
Seneca Vacations from $575
Book a Hotel + Flight or Car together to unlock savings
Photo by Deidree DeHart
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
The Latest Seneca vacation packages
Price found within the past 48 hours. Click for updated prices.

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Price was $694, price is now $575 per person
$575
per person
Nov 20 - Nov 24
found 1 day ago
Roundtrip non-stop flight included
Fargo (FAR) to Greenville (GSP)
8.6/10 Excellent! (1,000 reviews)
We were very happy that we chose Crowne Plaza Hotel in Greenville for an important event that we were attending in Greenville. We would return for sure. It is very close to the airport, and easy to get on the I-385 to get around Greenville. We loved our room on the 6th floor. It was nice and quiet, had everything that we needed. The bed was very comfortable, great Keurig coffee maker, , fridge. Lots of space for our belongings. They have a shuttle that will take you places close to the hotel if need be. The gentleman was very kind and friendly. We did not use the shuttle but he did tell us where we could get a few grocery items. It was perfect. The staff that checked us in were awesome, very friendly, got our room early which was so appreciated. If I had to say something negative, I would say however that the lady at the front desk for the remainder of our stay was not very friendly or helpful, but that was a minor detail as everything else was fantastic.
Reviewed on Sep 16, 2025

Liberty Hall Bed and Breakfast
Save 100% on your flight
Price was $1,474, price is now $1,014 per person
$1,014
per person
Oct 30 - Nov 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
10/10 Exceptional! (71 reviews)
Excellent property with spacious rooms and a great front porch with rocking chairs to relax in. Fabulous breakfast every day. But most important was the staff. Angela and Micheal were very welcoming and ready to help with anything you might need. Would definitely return.
Reviewed on Sep 2, 2025


Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
Price was $1,466, price is now $1,123 per person
$1,123
per person
Nov 20 - Nov 24
found 1 day ago
Roundtrip non-stop flight included
Fargo (FAR) to Greenville (GSP)
9.6/10 Exceptional! (378 reviews)
Gorgeous property with over the top extras and amenities. Just booked a future stay for my son and his wife who will be visiting from Oklahoma in January, so they can experience this beautiful place.
Reviewed on Sep 18, 2025

Comfort Inn & Suites Clemson - University Area
Price was $1,400, price is now $1,074 per person
$1,074
per person
Oct 30 - Nov 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Greenville (GSP)
8.2/10 Very Good! (1,011 reviews)
Very good value for this hotel considering its location near Clemson's downtown. Comfortable beds.
Reviewed on Sep 15, 2025
Where to stay in Seneca
Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca

Downtown
2 out of top 10 points of interest in this area
While visiting Downtown, you might make a stop by sights like Seneca Historic District and Oconee County Library Seneca Branch.
Seneca Hotel Deals

Lakeside Lodge Clemson
13500 Clemson Blvd, Seneca, SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Sep 21 to Sep 22
$135 total
Sep 21 - Sep 22
Total with taxes and fees
8.8/10 Excellent! (1,005 reviews)
"Very pleasant stay!"
Reviewed on Sep 9, 2025

Best Western Seneca-Clemson
511 Bypass Highway 123, Seneca, SC
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $93 total per night from Sep 25 to Sep 26
$93 total
Sep 25 - Sep 26
Total with taxes and fees
8.2/10 Very Good! (611 reviews)
"The staff were great in answering questions. Room was clean. Appreciated having the microwave and refrigerator in the room. There were enough towels for every member of our party. The free breakfast was excellent. Loved the variety. It may have been in small print in the reservation, but was surprised ..."
Reviewed on Sep 8, 2025

Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street, Seneca, SC
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $133 total per night from Oct 16 to Oct 17
$133 total
Oct 16 - Oct 17
Total with taxes and fees
9.2/10 Wonderful! (634 reviews)
"Everything was good"
Reviewed on Aug 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Flights from Utica
- Flights from Oconee County Regional
- Flights from Atlanta (ATL) to Clemson (CEU)
- Flights from Charlotte (CLT) to Clemson (CEU)
- Flights from New York (JFK) to Clemson (CEU)
- Flights from Boston (BOS) to Clemson (CEU)
- Flights from Asheville (AVL) to Clemson (CEU)
- Flights from Washington (DCA) to Clemson (CEU)
- Flights from Philadelphia (PHL) to Clemson (CEU)
- Flights from Miami (MIA) to Clemson (CEU)
- Flights from Tampa (TPA) to Clemson (CEU)
- Flights from Chicago (ORD) to Clemson (CEU)
- Flights from Nashville (BNA) to Clemson (CEU)
- Flights from Pittsburgh (PIT) to Clemson (CEU)
- Flights from Dallas (DFW) to Clemson (CEU)
- Flights to Oconee County Regional
- Flights from Tallahassee (TLH) to Clemson (CEU)
- Flights from Baltimore (BWI) to Clemson (CEU)
- Flights from Hartford (BDL) to Clemson (CEU)
- Flights from Austin (AUS) to Clemson (CEU)
- Flights from Augusta (AGS) to Clemson (CEU)
- Flights from Richmond (RIC) to Clemson (CEU)
- Flights from Syracuse (SYR) to Clemson (CEU)
- Flights from Indianapolis (IND) to Clemson (CEU)
- Flights from Albany (ALB) to Clemson (CEU)
- Flights from Chattanooga (CHA) to Clemson (CEU)
- Flights from Fort Lauderdale (FLL) to Clemson (CEU)
- Flights from Jacksonville (JAX) to Clemson (CEU)
- Flights from Memphis (MEM) to Clemson (CEU)
- Flights from Hilton Head Island (HHH) to Clemson (CEU)
- Flights from Lexington (LEX) to Clemson (CEU)
- Flights from Denver (DEN) to Clemson (CEU)
- Flights from New York (LGA) to Clemson (CEU)
- Flights from West Palm Beach (PBI) to Clemson (CEU)
- Flights from Fort Myers (RSW) to Clemson (CEU)
- Flights from Orlando (ORL) to Clemson (CEU)
- Flights from Houston (HOU) to Clemson (CEU)
- Flights from Los Angeles (LAX) to Clemson (CEU)
- Flights from Minneapolis (MSP) to Clemson (CEU)
- Flights from St. Louis (STL) to Clemson (CEU)
- Flights from San Francisco (SFO) to Clemson (CEU)
- Flights from Buffalo (BUF) to Clemson (CEU)
- Flights from Auburn (AUO) to Clemson (CEU)
- Flights from Seattle (SEA) to Clemson (CEU)
- Flights from Washington (IAD) to Clemson (CEU)
- Flights from Madison (MSN) to Clemson (CEU)
- Flights from Cleveland (CLE) to Clemson (CEU)
- Flights from Florence (FLR) to Clemson (CEU)
- Flights from Harrisburg (MDT) to Clemson (CEU)
- Flights from Phoenix (PHX) to Clemson (CEU)
- Flights from Rochester (ROC) to Clemson (CEU)
- Flights from Burlington (BTV) to Clemson (CEU)
- Flights from Portland (PDX) to Clemson (CEU)
- Flights from Grand Rapids (GRR) to Clemson (CEU)
- Flights from Sarasota (SRQ) to Clemson (CEU)
- Flights from Kansas City (MCI) to Clemson (CEU)
- Flights from Norfolk (ORF) to Clemson (CEU)
- Flights from Cedar Rapids (CID) to Clemson (CEU)
- Flights from Oklahoma City (OKC) to Clemson (CEU)
- Flights from Little Rock (LIT) to Clemson (CEU)
- Flights from Wichita (ICT) to Clemson (CEU)
- Flights from London (LON) to Clemson (CEU)
- Flights from San Jose (SJC) to Clemson (CEU)
- Flights from Fayetteville (FAY) to Clemson (CEU)
- Flights from Toledo (TOL) to Clemson (CEU)
- Flights from Wilkes-Barre (AVP) to Clemson (CEU)
- Flights from Oakland (OAK) to Clemson (CEU)
- Flights from Orlando (SFB) to Clemson (CEU)
- Flights from Binghamton (BGM) to Clemson (CEU)
- Flights from New York (NYC) to Clemson (CEU)
- Flights from Mexico City (MEX) to Clemson (CEU)
- Flights from San Juan (SJU) to Clemson (CEU)
- Flights from Gatlinburg (GKT) to Clemson (CEU)
- Flights from Panama City (PTY) to Clemson (CEU)
- Flights from Colorado Springs (COS) to Clemson (CEU)
- Flights from Fresno (FAT) to Clemson (CEU)
- Flights from Moline (MLI) to Clemson (CEU)
- Flights from Tokyo (TYO) to Clemson (CEU)
- Flights from Sacramento (SMF) to Clemson (CEU)
- Flights from Anderson (AND) to Clemson (CEU)
- Flights from Houston (IAH) to Clemson (CEU)
- Flights from Copenhagen (CPH) to Clemson (CEU)
- Flights from Frankfurt (FRA) to Clemson (CEU)
- Flights from Manchester (MAN) to Clemson (CEU)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.