$809 Cheap Flights from Lyon (LYS) to Des Moines (DSM)

View $809 flight on Wed, Sep 3, 2025Opens in a new window

Popular airlines from Saint-Exupery Airport (LYS) to Des Moines International Airport (DSM)

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Cheap Flights from Lyon to Des Moines (LYS-DSM)

Prices were available within the past 7 days and start at $809 for one-way flights and $737 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$737 Roundtrip, found 4 days ago
$737
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $737 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$931 Roundtrip, found 4 days ago
$931
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $931 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$939 Roundtrip, found 4 days ago
$939
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $939 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$981 Roundtrip, found 4 days ago
$981
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $981 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$983 Roundtrip, found 4 days ago
$983
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $983 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$1,030 Roundtrip, found 4 days ago
$1,030
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $1,030 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$1,037 Roundtrip, found 4 days ago
$1,037
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $1,037 found 4 days ago
Lufthansa
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$1,044 Roundtrip, found 4 days ago
$1,044
Roundtrip
found 4 days ago
Select Lufthansa flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $1,044 found 4 days ago
British Airways
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$1,052 Roundtrip, found 4 days ago
$1,052
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $1,052 found 4 days ago
Iberia
Sat, Aug 23 - Sat, Aug 30
LYS
Lyon
DSM
Des Moines
$1,110 Roundtrip, found 4 days ago
$1,110
Roundtrip
found 4 days ago
Select Iberia flight, departing Sat, Aug 23 from Lyon to Des Moines, returning Sat, Aug 30, priced at $1,110 found 4 days ago
Flights from Lyon (LYS) to Des Moines (DSM)
Origin airport
Saint-Exupery
Destination airport
Des Moines Intl.
Roundtrip price
$737
Distance
4608 mi

Lyon to Des Moines Flights

The cheapest times to fly from Lyon to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to Des Moines are during the month of August. You can find some of the cheapest flights from Lyon to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lyon to Des Moines

Sunday is one of the best days to book for cheap flights from Lyon to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lyon to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $809 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from LYS to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LYS to DSM?
The cheapest flights from LYS to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LYS to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from LYS to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
You'll need to hop on a flight with a layover if you're traveling from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from LYS to DSM?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
Select a flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from LYS to DSM shortly before your journey is usually more expensive. But if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a LYS to DSM flight and hotel package?
You'll typically save money by booking a LYS to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your ideal flights and accommodations, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Des Moines Intl. Airport (DSM)?
In most cases, you can cancel or modify your LYS to DSM flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you'd like further information, head to our Customer Service portal.

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*Available to One Key members.