Title: Top 10 Hotels in O Brien, FL (from $43) 2026 - Competitive Prices | Expedia.com

[O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides)

![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in O Brien

Resort

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&lodging=HOTEL_RESORT)

Pet-friendly

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&amenities=PETS)

Great for families

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&travelerType=family_friendly)

Pool

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&amenities=POOL)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&lodging=CABIN)

Hot tub

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&amenities=HOT_TUB)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&lodging=COTTAGE)

## Check prices for these dates

Tonight

[Feb 22 - Feb 23](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-22&endDate=2026-02-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 23 - Feb 24](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-23&endDate=2026-02-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for O Brien hotels

![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/a1c39a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds (Walk-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/578d088f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/758be2b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

[](https://www.expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

Alachua

9.4/10

Exceptional

(1,007 reviews)

"Staff and hotel were wonderful!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sandra

$113 nightly

$127 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

![3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/994169e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic House, 2 Bedrooms, Patio, River View | Terrace/patio](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/9fdd625a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Tent | Individually decorated, individually furnished, free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/ab1e5af8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Cabin, Resort View | In-room dining](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/c163ad60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Suwannee River Rendezvous

[](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information)

Mayo

8.8/10

Excellent

(24 reviews)

"Awesome place to stay, beautiful location and great accommodations. Friendly staff and lots to do!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lauren

$40 nightly

$43 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free on-the-go breakfast on weekdays](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/9112bbc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/c38f0eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/0011ea88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suite by Wyndham Lake City

[](https://www.expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

Lake City

8.8/10

Excellent

(1,085 reviews)

"Excellent place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Donovan

$104 nightly

$117 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/ce51e7f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/a49814cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/c1a6f9d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton Lake City

[](https://www.expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

Lake City

9.2/10

Wonderful

(1,009 reviews)

"Clean and staff was very kind "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosemary

$112 nightly

$126 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/b55b7c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking | Private kitchen | Fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/620ea62e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/6d948429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/dc866739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Home2 Suites by Hilton Lake City

[](https://www.expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

Lake City

9.4/10

Exceptional

(764 reviews)

"This is an excellent hotel while you roadtrip:)"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Desiree Moreno

$132 nightly

$149 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/w5753h3835x0y5-8b760fc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/5bb0fbdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/0124d3bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

Lake City

9.4/10

Exceptional

(1,000 reviews)

"The room was very clean and comfortable. Excellent breakfast and staff was very friendly and helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kenneth

$137 nightly

$154 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/fb3e9b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/1240f4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Lake City

[](https://www.expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

Lake City

9.0/10

Wonderful

(1,042 reviews)

"Great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jack

$82 nightly

$93 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/55219bf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/09328f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds | Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/4fd57c66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Live Oak by IHG

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

Live Oak

8.4/10

Very Good

(800 reviews)

"The room was clean. Bed was comfortable. Staff very nice. Breakfast was delicious. Great experience "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frank

$103 nightly

$114 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/1d4a6615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking | In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/35661d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/2dd8879c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Alachua I-75

[](https://www.expedia.com/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information)

Alachua

9.4/10

Exceptional

(486 reviews)

"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5\. Will definitely stay again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Libbi

$114 nightly

$128 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/4156d709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/6cb67822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed with Sofa bed | Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/39f90afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/ec822d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard By Marriott Lake City

[](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

Lake City

9.4/10

Exceptional

(210 reviews)

"Place was impeccable and fairly new. Only complaint were the beds and their hardness"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jon

$112 nightly

$126 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/44a144ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/7c89c912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/96b8648e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/43f69975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn & Suites Lake City by IHG

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information)

Lake City

8.6/10

Excellent

(1,002 reviews)

"Great place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

$103 nightly

$116 total

Mar 15 - Mar 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information)

![Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/90b674ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/bb1585dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/695b0a91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information)

Lake City

9.6/10

Exceptional

(1,002 reviews)

"The staff is great"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tana

$114 nightly

$128 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/84280a7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/96824aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/f4882d3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/c90d2ee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information)

Lake City

9.0/10

Wonderful

(203 reviews)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Guillermo

$107 nightly

$120 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information)

![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/a3ee2a3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/42e07503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/b5e4476a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/86100bd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vista Verde Farm Retreat

[](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information)

Lake City

9.8/10

Exceptional

(16 reviews)

"The property is great and I had a fabulous 3 night stay. Ana was fantastic and gave great suggestions for things to do in the area. Loved the location, pet friendly and beautiful. Would came back again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennie

$173 nightly

$194 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/74cd9358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/3a18c374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/3955224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/abc6b8bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 – Lake City, Fl – Medical Center

[](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

Lake City

8.2/10

Very Good

(109 reviews)

"Dog friendly and price."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

$60 nightly

$68 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

![Fountain](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/dffd0064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/66db6d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/5794d577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### BlueGem Motel

[](https://www.expedia.com/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information)

High Springs

9.2/10

Wonderful

(409 reviews)

"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julians

$80 nightly

$90 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information)

![Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/a1a4d6c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/918d16cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/5dfe9f55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/90277dd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Alachua Inn

[](https://www.expedia.com/Gainesville-Hotels-Travelodge-By-Wyndham-Alachua.h7326.Hotel-Information)

Alachua

5.8/10

(663 reviews)

"Room was clean and staff were courteous. The place isn't in a good area and, the outside doesn't look the same as the picture, it is worse. Staff were outside smoking and no one was at the front desk. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shirl

$85 nightly

$96 total

Feb 25 - Feb 26

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Travelodge-By-Wyndham-Alachua.h7326.Hotel-Information)

![Couples dining](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/7fbbc8b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/542db1e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fireplace](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/32ac9bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/51f0a7e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Putnam Lodge Hotel and Spa

[](https://www.expedia.com/Chiefland-Hotels-Putnam-Lodge-Hotel-And-Spa.h15731979.Hotel-Information)

Cross City

9.2/10

Wonderful

(369 reviews)

"Historic! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

William

$160 nightly

$176 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Chiefland-Hotels-Putnam-Lodge-Hotel-And-Spa.h15731979.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/f86787e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Sleeper Sofa | Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/2a6fa58f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/0820ad86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/w1024h1408x0y128-1c37bc4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Blanche 

[](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information)

Lake City

9.2/10

Wonderful

(171 reviews)

"Excellent Hotel! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jim

$147 nightly

$166 total

Mar 3 - Mar 4

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/5edd2e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/a54ec91f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/31f4ee27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/528c6fdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Lake City

[](https://www.expedia.com/Lake-City-Hotels-TownePlace-Suites-By-Marriott-Lake-City.h111220251.Hotel-Information)

Lake City

9.6/10

Exceptional

(126 reviews)

"Good hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frank

$159 nightly

$179 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-TownePlace-Suites-By-Marriott-Lake-City.h111220251.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09&regionId=3000431472&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## 

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Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

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## Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

[See all hotels in O Brien](https://www.expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09&adults=2&regionId=3000431472)

![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## Top O Brien Hotel Reviews

![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg)

### Best Western Plus Lake City

10/10 Excellent

"Check in staff was so welcoming and gracious. Room was clean."

[](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Courtyard By Marriott Lake City](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/9c441019_y.jpg)

### Courtyard By Marriott Lake City

10/10 Excellent

"Great staff and great room"

[](https://expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

![Hampton Inn & Suites Lake City](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673_y.jpg)

### Hampton Inn & Suites Lake City

10/10 Excellent

"Very friendly and accommodating for a large group traveling together. The breakfast was great! "

[](https://expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

![Holiday Inn & Suites Lake City by IHG](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/5d9b579a_y.jpg)

### Holiday Inn & Suites Lake City by IHG

10/10 Excellent

"Y3s"

[](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information)

![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg)

### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Greetings..All of the above & the safe atmosphere throughout my weekend stay 👍"

[](https://expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg)

### La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent

"great service!!"

[](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692_y.jpg)

### Americas Best Value Inn Lake City

10/10 Excellent

"It truly is a great value. I've traveled a lot throughout the eastern US over the past few years. America's Best Value Inn in Lake City is one of the cleanest places I've stayed in. The check-in staff was very pleasant and friendly. Not much of a breakfast, but there are local breakfast places nearby. "

[](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information)

![Days Inn by Wyndham Lake City I-75](https://images.trvl-media.com/lodging/1000000/20000/17700/17650/eb9ba6b8_y.jpg)

### Days Inn by Wyndham Lake City I-75

10/10 Excellent

"Great room and staff fantastic!"

[](https://expedia.com/Lake-City-Hotels-Days-Inn-By-Wyndham-Lake-City-I-75.h17650.Hotel-Information)

![Home2 Suites by Hilton Lake City](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/47d0ef07_y.jpg)

### Home2 Suites by Hilton Lake City

10/10 Excellent

"Great room, friendly staff, and quick check in"

[](https://expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

## More cheap stays in O Brien

![Motel 6 – Lake City, Fl – Medical Center](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL

$60 nightly

$68 total

Mar 1 - Mar 2

Total with taxes and fees

8.2/10 Very Good! (109 reviews)

[](https://expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

$82 nightly

$93 total

Mar 8 - Mar 9

Total with taxes and fees

9/10 Wonderful! (1,042 reviews)

[](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL

$103 nightly

$114 total

Mar 15 - Mar 16

Total with taxes and fees

8.4/10 Very Good! (800 reviews)

[](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### La Quinta Inn & Suite by Wyndham Lake City

165NW CALI DRIVE Lake City FL

$104 nightly

$117 total

Mar 1 - Mar 2

Total with taxes and fees

8.8/10 Excellent! (1,085 reviews)

[](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/1f67a534_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

$112 nightly

$126 total

Mar 1 - Mar 2

Total with taxes and fees

9.2/10 Wonderful! (1,009 reviews)

[](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

![Hampton Inn & Suites Lake City](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn & Suites Lake City

450 SW Florida Gateway Drive Lake City FL

$137 nightly

$154 total

Feb 23 - Feb 24

Total with taxes and fees

9.4/10 Exceptional! (1,000 reviews)

[](https://expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

## Hotels in O Brien with star-rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

20 properties

[](https://expedia.com/3Star-O-Brien-Hotels.s30-0-d3000431472.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

65 properties

[](https://expedia.com/2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in O Brien?

> This area, located directly at the intersection of the two major roadways, provides easy entry to O'Brien and the surrounding region. While O'Brien itself is a small, rural community, this hub offers the most centralized location for exploring the natural springs and outdoor activities North Florida is known for. You'll find the few local businesses and dining options clustered around this intersection.
> 
>   
> For families, staying near this interchange is ideal because it minimizes travel time to popular destinations like the nearby natural springs. Many of these springs offer swimming, snorkeling, and canoeing, making them great for a day out with children. The convenience of quick access to the main roads means less time navigating and more time enjoying the outdoors.
> 
>   
> Solo travelers also benefit from staying in this central location. It provides a practical base for exploring the area's natural beauty, such as kayaking on the Suwannee River or visiting local state parks.

### When is the best time to go to O Brien?

> During these seasons, O'Brien experiences mild temperatures, typically ranging from the low 70s to mid-80s Fahrenheit, with lower humidity than the summer months. This makes it ideal for enjoying the area's natural springs and outdoor recreation without the intense heat or the higher chance of thunderstorms characteristic of summer.
> 
>   
> Travelers looking to explore the natural beauty of the area will find spring and fall particularly appealing. The cooler weather is great for swimming, kayaking, and tubing in the crystal-clear waters of the nearby Ichetucknee Springs State Park or the Suwannee River.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a O Brien hotel booking with Expedia?

> \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

### How much is the nightly rate at a O Brien hotel?

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- [Ichetucknee Springs State Park ](https://www.expedia.com/Ichetucknee-Springs-State-Park-Florida.d6285986.Vacation-Attraction)
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- [Fort White Vacations ](https://www.expedia.com/Fort-White.d6286968.Destination-Travel-Guides)
- [Bob's River Place ](https://www.expedia.com/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction)
- [First Federal Sportsplex ](https://www.expedia.com/First-Federal-Sportsplex-Live-Oak.d6185397.Vacation-Attraction)

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- [Branford Vacation Rentals ](https://www.expedia.com/Branford-Vacation-Rentals.d6188028.Travel-Guide-VacationRentals)
- [Mcalpin Vacation Rentals ](https://www.expedia.com/Mcalpin-Vacation-Rentals.d3000345299.Travel-Guide-VacationRentals)
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- [Things to do in Fort White ](https://www.expedia.com/Things-To-Do-In-Fort-White.d6286968.Travel-Guide-Activities)

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