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Find all hotels by Motel 6 in Southeast Missouri, MO

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Compare rooms and suites by Motel 6 in Southeast Missouri with rates, reviews, and availability. Most hotels are fully refundable.

"This hotel was conveniently located to the highway. Check-in was easy. Nothing fancy, but it was a bed to sleep in on our late check-in and early check-out."

$82 total

includes taxes & fees

Jun 16 - Jun 17

"While overall the stay was ok.. there were a few issues.. one the tub would not fill up, two there were roaches crawling on the walls and three there were spiders crawling in room"

Motel 6 Southeast Missouri Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Motel 6 hotels in Southeast Missouri, Missouri. Known for well-appointed rooms and friendly, personalized service, each of the top Motel 6 Southeast Missouri hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Southeast Missouri Motel 6 locations may even offer extra little benefits and discounts for frequent travelers.