Santa Croce Vacations from $677

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
Save 100% on your flight
per person
Sep 11 - Sep 15
found 1 day ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
7.8/10 Good! (1,000 reviews)
Excellent Location, friendly staff and good standard room

Reviewed on Jul 1, 2025

Tenuta di Artimino Member of Meliá Collection

Tenuta di Artimino Member of Meliá Collection

4 out of 5
Save 100% on your flight
per person
Sep 25 - Sep 30
found 1 day ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
9.4/10 Exceptional! (116 reviews)
One of the most amazing hotels I’ve ever stayed.

Reviewed on Jun 23, 2025

Villa Cora

Villa Cora

5 out of 5
Oltrarno
Save 100% on your flight
per person
Sep 19 - Sep 26
found 21 hours ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
9.8/10 Exceptional! (448 reviews)
lovely and a short walk to the center of town.....

Reviewed on Jun 30, 2025

Monastero di Cortona Hotel & Spa

Monastero di Cortona Hotel & Spa

5 out of 5
Cortona Old Town
Save 100% on your flight
per person
Sep 19 - Sep 26
found 21 hours ago
Roundtrip flight included
New York (NYC) to Florence (FLR)
10/10 Exceptional! (212 reviews)
Top Tier Hotel. Great amenities and service!!

Reviewed on Jun 3, 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
per person
Sep 23 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,000 reviews)
Our group of three made it though challenging to find initially as located halfway down an alley. But once found the check in was easy and friendly. The room size was ok and great air conditioning. The only down side was the wifi which never came up during our 2 day stay. The elevator did go out but came back on just before check out. Friendly staff was another positive.

Reviewed on Jul 3, 2025

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santa Croce Hotel Deals

Plaza Hotel Lucchesi
Plaza Hotel Lucchesi
4 out of 5
Lungarno Della Zecca Vecchia 38, Florence, FI
Fully refundableReserve now, pay when you stay
$260 nightly
The price is $303 total per night from Aug 1 to Aug 2
$303 total
Aug 1 - Aug 2
Total includes taxes and fees
9.2/10 Wonderful! (979 reviews)
"It was a very nice hotel, in a walking distance of everything."

Reviewed on Jul 1, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo
FH55 Grand Hotel Mediterraneo
4 out of 5
Lungarno del Tempio, 44, Florence, FI
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $159 total per night from Jul 23 to Jul 24
$159 total
Jul 23 - Jul 24
Total includes taxes and fees
8/10 Very Good! (868 reviews)
"Everyone working here was great. Very polite and helpful. Great air conditioned rooms . Breakfast was included . Evening dinner here was also very good."

Reviewed on Jun 29, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri
Hotel Balestri
4 out of 5
Piazza Mentana 7, Florence, FI
Fully refundableReserve now, pay when you stay
$188 nightly
The price is $224 total per night from Jul 31 to Aug 1
$224 total
Jul 31 - Aug 1
Total includes taxes and fees
9.2/10 Wonderful! (947 reviews)
"Service was top notch. We had to wait 10 minutes for our room to be ready but they were great about everything and accommodating an early morning checkout with bag breakfasts for us. Location is also great next to the river and near major attractions in the city."

Reviewed on Jul 3, 2025

Hotel Balestri
See all 842 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Basilica of Santa Croce which includes heritage architecture, a statue or sculpture and religious aspects

Basilica of Santa Croce

4.5/5(990 reviews)

Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.

Basilica of Santa Croce
Piazza Santa Croce featuring a statue or sculpture

Piazza Santa Croce

4/5(5 reviews)

Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Piazza Santa Croce
Not a hidden gem, but still a great spot.

National Central Library of Florence

Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and notable monuments.

National Central Library of Florence

Things to do

Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$32
per adult
98% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
People riding scooters in Tuscany

Tuscany Vintage Vespa Tour

$150
per adult
100% of travellers recommend
Tuscany Vintage Vespa Tour
Santa Maria Novella

Visit Florence in golf car with Fiorentine tuorist guide

$80
per adult
100% of travellers recommend
Visit Florence in golf car with Fiorentine tuorist guide
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.