Santa Croce Vacations from $724

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Price was $1,024, price is now $724 per person
$724
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
15.6/10 Exceptional! (1,000 reviews)
Clean but small Breakfast is ok location is perfect

Reviewed on Nov 15, 2025

Bernini Palace

Bernini Palace

5 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was $4,245, price is now $3,023 per person
$3,023
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Boston (BOS) to Florence (FLR)
19.2/10 Exceptional! (1,007 reviews)
We enjoyed our stay at Bernini Palace. Our room was fairly spacious and we liked the large modern bathroom. The breakfast was quite good with a great selection that included our cappuccinos and also offers mimosas. The location was perfect for our time in Florence! We would definitely stay again.

Reviewed on Nov 16, 2025

Arte' Boutique Hotel

Arte' Boutique Hotel

4 out of 5
Historic Centre of Florence
Price was $2,083, price is now $1,502 per person
$1,502
per person
Jan 3 - Jan 9
found 8 hours ago
Roundtrip flight included
Los Angeles (LAX) to Florence (FLR)
9.8/10 Exceptional! (292 reviews)
Good location and nice hotel

Reviewed on Nov 16, 2025

Hotel Duomo Firenze

Hotel Duomo Firenze

3 out of 5
Historic Centre of Florence
Price was $1,208, price is now $904 per person
$904
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
18.4/10 Exceptional! (1,002 reviews)
Muy buena atencion !!! 100% recomendado

Reviewed on Nov 14, 2025

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Price was $986, price is now $739 per person
$739
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
15.2/10 Exceptional! (1,002 reviews)
Convenient location to fast food and train station

Reviewed on Nov 7, 2025

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $178 total per night from Dec 18 to Dec 19
$178 total
Dec 18 - Dec 19
Total with taxes and fees
9.2/10 Wonderful! (978 reviews)
Wonderful and clean room. Staff were friendly and helpful. 25 minute or less walk to major sites. Was nice to feel at the edge of the city for less noise and view of the river but still walkable to everything.

Reviewed on Nov 9, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44 Florence FI
$124 nightly
The price is $153 total per night from Nov 24 to Nov 25
$153 total
Nov 24 - Nov 25
Total with taxes and fees
8/10 Very Good! (939 reviews)
Everything was great. Thank you

Reviewed on Nov 14, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri

Hotel Balestri

4 out of 5
Piazza Mentana 7 Florence FI
Fully refundable
$133 nightly
The price is $162 total per night from Dec 8 to Dec 9
$162 total
Dec 8 - Dec 9
Total with taxes and fees
9.2/10 Wonderful! (994 reviews)
View was beautiful. No balcony as advertised

Reviewed on Nov 14, 2025

Hotel Balestri
See all 832 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and notable monuments.

National Central Library of Florence

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$27
per adult
78% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
VIP SKIP THE LINE WITH ELVIS : Love the David GUIDED EXPERIENCE

Skip the line : David Guided Experience

$29
per adult
76% of travellers recommend
Skip the line : David Guided Experience
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$76
per adult
92% of travellers recommend
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.