$110 Cheap Flights from Tampa (TPA) to Des Moines (DSM)

View $110 flight on Thu, Nov 13, 2025Opens in a new window

Popular airlines from Tampa Intl. Airport (TPA) to Des Moines International Airport (DSM)

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Cheap Flights from Tampa to Des Moines (TPA-DSM)

Prices were available within the past 7 days and start at $110 for one-way flights and $184 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$184 Roundtrip, found 5 days ago
$184
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $184 found 5 days ago
Southwest Airlines
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$189 Roundtrip, found 5 days ago
$189
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $189 found 5 days ago
Southwest Airlines
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$198 Roundtrip, found 5 days ago
$198
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $198 found 5 days ago
Southwest Airlines
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$204 Roundtrip, found 5 days ago
$204
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $204 found 5 days ago
Delta
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$208 Roundtrip, found 5 days ago
$208
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $208 found 5 days ago
Southwest Airlines
Sat, Sep 20 - Mon, Sep 22
TPA
Tampa
DSM
Des Moines
$218 Roundtrip, found 5 days ago
$218
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Sep 20 from Tampa to Des Moines, returning Mon, Sep 22, priced at $218 found 5 days ago
American Airlines
Thu, Aug 28 - Sat, Aug 30
TPA
Tampa
DSM
Des Moines
$220 Roundtrip, found 6 days ago
$220
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Aug 28 from Tampa to Des Moines, returning Sat, Aug 30, priced at $220 found 6 days ago
United
Sun, Sep 28 - Mon, Sep 29
TPA
Tampa
DSM
Des Moines
$228 Roundtrip, found 5 days ago
$228
Roundtrip
found 5 days ago
Select United flight, departing Sun, Sep 28 from Tampa to Des Moines, returning Mon, Sep 29, priced at $228 found 5 days ago
Delta
Sun, Aug 17 - Tue, Aug 19
TPA
Tampa
DSM
Des Moines
$229 Roundtrip, found 5 days ago
$229
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Aug 17 from Tampa to Des Moines, returning Tue, Aug 19, priced at $229 found 5 days ago
Frontier Airlines
Wed, Oct 1 - Wed, Oct 22
TPA
Tampa
DSM
Des Moines
$284 Roundtrip, found 4 days ago
$284
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Oct 1 from Tampa to Des Moines, returning Wed, Oct 22, priced at $284 found 4 days ago

Find the cheapest month to fly from Tampa (TPA) to Des Moines (DSM)

November is typically the cheapest month to fly

From $118 - $469 per traveler.

Graph displaying average flight prices per month

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $375
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $375
Flights from Tampa (TPA) to Des Moines (DSM)
Origin airport
Tampa Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$183
Distance
1126 mi

Frequently asked questions

How much does a flight from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from TPA to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TPA to DSM?
The cheapest flights from TPA to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM)?
You can't catch a nonstop flight to Des Moines Intl. Airport (DSM) from Tampa, FL (TPA-Tampa Intl.). However, you can seamlessly travel to Des Moines without any layovers by leaving from Sarasota-Bradenton Intl. Airport (SRQ).
What is the cheapest airline that flies from TPA to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from TPA to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM)?
There aren't any daily direct flights from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from TPA to DSM?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM)?
To touch down at Des Moines Intl. Airport (DSM) without delays, pick a flight that leaves from Tampa Intl. Airport (TPA) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM) last-minute?
Booking your flight from TPA to DSM shortly before your journey is generally more expensive. But if you're flexible with your travel times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a TPA to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a TPA to DSM flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one convenient place will take the hassle out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Tampa Intl. Airport (TPA) to Des Moines Intl. Airport (DSM)?
Usually, it's possible to cancel or reschedule your TPA to DSM flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.