A dry grassland with a few trees, a red building, and mountains in the background.

Find 4 Star Hotels in Pickens, SC from $164

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Check availability on Pickens 4 Star Hotels

Tonight
Oct 13 - Oct 14
Tomorrow
Oct 14 - Oct 15
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Pickens 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
colleen
$453 nightly
$499 total
Nov 3 - Nov 4
Total with taxes and fees
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.
A banquet hall with round tables, chandeliers, and ornate windows.

2. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
$176 nightly
$194 total
Nov 1 - Nov 2
Total with taxes and fees
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

3. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
$149 nightly
$164 total
Oct 29 - Oct 30
Total with taxes and fees
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

4. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Amy
$149 nightly
$165 total
Oct 21 - Oct 22
Total with taxes and fees
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.

5. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
$186 nightly
$206 total
Oct 18 - Oct 19
Total with taxes and fees
The Shepherd Hotel Downtown Clemson
A white, two-story house with a front porch, surrounded by trees and shrubs.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A bedroom with two beds, a TV, and a fireplace.
A two-story building with a white exterior, a front door, and a balcony.

6. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
Christine
$174 nightly
$193 total
Oct 14 - Oct 15
Total with taxes and fees
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

7. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveler
$318 nightly
$350 total
Nov 2 - Nov 3
Total with taxes and fees
The Station by Compo Hotels
Terrace/patio
A cozy cabin interior with wooden walls, a dining area, and a unique tree stump feature.
A bedroom with a bed, bedside tables, a desk, and a chair. There is a window with a view of greenery outside.
Private kitchen

8. Tuxedo Falls

Tuxedo Falls
Zirconia
United States
Mary Jane
Tuxedo Falls
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.
A bar with a large window view of mountains and a chandelier.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
$419 nightly
$461 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Domestique
A wooden interior with a hot tub and a pool.
A modern living room with a blue sofa, a wooden side table with a lamp, a ceiling fan, a fireplace, and a large window with blinds.
A bedroom with a wooden bed, a ceiling fan, a nightstand, and a view through a sliding glass door to an outdoor area.
A wooden deck with wicker furniture and a sign that says "EXPLORE".

10. Sapphire Valley Condo w/ Pool & Lake Beach Access!

Sapphire Valley Condo w/ Pool & Lake Beach Access!
Cashiers
Sapphire Valley Condo w/ Pool & Lake Beach Access!
A spacious living room with a large window, a grey sofa, a coffee table, and a dining area with chairs.
A wooden cabin with a deck, surrounded by trees.
A living room with a sectional sofa, a coffee table, and a rug. There are two windows with a view of trees.
A spacious dining area with a wooden table and chairs, a chandelier, and large windows offering views of the outdoors.

11. Sapphire Home w/ Grill & Pool Access

Sapphire Home w/ Grill & Pool Access
Sapphire
United States
William
Sapphire Home w/ Grill & Pool Access
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A cozy living room with a fireplace, leather armchair, and a large window.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveler
Designer Retreat w/ Pool, Golf + Beach Access!
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A two-story yellow house with a front porch, surrounded by greenery and a driveway.
Interior
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.

13. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A large indoor swimming pool with a wooden interior, surrounded by large windows offering views of the outdoors.
A cozy living room with a stone fireplace, a red armchair, a wooden coffee table, and a dining area with a table and chairs.
A lakeside cabin with a covered picnic area and a row of beach chairs along the shore.
A building with a blue roof, wooden exterior, and a porch with a wooden railing.

14. Sunny Sapphire Townhome w/ Resort Amenities!

Sunny Sapphire Townhome w/ Resort Amenities!
Sapphire
Sunny Sapphire Townhome w/ Resort Amenities!
A spacious dining area with a wooden table and chairs, a fireplace, and large windows offering a view of the outdoors.
A two-story house with a covered porch and a front yard.
A spacious dining area with a wooden table and chairs, a large rug, and a view of the kitchen and outdoor area.
A backyard with a fire pit, four Adirondack chairs, a wooden shed, and a small wooden structure with a smiley face.

15. Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
Anderson
Lake Hartwell Frank Howard Home Clemson
Interior
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A multi-story hotel with a parking lot and a view of a lake.
A marina with boats docked, a wooden pier, and a clear sky.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
United States
Kathleen
Lake Keowee Condo w/ Balcony & Resort Amenities!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.
A sandy beach with a calm lake surrounded by trees.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.

17. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A marina with boats docked, surrounded by greenery and trees.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.

18. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.
An aerial view of a residential area with houses, a golf course, and a lake in the background.

19. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A modern living room with a sofa, a coffee table, and a fireplace.

20. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
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Learn more about Pickens

Nestled in the foothills of the Blue Ridge Mountains, this charming town offers a slice of small-town Americana. Hike the trails at Table Rock State Park, then explore the Hagood Mill Historic Site to experience local heritage and traditional bluegrass music.

See all hotels in Pickens
A calm lake reflecting a forested mountain range with autumn foliage.

Top Pickens Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"Wonderful"
colleen 1-night trip
Posted 1 day ago
Grand Bohemian Lodge Greenville, Autograph Collection

Find out more about Pickens

Pickens Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Pickens, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Pickens 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Pickens. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Pickens, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Pickens hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Pickens?
Expedia can help you easily find the ideal 4-star hotel for your vacation in Pickens. Use our handy filter tool to tailor your search by things like price, amenities and hotel star rating and get access to fabulous deals in a couple of clicks.
  • Search for the lowest price from $164
What's the difference between 5-star and 4-star hotels in Pickens?
If you choose to book a stay at a 4-star hotel in Pickens, you'll typically find plenty of amenities to make sure you're relaxed, such as a restaurant, pool and gym. You can enjoy top-quality service and upmarket accommodations. Go for a 5-star hotel and you'll get a few extra perks — think on-site spas, 24-hour front desk and nightly turndown services. You're likely to get extra amenities and premium services at a 5-star getaway, but both are awesome options for luxury guests.
Does Pickens have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to find your next dream getaway in Pickens where everything is taken care of, from your accommodations to your meals, entertainment and activities. We can also help you find standard 4-star stays in and around this popular destination.

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