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Find hotels in Cape Girardeau, MO from $50

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May 11 - May 12
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May 12 - May 13
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May 17 - May 19

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Compare 155 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Auburn Place Hotel And Suites
Indoor pool
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1004)
"Great location. 5/10 mins away from everything "
The price is $66
per night
Jun 5 - Jun 6
Auburn Place Hotel And Suites
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
9.6 out of 10, Exceptional, (1000)
"Great place to stay!"
The price is $112
per night
May 22 - May 23
Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau West
Exterior
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1002)
"when got inside room there was a VERY STRONG smell of smoking. Went down to desk and reported it. Desk clerk was very responsible and got us a different room immediately."
The price is $67
per night
Jun 2 - Jun 3
Pear Tree Inn Cape Girardeau West
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Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
9.0 out of 10, Wonderful, (1003)
"Staff is very helpful and welcoming"
The price is $67
per night
May 16 - May 17
Pear Tree Inn Cape Girardeau Near the Medical Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 star property
9.6 out of 10, Exceptional, (1002)
"Staff very friendly and helpful !"
The price is $117
per night
May 19 - May 20
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 star property
9.0 out of 10, Wonderful, (371)
"A nice, clean , quiet property. Very good buy"
The price is $90
per night
May 26 - May 27
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Cape Girardeau
Exterior
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (774)
"Staff was great. "
The price is $108
per night
May 16 - May 17
Drury Inn & Suites Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
9.6 out of 10, Exceptional, (338)
"A clean facility"
The price is $130
per night
May 26 - May 27
Courtyard by Marriott Cape Girardeau Downtown
Candlewood Suites Cape Girardeau, an IHG Hotel
Exterior
Candlewood Suites Cape Girardeau, an IHG Hotel
2.5 star property
8.2 out of 10, Very Good, (621)
"Very friendly staff very clean "
The price is $88
per night
May 14 - May 15
Candlewood Suites Cape Girardeau, an IHG Hotel
Hampton Inn Cape Girardeau I 55 East
Pool
Hampton Inn Cape Girardeau I 55 East
2.5 star property
9.6 out of 10, Exceptional, (618)
"No deposit, which i like, was clean, pool aas nice, food was good at breakfast"
The price is $114
per night
May 19 - May 20
Hampton Inn Cape Girardeau I 55 East
Quality Inn
Exterior
Quality Inn
2.5 star property
7.0 out of 10, Good, (457)
"Nice room, nice breakfast area. "
The price is $67
per night
May 28 - May 29
Quality Inn
Comfort Suites Jackson-Cape Girardeau
Exterior
Comfort Suites Jackson-Cape Girardeau
2.5 star property
8.2 out of 10, Very Good, (634)
"It was clean"
The price is $97
per night
May 12 - May 13
Comfort Suites Jackson-Cape Girardeau
Cozy cabins on beautiful Horseshoe Lake
The Labrador Room
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, (18)
"We were looking for a place to view the 2024 solar eclipse and we found this cabin, which was in the path of totality! We were so excited to be able to view the eclipse from the property, which meant that we didn't have to deal with traffic getting home or to other lodging. Sherry was a great host. The cabin was quiet and clean. and just perfect for a two-night stay. "
The price is $115
per night
May 12 - May 13
Cozy cabins on beautiful Horseshoe Lake
Town House Inn
Room
Town House Inn
2.5 star property
8.0 out of 10, Very Good, (289)
"Housekeeping guy was great, checked in on us to make sure we didn't need anything. We stayed 2 nights. Everything was clean and great except the beds were pretty hard. Other than that we loved it."
The price is $50
per night
May 19 - May 20
Town House Inn
Town House Inn Cape Giradreau
Exterior
Town House Inn Cape Giradreau
2.5 star property
6.0 out of 10, (138)
"Nothing like the one in jackson. I stayed at the townhouse inn in jackson mo then the one in cape girardeau. The one in jackson 10 stars the one in cape 2 stars so its woryh the 5 min drive "
The price is $75
per night
May 12 - May 13
Town House Inn Cape Giradreau
The Rested Duck Mallard Room
Room
The Rested Duck Mallard Room
8.8 out of 10, Excellent, (14)
"Lovely, unexpected gem! I would love to come back again!"
The price is $115
per night
May 12 - May 13
The Rested Duck Mallard Room
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Living area
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
9.8 out of 10, Exceptional, (17)
"Town was cute and ecclectic, stay at VRBO gave the same vibes. Very clean and fun. We only stayed for 1 night but would love to come back- stopped by Annie Laurie’s, Indie House, Kenny’s Flippin Burgers, Ebb and Flow brewery and Broadway Bistro/vintage store. We recommend all of them!"
The price is $91
per night
May 12 - May 13
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Little Blue Cottage on Spanish
Private kitchen
Little Blue Cottage on Spanish
8.8 out of 10, Excellent, (32)
"We stayed here to visit our two children going to SEMO. Everything about the place was perfect for a couple. The place was cute and the location was perfect"
The price is $90
per night
May 15 - May 16
Little Blue Cottage on Spanish
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
Aerial view
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
10.0 out of 10, Exceptional, (1)
"As described. Happy with the experience for the eclipse."
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
Beautiful Cabin Retreat
Exterior
Beautiful Cabin Retreat
8.2 out of 10, Very Good, (39)
"Host had the cabin very clean. New leather couch & recliner. Mattress was extremely comfortable. Washer & Dryer were excellent. Another Rental house near, long-term renters were very quiet. Internet not very good in the Illinois woods. Closed cabin has a musty smell from humidity in the woods. Host had an automatic air freshener going to help with air quality."
The price is $120
per night
May 12 - May 13
Beautiful Cabin Retreat
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Where can I learn more about changing or cancelling my trip to Cape Girardeau?

For more details about picking new dates or cancelling your trip to Cape Girardeau, head over to our customer service page.

What's the weather like in Cape Girardeau?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.