Seneca Vacations from $379

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The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.

3 out of 5
Price was $440, price is now $379 per person
$379
per person
Jan 22 - Jan 26
found 1 day ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Greenville (GSP)
8.8/10 Excellent! (786 reviews)
Clean room, friendly staff and great breakfast options.

Reviewed on Dec 16, 2025

Park Place Apartments by Landing

Park Place Apartments by Landing

4 out of 5
Price was $576, price is now $473 per person
$473
per person
Jan 22 - Jan 26
found 1 day ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Greenville (GSP)
7.6/10 Good! (41 reviews)
The concept is nice, but the execution/completion would make it nicer. Power went out for over 32 hrs (not sure if it was longer because I left for better accomodations), alarms went off, there is no alternative to the steep stairs due to the elevators not being complete. It was cool for the few hours I had power.

Reviewed on Jul 30, 2025

Mint House Greenville - Downtown

Mint House Greenville - Downtown

4 out of 5
Greenville Downtown
Price was $769, price is now $647 per person
$647
per person
Jan 22 - Jan 26
found 1 day ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Greenville (GSP)
9.2/10 Wonderful! (763 reviews)
This was a very nice place to stay for a decent price. It was just one block from main street and very walkable. The Mint House customer service reps are very prompt in answering questions. We hope to be able to return in the near future.

Reviewed on Dec 17, 2025

Hotel Hartness

Hotel Hartness

4 out of 5
Price was $720, price is now $622 per person
$622
per person
Feb 6 - Feb 8
found 1 day ago
Roundtrip non-stop flight included
Fresno (FAT) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Beautiful hotel, very nice staff, lots of space to work remotely

Reviewed on Dec 15, 2025

Hilton Greenville

Hilton Greenville

3.5 out of 5
Price was $624, price is now $563 per person
$563
per person
Feb 6 - Feb 8
found 1 day ago
Roundtrip non-stop flight included
Fresno (FAT) to Greenville (GSP)
8.2/10 Very Good! (1,005 reviews)
Awesome and super clean

Reviewed on Dec 19, 2025

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Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
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Downtown

2 out of top 10 points of interest in this area

While visiting Downtown, you might make a stop by sights like Seneca Historic District and Bertha Lee Strickland Cultural Museum.

Find hotels in Downtown

Seneca Hotel Deals

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $87 total per night from Dec 27 to Dec 28
$87 total
Dec 27 - Dec 28
Total with taxes and fees
7.8/10 Good! (665 reviews)
Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion.

Reviewed on Nov 28, 2025

Quality Inn Seneca Clemson Area US-123
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Dec 20 to Dec 21
$135 total
Dec 20 - Dec 21
Total with taxes and fees
8.8/10 Excellent! (1,000 reviews)
Enjoyed our stay.

Reviewed on Dec 15, 2025

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $107 total per night from Dec 25 to Dec 26
$107 total
Dec 25 - Dec 26
Total with taxes and fees
9.2/10 Wonderful! (792 reviews)
Michail was the best. He was so welcoming, helpful and professional. Parking was easy and rooms were nice and clean. I will definitely stay again.

Reviewed on Dec 13, 2025

Tru by Hilton Seneca Clemson
See all 1,646 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $379 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.