricultural areas are often in harvest season, providing unique local experiences. The autumn foliage also adds to the scenic beauty, making it a great time for photography and scenic drives.

With Expedia, you earn OneKeyCash™* on eligible Cayuse hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.