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Our top choices for O Brien hotels

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,000 reviews)
"Breakfast was good with lots of choices. We would stay there again."
United States
christina
12 days ago
$104 nightly
The price is $117
Apr 12 - Apr 13
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.6 out of 10, Excellent, (1,087 reviews)
"Staff was nice and friendly."
United States
Roderick
3 days ago
$103 nightly
The price is $115
Apr 12 - Apr 13
Total with taxes and fees
La Quinta Inn & Suite by Wyndham Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,034 reviews)
"Room was clean and well kept. The bed was very comfortable."
United States
Katie
16 days ago
$99 nightly
The price is $111
Apr 12 - Apr 13
Total with taxes and fees
Best Western Plus Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,006 reviews)
"Great spacious room very clean, friendly staff, easy check."
United States
Teresa
November 18th, 2025
$109 nightly
The price is $123
Apr 19 - Apr 20
Total with taxes and fees
Tru by Hilton Lake City

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (777 reviews)
"Impressed, will use again for sure."
United States
james m
January 5th, 2026
$128 nightly
The price is $144
Apr 12 - Apr 13
Total with taxes and fees
Home2 Suites by Hilton Lake City

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
"My stay was relaxing and peaceful."
United States
Kevin
8 days ago
$105 nightly
The price is $118
Apr 19 - Apr 20
Total with taxes and fees
Holiday Inn & Suites Lake City by IHG

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.6 out of 10, Excellent, (28 reviews)
"We had a good family getaway. My family had an awesome outdoor experience."
United States
amy
10 days ago
$43 nightly
The price is $46
Apr 13 - Apr 14
Total with taxes and fees
Suwannee River Rendezvous

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (232 reviews)
"Was able to check in late with a very helpful hostess."
United States
Timothy J
December 14th, 2025
$105 nightly
The price is $119
Apr 19 - Apr 20
Total with taxes and fees
Courtyard By Marriott Lake City

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1,004 reviews)
"The owner manager does a great job with customer service on the afternoon evening."
United States
john
7 days ago
$67 nightly
The price is $76
Apr 12 - Apr 13
Total with taxes and fees
Americas Best Value Inn Lake City

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very Good, (819 reviews)
"Breakfast and pool were fine."
United States
George
11 days ago
$110 nightly
The price is $121
May 10 - May 11
Total with taxes and fees
Holiday Inn Express & Suites Live Oak by IHG

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Our room was ready. The beds were very comfortable."
United States
Mary
28 days ago
$124 nightly
The price is $140
Apr 12 - Apr 13
Total with taxes and fees
Hampton Inn & Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1,004 reviews)
"Clean room and facilities with very friendly staff during our entire stay."
United States
Moriah
March 8th, 2026
$107 nightly
The price is $120
May 10 - May 11
Total with taxes and fees
Comfort Suites Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (221 reviews)
"One of the best breakfasts we've had at a hotel."
United States
Linette
9 days ago
$101 nightly
The price is $114
Apr 19 - Apr 20
Total with taxes and fees
Fairfield Inn & Suites Lake City

Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
2.5 star property
Alachua
7.2 out of 10, Good, (1,002 reviews)
"This is a good place for a short stay."
United States
Mike
14 days ago
$76 nightly
The price is $85
Apr 19 - Apr 20
Total with taxes and fees
Quality Inn Alachua - Gainesville Area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (498 reviews)
"Easy access to I75 and Dunkin."
United States
Nick
24 days ago
$106 nightly
The price is $119
Apr 19 - Apr 20
Total with taxes and fees
Hampton Inn & Suites Alachua I-75

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (429 reviews)
"Good parking at door made it very easy access to our car."
United States
Janice
17 days ago
$95 nightly
The price is $106
May 3 - May 4
Total with taxes and fees
BlueGem Motel

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (656 reviews)
"The staff was excellent with my short notice cancellation."
United States
Susan
4 days ago
$68 nightly
The price is $75
Apr 27 - Apr 28
Total with taxes and fees
Quality Inn White Springs Suwanee

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (603 reviews)
"Room was clean and the air conditioning worked great would recommend."
United States
david
26 days ago
$65 nightly
The price is $73
Apr 12 - Apr 13
Total with taxes and fees
Palms Garden Inn

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (703 reviews)
"Great counters in the bathroom!! Loved the served breakfast and dinner!"
United States
Wendy
3 days ago
$63 nightly
The price is $71
May 10 - May 11
Total with taxes and fees
Super 8 by Wyndham Lake City

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very Good, (1,006 reviews)
"Room is clean and smell good."
United States
Danny
1 day ago
$72 nightly
The price is $81
May 10 - May 11
Total with taxes and fees
Quality Inn Lake City
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

More cheap stays in O Brien

Hotels in O Brien with star-rating

Find out more about O Brien

Top reasons to visit O Brien

  • Outdoor Adventures: O'Brien is perfect for outdoor enthusiasts, offering activities like hiking, fishing, and exploring scenic parks.
  • Scenic Beauty: The area boasts stunning natural landscapes, including local rivers and tranquil nature trails.
  • Community Events: Experience a friendly atmosphere with vibrant community events and local culture.
  • Accommodations for Everyone: O'Brien has a range of welcoming accommodations, from pet-friendly motels to cozy hotels.
  • Family-Friendly Atmosphere: Ideal for families, O'Brien offers a mix of adventure and relaxation for all ages.

Find great hotels near O Brien

Discover a variety of welcoming accommodations in O'Brien, Florida, ideal for every traveler. Whether you’re seeking a pet-friendly motel or a cozy hotel for business travel, you'll find options that provide essential amenities like free Wi-Fi. Enjoy an inclusive atmosphere perfect for LGBTQIA travelers, and explore nearby Branford and Troy Street for additional lodging choices. Your perfect O'Brien getaway awaits.

  • Baymont by Wyndham Lake City I-75: Located 18 miles from O'Brien, Baymont by Wyndham Lake City I-75 offers a budget-friendly stay perfect for families and business travelers alike. This pet-friendly hotel provides a welcoming atmosphere with amenities tailored for children, including complimentary cribs. Guests can enjoy the convenience of bringing their furry friends along, with specific pet policies in place. The hotel fosters a family-oriented environment while ensuring comfort and accessibility for all guests.
  • Americas Best Value Inn Lake City: Just 18 miles from O'Brien, Americas Best Value Inn Lake City boasts a commendable guest rating of 8.6 out of 10. This budget-friendly motel is ideal for pet owners seeking a comfortable getaway. With a focus on affordability and convenience, the hotel permits pets onsite, alongside a waived fee for service animals. Visitors appreciate the warm hospitality and the straightforward amenities that make their stay enjoyable.
  • Comfort Suites Lake City: Situated 18 miles away from O'Brien, Comfort Suites Lake City is a highly rated hotel with an impressive score of 9.6 out of 10. This establishment caters primarily to business travelers, offering spacious suites equipped for productivity and relaxation. Guests can appreciate the well-appointed facilities and a commitment to quality service, ensuring a successful stay for those traveling for work or leisure.

Where to stay near O Brien

O'Brien, Florida, is a hidden gem perfect for outdoor enthusiasts and families alike. With stunning scenery and adventurous activities, you'll find plenty to explore in this charming city. Nearby attractions offer a friendly atmosphere, inviting travelers to enjoy nature trails, local parks, and vibrant community events. Whether you're looking to unwind or embark on an adventure, O'Brien and its surrounding areas promise a memorable vacation experience.

  • Branford: Located a mere 6 miles from O'Brien, Branford is a charming city that attracts visitors year-round, with peak traveler arrivals in April and June to July. This destination is perfect for outdoor enthusiasts and adventure seekers, offering a variety of recreational areas, underwater sports, and breathtaking scenery. You can explore the nearby national state park, meander along the serene river, or partake in exciting adventure activities. Branford's natural beauty and welcoming atmosphere make it a delightful stop for those looking to connect with nature and enjoy thrilling experiences.
  • Mcalpin: Situated 7 miles away from O'Brien, Mcalpin is another appealing city that sees moderate seasonal travel throughout the year, with visitor numbers peaking consistently. It’s an ideal location for those who love the great outdoors, featuring stunning landscapes and an array of adventure activities. Visitors can enjoy recreational areas and partake in underwater sports while discovering the nearby national state park and tranquil river settings. Mcalpin provides a perfect blend of adventure and relaxation, making it a great spot for family outings or solo explorations.
  • Mayo: Located 14 miles from O'Brien, Mayo is a picturesque city that welcomes visitors throughout the year, with peak seasons in March to April and September. Known for its outdoor adventures and scenic views, Mayo offers various recreational activities and underwater sports that thrill adventure seekers. The proximity to a national state park, lush parks, and the scenic river enhances your experience, inviting you to immerse yourself in nature’s splendor. Mayo's small-town charm and vibrant outdoor culture make it a must-visit destination for those looking to escape into nature.

Things to do in O Brien

O'Brien, Florida, is perfect for outdoor enthusiasts seeking adventure and scenic beauty. Popular activities include exploring recreational areas, engaging in underwater sports, and enjoying various adventure activities. It's an ideal destination for fishing enthusiasts and those looking for exciting Florida tours, making it a great spot for an unforgettable vacation filled with exploration and fun.

Shopping

In O'Brien, you can enjoy local shops offering unique souvenirs and gifts. If you're up for a drive, check out the nearby Lake City Mall, where you'll find a variety of retailers, from fashion to home goods, perfect for picking up memorable items from your trip.

Recreation

Experience tranquility at the Suwannee River Retreat, where you can unwind with yoga classes and nature walks along the serene riverbanks. For recreational fun, explore nearby parks for hiking and fishing, or enjoy a peaceful kayak ride on the beautiful waters.

Adventure

In O'Brien, explore the scenic beauty of the nearby Suwannee River, perfect for kayaking and fishing. Experience thrilling airboat rides through the wetlands, offering close encounters with unique wildlife. Don't miss the picturesque trails for hiking and biking, showcasing Florida's lush landscapes and diverse ecosystems.

Nightlife

In O'Brien, Florida, the nightlife is laid-back yet vibrant, featuring local bars and cozy venues. The O'Brien Community Center hosts events, while nearby spots offer live music and friendly gatherings, perfect for unwinding after a day of exploring the area's natural beauty.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for O Brien

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in O Brien are January, August and November, where the prices are slightly lower. This is in comparison to March, May and October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in O Brien is Monday. The most expensive day to stay in O Brien is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool lets you choose your budget, preferred location, and additional criteria. You can organize your results to display prices from lowest to highest, ensuring you see the most affordable hotels first. Additionally, you can refine your options by hotel type—if you select the Eco-certified filter, you'll find sustainable and eco-friendly hotels ready for booking.
  • Consider bundling your trip: You can save money by combining your O'Brien hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near O Brien

O Brien, Florida, is an ideal destination for outdoor enthusiasts and adventure seekers. Visitors can explore scenic national and state parks, enjoy the beauty of local rivers, and visit the library for a taste of local culture. Whether you're looking for thrilling activities or peaceful scenery, O Brien offers a range of attractions that cater to all types of travelers seeking an unforgettable experience in the heart of Florida.

  • Suwannee River: Located 6 miles from O Brien, the Suwannee River offers stunning scenery and a serene outdoor experience. Perfect for kayaking, fishing, or simply enjoying nature's beauty, this river is a fantastic spot for relaxation and adventure.
  • Ichetucknee Springs State Park: Situated 11 miles away, this state park is a gem for outdoor enthusiasts. With lush landscapes, crystal-clear springs, and various recreational activities, you can enjoy tubing, snorkeling, or hiking while soaking up the vibrant scenery.
  • Ichetucknee River: Also located 11 miles from O Brien, the Ichetucknee River provides a picturesque setting for tubing and canoeing. Its tranquil waters and scenic surroundings make it an ideal destination for a leisurely day in nature.

Best time to go to O Brien

The best time to visit O Brien is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly Low
February57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
March62.8°F (17.1°C)Light RainMostly SunnyAverageSlightly High
April69.1°F (20.6°C)Light RainMostly SunnyAverageAverage
May75.4°F (24.1°C)Light RainMostly SunnyModerately LowSlightly High
June80.2°F (26.8°C)Light RainMostly SunnyModerately HighAverage
July81.5°F (27.5°C)Light RainMostly SunnyModerately HighAverage
August81.3°F (27.4°C)Light RainMostly SunnyModerately HighSlightly Low
September77.9°F (25.5°C)Light RainMostly SunnyAverageAverage
October70.9°F (21.6°C)No RainMostly SunnyAverageSlightly High
November61.7°F (16.5°C)Light RainMostly SunnyModerately LowSlightly Low
December57.4°F (14.1°C)Light RainMostly SunnyAverageAverage

The nearest major airports for your trip to O Brien

To visit O'Brien, Florida, you can fly into three major airports. Jacksonville International Airport (JAX) is 81 miles away, with nearby hotels like the 4-star DoubleTree by Hilton Hotel Jacksonville Airport, only 0.3 miles from the terminal. Tallahassee International Airport (TLH) is 87 miles away, offering hotel options such as the 4-star DoubleTree by Hilton Hotel Tallahassee, located 5 miles from the airport. Gainesville Regional Airport (GNV) is the closest at 47 miles, with accommodations including the 4-star DoubleTree by Hilton Gainesville, situated 8 miles away. Each airport provides various transportation services to these hotels for added convenience.

Frequently asked questions

What is the best area to stay in O Brien?
The best area to stay in O'Brien, Florida, is near the I-10 and US-129 interchange, as this offers the most convenient access to local attractions and amenities.

This area, located directly at the intersection of the two major roadways, provides easy entry to O'Brien and the surrounding region. While O'Brien itself is a small, rural community, this hub offers the most centralized location for exploring the natural springs and outdoor activities North Florida is known for. You'll find the few local businesses and dining options clustered around this intersection.

For families, staying near this interchange is ideal because it minimizes travel time to popular destinations like the nearby natural springs. Many of these springs offer swimming, snorkeling, and canoeing, making them great for a day out with children. The convenience of quick access to the main roads means less time navigating and more time enjoying the outdoors.

Solo travelers also benefit from staying in this central location. It provides a practical base for exploring the area's natural beauty, such as kayaking on the Suwannee River or visiting local state parks.
When is the best time to go to O Brien?
The best time to visit O'Brien, Florida, is during the spring (March to May) and fall (September to November) for comfortable weather and pleasant outdoor activities.

During these seasons, O'Brien experiences mild temperatures, typically ranging from the low 70s to mid-80s Fahrenheit, with lower humidity than the summer months. This makes it ideal for enjoying the area's natural springs and outdoor recreation without the intense heat or the higher chance of thunderstorms characteristic of summer.

Travelers looking to explore the natural beauty of the area will find spring and fall particularly appealing. The cooler weather is great for swimming, kayaking, and tubing in the crystal-clear waters of the nearby Ichetucknee Springs State Park or the Suwannee River.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in O Brien.
How can I save on a O Brien hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible O Brien hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a O Brien hotel?
Prices for hotels in O Brien often vary, but you can find a great deal from $46 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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