$510 Cheap Flights from Lyon (LYS) to Des Moines (DSM)

View $510 flight on Mon, Nov 17, 2025Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to Des Moines International Airport (DSM)

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Cheap Flights from Lyon to Des Moines (LYS-DSM)

Prices were available within the past 7 days and start at $510 for one-way flights and $856 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 17 - Mon, Jan 5
LYS
Lyon
DSM
Des Moines
$856 Roundtrip, found 6 days ago
$856
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Dec 17 from Lyon to Des Moines, returning Mon, Jan 5, priced at $856 found 6 days ago
Delta
Tue, Dec 23 - Sun, Jan 4
LYS
Lyon
DSM
Des Moines
$883 Roundtrip, found 6 days ago
$883
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 23 from Lyon to Des Moines, returning Sun, Jan 4, priced at $883 found 6 days ago
Delta
Wed, Dec 17 - Tue, Dec 30
LYS
Lyon
DSM
Des Moines
$889 Roundtrip, found 6 days ago
$889
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 17 from Lyon to Des Moines, returning Tue, Dec 30, priced at $889 found 6 days ago
American Airlines
Thu, Dec 18 - Mon, Jan 5
LYS
Lyon
DSM
Des Moines
$897 Roundtrip, found 6 days ago
$897
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 18 from Lyon to Des Moines, returning Mon, Jan 5, priced at $897 found 6 days ago
KLM
Tue, Dec 23 - Sun, Jan 4
LYS
Lyon
DSM
Des Moines
$903 Roundtrip, found 6 days ago
$903
Roundtrip
found 6 days ago
Select KLM flight, departing Tue, Dec 23 from Lyon to Des Moines, returning Sun, Jan 4, priced at $903 found 6 days ago
KLM
Tue, Dec 23 - Tue, Dec 30
LYS
Lyon
DSM
Des Moines
$909 Roundtrip, found 6 days ago
$909
Roundtrip
found 6 days ago
Select KLM flight, departing Tue, Dec 23 from Lyon to Des Moines, returning Tue, Dec 30, priced at $909 found 6 days ago
Delta
Tue, Dec 16 - Tue, Dec 30
LYS
Lyon
DSM
Des Moines
$912 Roundtrip, found 6 days ago
$912
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 16 from Lyon to Des Moines, returning Tue, Dec 30, priced at $912 found 6 days ago
Delta
Tue, Dec 16 - Mon, Jan 5
LYS
Lyon
DSM
Des Moines
$917 Roundtrip, found 6 days ago
$917
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 16 from Lyon to Des Moines, returning Mon, Jan 5, priced at $917 found 6 days ago
British Airways
Thu, Dec 18 - Thu, Jan 1
LYS
Lyon
DSM
Des Moines
$1,067 Roundtrip, found 6 days ago
$1,067
Roundtrip
found 6 days ago
Select British Airways flight, departing Thu, Dec 18 from Lyon to Des Moines, returning Thu, Jan 1, priced at $1,067 found 6 days ago
Air France
Sun, Dec 21 - Sun, Jan 4
LYS
Lyon
DSM
Des Moines
$1,106 Roundtrip, found 6 days ago
$1,106
Roundtrip
found 6 days ago
Select Air France flight, departing Sun, Dec 21 from Lyon to Des Moines, returning Sun, Jan 4, priced at $1,106 found 6 days ago

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $510 or cheap return flight from $856 from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
December is the most affordable month to fly from LYS to DSM. Traveling outside of peak seasons is often the key to finding a great deal.
What is the cheapest airline that flies from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll take you from LYS to DSM. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
You'll need to hop on a flight with a layover if you're traveling from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from LYS to DSM?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
Select a flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from LYS to DSM shortly before your journey is usually more expensive. But if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a LYS to DSM flight and hotel package?
You'll typically save money by booking a LYS to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your ideal flights and accommodations, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
In most cases, you can cancel or modify your LYS to DSM flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you'd like further information, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Saint-Exupery
Destination airport
Des Moines Intl.
Roundtrip price
$855
Distance
4608 mi

Book with confidence

Book with confidence

Lyon to Des Moines Flights

The cheapest times to fly from Lyon to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Des Moines are during the month of December. You can find some of the cheapest flights from Lyon to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Des Moines

Sunday is one of the best days to book for cheap flights from Lyon to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $510 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lyon to Des Moines Flights

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*Available to One Key members.