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Find Hotels in Otay Mesa, San Diego

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Otay Mesa hotels and places to stay

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $127 per night from Aug 16 to Aug 16
3.8/5Good! (3,252 reviews)
"The price for the hotel was a extremely high but it is summer time."

Reviewed on Jul 27, 2021

Best Western Seven Seas
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $144 per night from Aug 25 to Aug 25
4.4/5Excellent! (379 reviews)
"Great place"

Reviewed on Jul 28, 2021

Legacy Resort Hotel & Spa
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $129 per night from Aug 9 to Aug 9
3.8/5Good! (899 reviews)
"Excellent service, very nice people"

Reviewed on Jul 27, 2021

Handlery Hotel
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Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $119 per night from Aug 22 to Aug 22
3.9/5Very Good! (1,957 reviews)
"I really loved all the palms surrounding the hotel, it truly gave it that “getaway feeling”. Our room in the sunset building was super spacious and peaceful. The whole place just had a homey feeling to it, not stuffy like some other places we’ve stayed out. It’s also only about 10-20 mins away from ..."

Reviewed on Jul 27, 2021

Days Inn by Wyndham San Diego Hotel Circle
Town and Country San Diego

Town and Country San Diego

4 out of 5
500 Hotel Circle North, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $114 per night from Aug 15 to Aug 15
3.5/5Good! (125 reviews)
"Everything was very beautiful, except the parking. They charged for parking and it was too expensive $25."

Reviewed on Jul 27, 2021

Town and Country San Diego
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

4 out of 5
8757 Rio San Diego Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $199 per night from Aug 29 to Aug 29
4.2/5Very Good! (921 reviews)
"Excellent location close to everything!"

Reviewed on Jul 25, 2021

San Diego Marriott Mission Valley
Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection

4 out of 5
421 W B St, San Diego, CA
The price is $163 per night from Aug 15 to Aug 15
4.5/5Wonderful! (1,438 reviews)
"The location of the property is very convenient. The rooms were decent size. The property is very much a young professionals vibe and we enjoyed that."

Reviewed on Jul 26, 2021

Hotel Republic San Diego, Autograph Collection
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
The price is $197 per night from Aug 15 to Aug 15
4.4/5Wonderful! (3,250 reviews)
"Great views, clean rooms, great staff and everything is within walking distance"

Reviewed on Jul 27, 2021

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $169 per night from Aug 16 to Aug 16
4/5Very Good! (4,036 reviews)
"All of the exquisite restaurants on-site. It was the best!!"

Reviewed on Jul 28, 2021

Wyndham San Diego Bayside
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $249 per night from Aug 29 to Aug 29
4.1/5Very Good! (2,208 reviews)
"It was a tropical land and living in the desert it was such a amazing site"

Reviewed on Jul 25, 2021

Bahia Resort Hotel
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
The price is $239 per night from Aug 1 to Aug 1
4.2/5Very Good! (1,791 reviews)
"It was great, staff was very friendly!"

Reviewed on Jul 24, 2021

Hard Rock Hotel San Diego
The Horton Grand Hotel

The Horton Grand Hotel

3.5 out of 5
311 Island Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $161 per night from Aug 15 to Aug 15
4.3/5Excellent! (1,553 reviews)
"We had access to everything in town either on foot or by trolley."

Reviewed on Jul 27, 2021

The Horton Grand Hotel
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Fully refundableReserve now, pay when you stay
The price is $254 per night from Aug 29 to Aug 29
4.3/5Excellent! (1,323 reviews)
"Beautiful Resort! Awesome Views, Excellent Service, Great Amenities! All of these made up for a great staycation! Will definitely go to this beautiful resort again!"

Reviewed on Jul 27, 2021

Loews Coronado Bay Resort
InterContinental San Diego, an IHG Hotel

InterContinental San Diego, an IHG Hotel

4 out of 5
901 Bayfront Court, San Diego, CA
Fully refundable
The price is $224 per night from Aug 16 to Aug 16
4.4/5Excellent! (1,521 reviews)
"The location is fantastic just at walking distance to little Italy restaurants and shops, seaport village , and just across the street to take the ferry to Coronado island. Staff was super friendly . Parking at he properties was easy and convenient. We had a great time enjoying the hotel and San ..."

Reviewed on Jul 27, 2021

InterContinental San Diego, an IHG Hotel
Omni San Diego Hotel

Omni San Diego Hotel

4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $197 per night from Aug 2 to Aug 2
4.5/5Wonderful! (1,418 reviews)
"We were greeted via text ahead of time, which was awesome and we felt that extra step was totally new, and they provided quick responses including dinning recommendations. We were greeted onsite with doormen that were super friendly and responsive, offering to unload our bags and carry them in. When ..."

Reviewed on Jul 27, 2021

Omni San Diego Hotel
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

2 out of 5
230 Broadway, Chula Vista, CA
Fully refundableReserve now, pay when you stay
The price is $100 per night from Aug 8 to Aug 8
3.3/5 (904 reviews)
"I like it 👌"

Reviewed on Jul 25, 2021

Hotel Palmeras Chula Vista
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $296 per night from Aug 29 to Aug 29
4.1/5Very Good! (389 reviews)
"This was a great place to stay! It is a beautiful resort and very well located. There are lots of activities for kids throughout the day as well as lots of things to do around the property -- cornhole, firepits, chess, checkers and beautiful things to look at. I highly recommend the firepit ..."

Reviewed on Jul 26, 2021

San Diego Mission Bay Resort
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundable
The price is $296 per night from Aug 22 to Aug 22
4/5Very Good! (909 reviews)
"I wish the pool bar and market were open longer hours, but everything was fantastic."

Reviewed on Jul 28, 2021

Hyatt Regency Mission Bay Spa and Marina
Humphreys Half Moon Inn

Humphreys Half Moon Inn

3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $219 per night from Aug 23 to Aug 23
4.3/5Excellent! (1,504 reviews)
"Humphreys is an awesome hotel with a relaxing vibe and safe environment! Staff is great. Rooms are clean and comfortable. Their restaurant has the best view of the water while enjoying a tasty meal!"

Reviewed on Jul 26, 2021

Humphreys Half Moon Inn
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is $203 per night from Aug 29 to Aug 29
4.2/5Very Good! (2,097 reviews)
"Great place to stay"

Reviewed on Jul 24, 2021

The Dana on Mission Bay
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Otay Mesa, San Diego Hotel Information

Expedia.com offers a selection of 3470 hotels in Otay Mesa, San Diego. You are sure to find cheap deals and discount rates among them with our Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs.

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Frequently asked questions

Recent reviews of Otay Mesa hotels

    Quality Suites San Diego Otay Mesa
    Expedia Verified Review
    5 / 5 Excellent
    Everything was quick and easy hotel staff was very friendly room was equipped with everything
    A verified traveler stayed at Quality Suites San Diego Otay Mesa
    Posted 5 months ago
    Quality Suites San Diego Otay Mesa
    Legacy Resort Hotel & Spa
    Expedia Verified Review
    5 / 5 Excellent
    Great place
    A verified traveler stayed at Legacy Resort Hotel & Spa
    Posted 16 hours ago
    Legacy Resort Hotel & Spa
    Manchester Grand Hyatt San Diego
    Expedia Verified Review
    5 / 5 Excellent
    Great views, clean rooms, great staff and everything is within walking distance
    A verified traveler stayed at Manchester Grand Hyatt San Diego
    Posted 1 day ago
    Manchester Grand Hyatt San Diego
    Marriott Marquis San Diego Marina
    Expedia Verified Review
    5 / 5 Excellent
    The parking wasn’t very good
    A verified traveler stayed at Marriott Marquis San Diego Marina
    Posted 2 days ago
    Marriott Marquis San Diego Marina
    Wyndham San Diego Bayside
    Expedia Verified Review
    5 / 5 Excellent
    All of the exquisite restaurants on-site. It was the best!!
    A verified traveler stayed at Wyndham San Diego Bayside
    Posted 7 hours ago
    Wyndham San Diego Bayside

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