$283 Cheap Flights from Buffalo (BUF) to Key West (EYW)

Buffalo (BUF) to Key West (EYW) at a glance

Explore a range of options for Buffalo to Key West flights on this domestic short-haul route. You can choose between full-service and low-cost carriers, allowing you to select the itinerary that aligns with your budget and travel schedule. As you prepare to visit the iconic sights and neighborhoods of Key West, be sure to check the essential information for flights from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW).

• Fastest flight duration: around 4h 30m in-flight, plus roughly 1h 15m layover with one stop
• Route distance: roughly 1,300 miles (2,090 km)
• Flights per week: around 10 departures on average
• Typical fares (one-way): economy tickets often range from $115–$470, depending on seasonality and how far ahead you book

Flights from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)

According to recent traveler bookings, the top airlines for flights from Buffalo to Key West are favored for their one-stop services, typically with layovers at Charlotte-Douglas International Airport (CLT, approximately 1 hour 15 minutes), Hartsfield-Jackson Atlanta International Airport (ATL, around 1 hour 15 minutes), and LaGuardia Airport (LGA, about 1 hour 30 minutes). These options provide you with the flexibility to compare prices, total travel times, and cabin classes to secure the best itinerary for your trip.

• American Airlines: This full-service airline provides one-stop flights, with one-way fares generally falling between $125 and $550. It operates around 61% of the departures on this route, featuring an in-flight duration of 4 hours and 30 minutes, and a total travel time of approximately 5 hours and 45 minutes, including layover time.
• Delta: Delta is a full-service airline that also offers one-stop flights, with one-way fares typically priced from $115 to $445. It handles around 28% of the departures on this route, boasting an in-flight time of 4 hours and 30 minutes and a total journey time of about 5 hours and 45 minutes, factoring in the layover.
• United: As a full-service airline with one-stop options, United's one-way fares usually range from $125 to $425. It accounts for roughly 7% of the departures on this route, with an in-air time of 4 hours and 30 minutes and an overall travel duration of about 5 hours and 45 minutes, including layover time.
• JetBlue Airways: JetBlue, a low-cost airline, offers one-stop service with one-way fares typically between $120 and $480. It makes up around 4% of the departures on this route, presenting an in-flight time of 4 hours and 30 minutes and a total travel time of roughly 5 hours and 45 minutes, including layover time.

Travelers flying from Buffalo to Key West can opt for an upgrade, as American Airlines provides first-class service on this route.

Best time to fly from Buffalo (BUF) to Key West (EYW)

The most popular months for travelers flying from Buffalo to Key West are January, February, and March, when peak temperatures in Key West reach up to 73.4°F in March. If you prefer quieter travel, consider September, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 83.7°F. For better deals, August usually offers the lowest average one-way fare around $192. Flight availability peaks in February and March, with approximately 12 flights per week, making it easier to find convenient departure times. May and July have the fewest flights, with approximately 7 flights per week.

• Cheapest time to fly: August usually offers good deals with average one-way fare around $192, roughly 22% cheaper than the yearly average.
• More budget-friendly months to fly: October and September typically offer average one-way fares of around $202.
• Most flight options: February and March have the highest number of flights from Buffalo to Key West, with approximately 12 flights per week, giving you more flexibility in scheduling your trip.

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Buffalo (BUF) to Key West (EYW)

• Rochester to Key West (ROC-EYW): Located approximately 56 miles from Buffalo Niagara International Airport (BUF), Greater Rochester International Airport (ROC) offers travelers a variety of one-way economy fares for this route, typically falling between $125 and $525, influenced by the season and the timing of the booking. This route features both one-stop and multi-stop flight options, with common layover points including Charlotte-Douglas International Airport (CLT) and Hartsfield-Jackson Atlanta International Airport (ATL). Major airlines operating on this route include American Airlines and Delta, with first-class service also available.

How to find the best prices for flights from Buffalo (BUF) to Key West (EYW)

Getting some of the best deals on flights from Buffalo to Key West is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are usually found when booking at least two months in advance, which is when most travelers make their reservations. Afternoon departures between 12 PM and 6 PM often offer lower prices, although morning flights from 5 AM to 12 PM are the most popular. Additionally, flying on Sunday tends to be cheaper, while Saturday remains the busiest travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Key West hotel and flight deals.
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Key West International Airport from Buffalo Niagara International Airport

Key West welcomes travelers from Buffalo with a range of transport options based on price, convenience, and proximity. Here's how to reach Key West efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Key West, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
• Car rental: Renting a car from Key West International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Key West International Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Key West International Airport, Key West Seaport, a seaport, is located about 3.7 miles away by car.

Buffalo to Key West Flights

The cheapest times to fly from Buffalo to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Key West are during the month of March. You can find some of the cheapest flights from Buffalo to Key West with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Buffalo to Key West

Sunday is one of the best days to book for cheap flights from Buffalo to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Buffalo to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Key West in 2026. You can also book with separate airlines for your outbound and return journeys, from $283 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.