Santa Croce Vacations from $589

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $982, price is now $589 per person
$589
per person
Jan 10 - Jan 15
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.6/10 Good! (1,002 reviews)
Close to train station and everything you need.

Reviewed on Nov 21, 2025

Hotel Regency

Hotel Regency

5 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,408, price is now $924 per person
$924
per person
Jan 10 - Jan 15
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.4/10 Exceptional! (439 reviews)
Loved it! Great place and very convenient

Reviewed on Jul 4, 2025

Villa Cora

Villa Cora

5 out of 5
Oltrarno
Price was $2,708, price is now $1,841 per person
$1,841
per person
Jan 3 - Jan 7
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.8/10 Exceptional! (467 reviews)
Nice property and staff.

Reviewed on Nov 13, 2025

Villa Tolomei Hotel & Resort

Villa Tolomei Hotel & Resort

5 out of 5
Oltrarno
Price was $1,126, price is now $775 per person
$775
per person
Feb 10 - Feb 16
found 16 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.8/10 Excellent! (399 reviews)
Staff is wonderful and kind, very accommodating. We stayed here with a lot of family members for our wedding, we got a beautiful spacious suite with the best courtyard views. The rooms are so beautifully designed, the whole villa is just dreamy and true Tuscany. Breakfast is amazing with so many options and so fresh, so delicious! Service is great too. Overall cannot beat the location. We also held our wedding reception dinner here and the food and service and spaces we used were amazing. They even gave us complimentary bottle of champagne and homemade cookies in our room with a lovely note. Overall, we hope to be back!

Reviewed on Nov 25, 2025

Hotel Lungarno - Lungarno Collection

Hotel Lungarno - Lungarno Collection

5 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $1,667, price is now $1,159 per person
$1,159
per person
Feb 7 - Feb 11
found 2 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (593 reviews)
Excellent location! Truly a 5 star hotel ! Great service, breakfast, and service . Bedrooms were clean! Bathrooms were excellent!

Reviewed on Nov 19, 2025

Black Friday Sale

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Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $219 total per night from Dec 9 to Dec 10
$219 total
Dec 9 - Dec 10
Total with taxes and fees
9.2/10 Wonderful! (980 reviews)
Clean, comfortable room/beds. Great location. Staff was very, very attentive. Very good breakfast. A special shout out to Concierge Extraordinaire Walter, who helped us out way beyond what I expected! I

Reviewed on Nov 18, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44 Florence FI
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $142 total per night from Dec 18 to Dec 19
$142 total
Dec 18 - Dec 19
Total with taxes and fees
8/10 Very Good! (940 reviews)
Everything was great. Thank you

Reviewed on Nov 14, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri

Hotel Balestri

4 out of 5
Piazza Mentana 7 Florence FI
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $146 total per night from Dec 14 to Dec 15
$146 total
Dec 14 - Dec 15
Total with taxes and fees
9.2/10 Wonderful! (998 reviews)
Lovely hotel.

Reviewed on Nov 26, 2025

Hotel Balestri
See all 835 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

4/5(5 reviews)

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

4.5/5(990 reviews)

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and notable monuments.

National Central Library of Florence

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$27
per adult
78% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$75
per adult
92% of travellers recommend
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti
Florence half day combo tour with David, Uffizi & Duomo

Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia

$50
per adult
90% of travellers recommend
Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.