O Brien, FL

Travel Guide

A calm river with clear water, surrounded by dense trees and rocky banks.
A clear blue pond surrounded by dense forest.
A calm river surrounded by trees reflecting in the water.
A calm river with trees reflecting the sunlight.
A swampy area with a calm water body surrounded by various trees and vegetation.
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
Book a stay at this beach vacation home in O Brien. Enjoy free WiFi, a beach locale, and a fitness center. Popular attractions Wes Skiles Peacock Springs State ...
10/10 Exceptional! (44 reviews)
"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

Reviewed on Sep 21, 2026

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Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

3 out of 5
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $111 total per night from Oct 12 to Oct 13
$111 total
Oct 12 - Oct 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
$104 nightly
The price is $117 total per night from Nov 8 to Nov 9
$117 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
See all 397 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
Book a stay at this beach vacation home in O Brien. Enjoy free WiFi, a beach locale, and a fitness center. Popular attractions Wes Skiles Peacock Springs State ...
10/10 Exceptional! (44 reviews)
"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

Reviewed on Sep 21, 2026

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ...
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Beautiful cozy cottage fully fenced near town and springs

Beautiful cozy cottage fully fenced near town and springs

High Springs FL
Stay at this cottage in High Springs. Enjoy a garden, laundry facilities, and patios. Popular attractions Catherine Taylor Park and High Springs Library Branch ...
8.8/10 Excellent! (57 reviews)
"Clean room"

Reviewed on Sep 8, 2026

Beautiful cozy cottage fully fenced near town and springs
See all properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

When is the best time to visit O Brien?
The best time to visit O Brien is from June through August, during its warmer season, when it is most popular with travelers. For those looking for fewer crowds and better value, the quieter months of November through January are a good option to consider.
Can I book a refundable hotel in O Brien?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in O Brien by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to O Brien with Expedia?
Expedia makes it easier to plan your O Brien trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in O Brien?
The best choice depends on your travel style. Hotels in O Brien can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my O Brien trip on Expedia?
Once you've booked your O Brien trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my O Brien trip?
Expedia offers customer support before, during, and after your O Brien trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to O Brien?
If it's your first trip to O Brien, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my O Brien hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your O Brien hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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A park with large trees and a grassy area.

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A clear, turquoise pool surrounded by wooden decks and dense forest.

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A white heron standing in shallow water surrounded by green vegetation.

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