Find all hotels by La Quinta Inn & Suites in Southern Illinois, IL from $70

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Compare rooms and suites by La Quinta Inn & Suites in Southern Illinois with rates, reviews, and availability. Most hotels are fully refundable.

"Great stay. Rooms very clean & the front desk staff was very helpful. "

$123 total

includes taxes & fees

Jun 30 - Jul 1

"The staff was very nice."

$81 total

includes taxes & fees

Jul 1 - Jul 2

Room, 2 Queen Beds, Non Smoking | Pillowtop beds, desk, blackout drapes, iron/ironing board

"It was alright for the price they ask for deposit "

$104 total

includes taxes & fees

Jul 5 - Jul 6

"Room was clean and comfortable, nice staff…. Old hotel and needs maintenance…. "

$88 total

includes taxes & fees

Jul 3 - Jul 4

La Quinta Inn & Suites Southern Illinois Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of La Quinta Inn & Suites hotels in Southern Illinois, Illinois. Known for well-appointed rooms and friendly, personalized service, each of the top La Quinta Inn & Suites Southern Illinois hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Southern Illinois La Quinta Inn & Suites locations may even offer extra little benefits and discounts for frequent travelers.