You'll go home with a head full of facts after a visit to Leonardo da Vinci Museum. Each piece here has a tale to tell, so be sure to take your time studying the displays.
You'll be spoiled for sightseeing choice when visiting Duomo. Leonardo da Vinci Museum is a good place to start here, but there are loads of other fine spots to visit. Ponte Vecchio, Cathedral of Santa Maria del Fiore, and Uffizi Gallery are near the museum and will round out your day nicely.