Seneca Vacations from $408

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Seneca vacation packages

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
Price was $484, price is now $408 per person
$408
per person
Jan 9 - Jan 13
found 1 day ago
Roundtrip non-stop flight included
Colorado Springs (COS) to Greenville (GSP)
8.6/10 Excellent! (1,005 reviews)
The hotel lobby was very nice. My room was ok. The bathtub was slippery. The room was also cold even though the thermostat said 72. It was definitely 67. I had to go and get a refill of Kleenex and TP. The bed was comfortable. The room was clean. The hallway was really cold. The heater is definitely broken.

Reviewed on Nov 29, 2025

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
Price was $539, price is now $433 per person
$433
per person
Jan 9 - Jan 13
found 1 day ago
Roundtrip non-stop flight included
Colorado Springs (COS) to Greenville (GSP)
8.6/10 Excellent! (711 reviews)
Heat didn't work, but staff quickly gave us another room and a little upgraded.

Reviewed on Dec 4, 2025

Hotel Hartness

Hotel Hartness

4 out of 5
Price was $546, price is now $446 per person
$446
per person
Jan 16 - Jan 19
found 21 hours ago
Roundtrip flight included
Miami (MIA) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Incredible hotel and property! We were extremely impressed!

Reviewed on Dec 3, 2025

Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.

3 out of 5
Price was $562, price is now $460 per person
$460
per person
Jan 9 - Jan 13
found 1 day ago
Roundtrip non-stop flight included
Colorado Springs (COS) to Greenville (GSP)
8.8/10 Excellent! (786 reviews)
Room clean.nice stay would like a free buffet though for breakfast

Reviewed on Nov 23, 2025

The Bleckley Inn

The Bleckley Inn

3.5 out of 5
Price was $823, price is now $683 per person
$683
per person
Jan 9 - Jan 13
found 7 hours ago
Roundtrip non-stop flight included
Colorado Springs (COS) to Greenville (GSP)
9.8/10 Exceptional! (405 reviews)
Cleanest hotel I've ever seen, nicest staff I've ever encountered, and the coolest rooms you can find in Anderson. My suite had a full kitchen, living area, and had a really impressive atmosphere. A lovely place to stay

Reviewed on Nov 29, 2025

Don't see what you're looking for?
See all available trips from Columbus to Seneca
View all trips

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca
Default Image

Downtown

2 out of top 10 points of interest in this area

While visiting Downtown, you might make a stop by sights like Seneca Historic District and The Gauntlet.

Find hotels in Downtown

Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Dec 8 to Dec 9
$135 total
Dec 8 - Dec 9
Total with taxes and fees
8.8/10 Excellent! (1,001 reviews)
Clean room, outdoor fire pit but restaurant closed was hoping for a good meal

Reviewed on Dec 4, 2025

Lakeside Lodge Clemson
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Dec 24 to Dec 25
$74 total
Dec 24 - Dec 25
Total with taxes and fees
6.8/10 (718 reviews)
Very nice and helpful at the fronte desk. Nice room and very comfortable bed

Reviewed on Nov 30, 2025

Days Inn by Wyndham Seneca / Clemson Area
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
$95 nightly
The price is $105 total per night from Dec 22 to Dec 23
$105 total
Dec 22 - Dec 23
Total with taxes and fees
9.2/10 Wonderful! (788 reviews)
safe

Reviewed on Dec 2, 2025

Tru by Hilton Seneca Clemson
See all 1,645 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seneca Vacation Packages

Seneca Essential Information

Language
English
Currency
U.S dollars
Population
8,300
Max Temp Winter
50ºF
Max Temp Summer
90ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Seneca vacation package cost?
You'll find cheap prices from $408 on Expedia for your Seneca break. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Seneca costs.
What are the cheapest months to go to Seneca?
You can typically find lower rates and better availability in September, October and December. Browse our cheap Seneca vacation packages and you could land some great off-season discounts.
How many days is enough for Seneca?
Usually, a handful of days is enough to tick off the top attractions during your Seneca vacation. But if you prefer to have more time to rest or go on day tours, consider extending your itinerary.
How to find the best Seneca package deals?
Start your search for a Seneca package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Seneca package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Seneca escape underway.
Is it cheaper to book a Seneca vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll generally get a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Seneca vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Seneca?
If you've got your Seneca travel dates locked in, book as early as you can to grab some fantastic deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Seneca vacation packages?
Set off on your perfect escape to Seneca with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until your next payday — we've joined forces with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, you can easily stay on budget and snap up cheap deals before they disappear.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.