Default HTG hotel image

Find hotels in Mayo, SC from $55

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 15 - Oct 16
Tomorrow
Oct 16 - Oct 17
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Filter by

Star rating

Guest rating

Our top choices for Mayo hotels

A buffet with various food items, including omelets and cheese.
A vending area with Coca-Cola and Sprite refrigerated drinks, a 'happy place' sign, and snack baskets on shelves.
A hotel room with two beds, a desk, and a view of the outdoors.
A reception desk with a modern design, a blue geometric wall pattern, and a wooden accent wall.

1. Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
Gaffney
United States
Yamil
$76 nightly
$83 total
Nov 1 - Nov 2
Total with taxes and fees
Holiday Inn Express Gaffney by IHG
A hotel lobby with a bar area, seating with patterned upholstery, and a central coffee table.
A fitness center with treadmills, a bench, and exercise equipment.
A snack and beverage vending area with various snacks and drinks.
A hotel room with a large bed, a desk with a television, a chair, and a small table.

2. Hampton Inn Gaffney

Hampton Inn Gaffney
Gaffney
United States
sara
$99 nightly
$108 total
Nov 1 - Nov 2
Total with taxes and fees
Hampton Inn Gaffney
A modern lobby with a blue sofa, a reception desk, and a large cityscape painting.
A gym with treadmills, dumbbells, and a wall with motivational words.
A hotel room with two beds, a nightstand, and a wall-mounted TV.
A Best Western Plus hotel with a parking lot and multiple cars parked in front.

3. Best Western Plus Spartanburg

Best Western Plus Spartanburg
Spartanburg
United States
Jamie
$93 nightly
$103 total
Oct 25 - Oct 26
Total with taxes and fees
Best Western Plus Spartanburg
A hotel dining area with multiple tables and chairs, a television mounted on a wall, and a kitchen area visible in the background.
A hotel reception area with a counter, a refrigerator, and a sign indicating a Sleep Inn.
A living room with a sofa, two armchairs, a coffee table, and a patterned rug.
A hotel with a swimming pool, lounge chairs, and a covered seating area.

4. Sleep Inn Gaffney at I-85

Sleep Inn Gaffney at I-85
Gaffney
United States
Ken
$67 nightly
$75 total
Nov 5 - Nov 6
Total with taxes and fees
Sleep Inn Gaffney at I-85
A modern bedroom with a large bed, a built-in TV, and a small desk.
A reception area with a modern design, including a large number '6' sign, a coffee machine, and a TV mounted on the wall.
A modern bathroom with a shower, toilet, and sink.
A motel with multiple floors, balconies, and a parking lot.

5. Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85
Spartanburg
United States
Connie
$58 nightly
$64 total
Nov 11 - Nov 12
Total with taxes and fees
Motel 6 Spartanburg, Sc – Northwest / Business 85
A hotel room with two beds, a desk, a refrigerator, a television, and a bathroom visible through an arched doorway.
A modern bathroom with a large bathtub, a chair, and a floor lamp.
A hotel with a well-lit entrance, multiple parking spaces, and a clear view of the sky.
A hotel kitchen with a buffet setup, including a coffee station, a refrigerator, and a microwave.

6. Comfort Inn & Suites Spartanburg North

Comfort Inn & Suites Spartanburg North
Spartanburg
United States
Lisa
$84 nightly
$93 total
Nov 8 - Nov 9
Total with taxes and fees
Comfort Inn & Suites Spartanburg North
Room
A wooden gazebo with a metal roof, a bench, and a ramp leading up to it.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee station.
A modern lobby with a large white reception desk, brown leather sofas, a round coffee table, and a ceiling light fixture.

7. Days Inn by Wyndham Spartanburg

Days Inn by Wyndham Spartanburg
Boiling Springs
United States
antonio
$79 nightly
$88 total
Oct 19 - Oct 20
Total with taxes and fees
Days Inn by Wyndham Spartanburg
A modern lobby with a reception desk, seating area, and a television screen.
A hotel with a covered entrance, brick exterior, and a sign indicating it is a Best Western hotel.
A hotel room with two beds, a desk with a lamp, a chair, a patterned rug, and a large window.
A swimming pool with lounge chairs and tables, surrounded by brick buildings and a covered seating area.

8. Best Western Spartanburg I-26

Best Western Spartanburg I-26
Spartanburg
United States
Santhosh
$93 nightly
$103 total
Nov 1 - Nov 2
Total with taxes and fees
Best Western Spartanburg I-26
A hotel room with a bed, a TV, a desk, and a microwave.
Two vending machines, one with a Pepsi logo and the other with a FreshChoices label.
A multi-story building with a covered parking area.
Two white front-loading washing machines in a corner with a tiled floor.

9. Red Roof Inn Gaffney

Red Roof Inn Gaffney
Gaffney
United States
Belinda
$62 nightly
$70 total
Oct 25 - Oct 26
Total with taxes and fees
Red Roof Inn Gaffney
A lobby with a leather sofa, two lamps, a painting, and potted plants.
A dining area with a high ceiling, wooden chairs, a table, and a kitchen area with a TV and food display.
A hotel lobby with a reception desk, a waiting area with a chair, and a large window providing a view of the outside.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom visible through an open door.

10. Quality Inn Gaffney I-85

Quality Inn Gaffney I-85
Gaffney
United States
Betina
$50 nightly
$55 total
Nov 8 - Nov 9
Total with taxes and fees
Quality Inn Gaffney I-85
A hotel room with a bed, a blue sofa, a wooden coffee table, a desk with a chair, and a framed abstract painting on the wall.
A food service counter with a sign that reads "EXPRESS START".
A hotel reception area with a wooden reception desk, a receptionist, and a revolving door.
A large indoor swimming pool with a diving board, multiple doors, and seating areas.

11. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Spartanburg
United States
Nephie
$107 nightly
$119 total
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
A conference room with a long table, blue and orange chairs, and a reception desk in the background.
A coffee station with labeled dispensers for hot water, decaf roast, light roast, and dark roast coffee.
A Hampton Inn hotel with a clear entrance, well-maintained lawn, and a flagpole.
A gym with treadmills, elliptical machines, and weight machines.

12. Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85
Spartanburg
United States
Britt
$127 nightly
$141 total
Nov 8 - Nov 9
Total with taxes and fees
Hampton Inn Spartanburg-North I-85
A multi-level hotel lobby with seating areas, a fireplace, and a staircase.
A modern hotel building with a large glass facade, a covered entrance, and a sign reading "Four Points by Sheraton".
An indoor swimming pool with clear blue water, surrounded by lounge chairs and wooden panel walls.
A modern coffee bar with a glass display case, seating area with round tables and chairs, and a wooden ceiling.

13. Four Points by Sheraton Spartanburg

Four Points by Sheraton Spartanburg
Spartanburg
United States
Elaine
$116 nightly
$129 total
Oct 25 - Oct 26
Total with taxes and fees
Four Points by Sheraton Spartanburg
An outdoor seating area with sofas, a fire pit, and string lights.
A self-service kiosk with a variety of snacks and beverages, a microwave, and a refrigerated display.
A modern lounge area with seating arrangements, a large window offering a view of the outdoors, and contemporary lighting fixtures.
A modern hotel with a multi-story structure, large windows, and a prominent vertical light strip.

14. Tru by Hilton Spartanburg

Tru by Hilton Spartanburg
Spartanburg
United States
Anthony
$106 nightly
$117 total
Nov 1 - Nov 2
Total with taxes and fees
Tru by Hilton Spartanburg
A modern reception area with a counter, seating, and a bookshelf with various items.
Bar (on property)
A clinical setting with medical equipment, a large mirror, and a window providing natural light.
A multi-story hotel with a stone facade and multiple windows, featuring a parking lot and landscaped areas.

15. Holiday Inn Spartanburg Northwest by IHG

Holiday Inn Spartanburg Northwest by IHG
Spartanburg
United States
Carla
$98 nightly
$109 total
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn Spartanburg Northwest by IHG
A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.
A hotel room with a bed, a gray sofa, two ottomans, a window with a view, and abstract artwork on the wall.
A modern lobby with blue sofas, a reception desk, and a glass coffee table.
A hotel room with a desk, office chair, sofa, and a large wall art piece.

16. Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall
Spartanburg
United States
Willie
$91 nightly
$101 total
Nov 8 - Nov 9
Total with taxes and fees
Comfort Suites At WestGate Mall
A hotel room with two beds, a desk, a chair, and a large window with autumn foliage artwork.
A hotel room with a wooden desk, a black chair, a small refrigerator, a microwave, and a TV on the wall.
A self-service coffee station with a Folgers Select Brew coffee maker and a vintage-themed beverage dispenser.
A spacious indoor area with a large glass door leading outside, a ceiling fan, and a counter with various items.

17. Days Inn by Wyndham Spartanburg Waccamaw

Days Inn by Wyndham Spartanburg Waccamaw
Spartanburg
United States
Rebecca
$62 nightly
$69 total
Oct 22 - Oct 23
Total with taxes and fees
Days Inn by Wyndham Spartanburg Waccamaw
A modern living room with a fireplace, two sofas, and a coffee table.
A modern gym with various exercise equipment, motivational wall graphics, and a large window offering a view of the outdoors.
A hotel room with two beds, a desk, a TV, and a window with curtains.
A reception area with two wooden reception desks, a blue accent wall, and a mounted television.

18. Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
Spartanburg
United States
Herbert
$95 nightly
$105 total
Nov 1 - Nov 2
Total with taxes and fees
Best Western Spartanburg Northwest
A hotel reception area with a red sign indicating free Wi-Fi in all rooms, a control panel, a laptop, and a payment terminal.
A hotel with a red sign reading 'Red Roof Inn & Suites' and a two-story structure with multiple windows and balconies.
A hotel room with two beds, a bathroom, and a hallway.
A vending machine with snacks and a drink dispenser.

19. Red Roof Inn Spartanburg - I-85

Red Roof Inn Spartanburg - I-85
Spartanburg
United States
Walker
$65 nightly
$72 total
Oct 18 - Oct 19
Total with taxes and fees
Red Roof Inn Spartanburg - I-85
A hotel lobby with a reception desk, green sofa, patterned armchairs, and a potted plant.
A hotel room with a bed, desk, chair, television, and lamps.
A motel with multiple rooms, a blue awning, and a red car parked in front.
A kitchen with wooden cabinets, a black refrigerator, and a dining area with chairs and a table.

20. Baymont by Wyndham Gaffney

Baymont by Wyndham Gaffney
Gaffney
United States
Kelly
$61 nightly
$69 total
Oct 18 - Oct 19
Total with taxes and fees
Baymont by Wyndham Gaffney
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Mayo Hotel Reviews

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

8/10 Good
"Out side had trash everywhere"
Bruce 2-night trip
Posted 3 days ago
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Days Inn by Wyndham Spartanburg Waccamaw

Days Inn by Wyndham Spartanburg Waccamaw

10/10 Excellent
"Room was very clean and I will definitely be booking again for when I want to get away and relax"
christopher 1-night trip
Posted 4 days ago
Days Inn by Wyndham Spartanburg Waccamaw
Hilton Garden Inn Spartanburg

Hilton Garden Inn Spartanburg

10/10 Excellent
"Just all around exceptional ! Will stay again when ever I pass through!"
Mary 1-night trip
Posted 4 days ago
Hilton Garden Inn Spartanburg
Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

10/10 Excellent
"The staff were all very friendly and helpful. The room was clean and very nice."
Laura Michelle 1-night trip
Posted 5 days ago
Extended Stay America Premier Suites - Greenville - Spartanburg - I-85
Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

10/10 Excellent
"The front desk staff was exceptionally pleasant. The hotel was clean and smelled amazing. Very comfortable and relaxing. Breakfast was good! Had a great stay and we will be back!"
aprelle 1-night trip
Posted 11 days ago
Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

More cheap stays in Mayo

Rodeway Inn Expo Center

Rodeway Inn Expo Center

2070 New Cut Rd Spartanburg SC
$57 nightly
$63 total
Oct 22 - Oct 23
Total with taxes and fees
5.8/10 (500 reviews)
Rodeway Inn Expo Center
Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85

820 Hospitality Drive Spartanburg SC
$58 nightly
$64 total
Nov 11 - Nov 12
Total with taxes and fees
Motel 6 Spartanburg, Sc – Northwest / Business 85
WoodSpring Suites Spartanburg - Duncan

WoodSpring Suites Spartanburg - Duncan

255 Frontage Rd. Duncan SC
$64 nightly
$72 total
Oct 16 - Oct 17
Total with taxes and fees
6/10 (295 reviews)
WoodSpring Suites Spartanburg - Duncan
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

458 West Blackstock Road Spartanburg SC
$91 nightly
$101 total
Nov 8 - Nov 9
Total with taxes and fees
Comfort Suites At WestGate Mall
Best Western Spartanburg I-26

Best Western Spartanburg I-26

488 South Blackstock Road Spartanburg SC
$93 nightly
$103 total
Nov 1 - Nov 2
Total with taxes and fees
Best Western Spartanburg I-26
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

161 Sha Ln Spartanburg SC
$107 nightly
$119 total
Nov 15 - Nov 16
Total with taxes and fees
8.6/10 Excellent! (1,000 reviews)
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Hotels in Mayo with star-rating

Frequently asked questions

What is the best area to stay in Mayo?
The best area to stay in Mayo is the town center, particularly around Main Street, as it offers the most convenience for visitors.This central area of Mayo is where you'll find the majority of local businesses, including eateries and shops. It's a compact and walkable district, making it easy to access amenities. The town hall and the local library are also situated here, providing a central point for navigation.For solo travelers or couples, staying in the town center provides easy access to local dining and any community events that might be happening.
When is the best time to go to Mayo?
The best time to visit Mayo, South Carolina, is during the spring (April to June) and fall (September to November) months.During these periods, the weather is pleasantly mild, with comfortable temperatures and lower humidity, making it ideal for outdoor activities and exploring the local area without the intense heat of summer. You'll find many local events and festivals taking place, offering a great way to experience the community's culture.For travelers looking for a relaxed experience, these seasons offer peaceful surroundings.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Mayo.
How much is the nightly rate at a Mayo hotel?
Prices for hotels in Mayo often vary, but you can find a great deal from $55 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia