Photo by Jessica Richter

Find all hotels by Independent in Southeast Missouri, MO from $52

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Compare rooms and suites by Independent in Southeast Missouri with rates, reviews, and availability. Most hotels are fully refundable.

Auburn Place Hotel And Suites
BBQ/picnic area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, 1,004 reviews
"Very impressed with this hotel, I will be staying again."
The price is $66
$75 total
includes taxes & fees
Jul 15 - Jul 16
Auburn Place Hotel And Suites
New Orleans Inn Portageville
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville
2.5 star property
8.0 out of 10, Very Good, 441 reviews
"The customer service was out of this world made me feel right at homeill definitely be staying there again"
The price is $52
$56 total
includes taxes & fees
Jun 23 - Jun 24
New Orleans Inn Portageville
Travel Inn & Suites
Hallway
Travel Inn & Suites
2.5 star property
8.4 out of 10, Very Good, 529 reviews
"Very clean and good especially for the budget pice"
The price is $56
$64 total
includes taxes & fees
Jul 11 - Jul 12
Travel Inn & Suites
Town House Inn
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn
2.5 star property
8.0 out of 10, Very Good, 302 reviews
"Staff great"
The price is $56
$60 total
includes taxes & fees
Jul 15 - Jul 16
Town House Inn
The Farmstead Hotel
Reception
The Farmstead Hotel
2.5 star property
8.8 out of 10, Excellent, 201 reviews
"Small and quiet "
The price is $102
$117 total
includes taxes & fees
Jun 18 - Jun 19
The Farmstead Hotel
Honeysuckle Inn - Mountain View
Front of property
Honeysuckle Inn - Mountain View
3.0 star property
8.6 out of 10, Excellent, 194 reviews
"An older hotel but well kept up, very clean. Quiet. We had an issue with a disabled family member, staff was very helpful & kind. "
The price is $102
$111 total
includes taxes & fees
Jun 27 - Jun 28
Honeysuckle Inn - Mountain View
Dexter Inn
Exterior
Dexter Inn
2.5 star property
7.0 out of 10, Good, 242 reviews
"I liked everything "
The price is $58
$66 total
includes taxes & fees
Jun 24 - Jun 25
Dexter Inn
Current River Inn
BBQ/picnic area
Current River Inn
3.0 star property
8.0 out of 10, Very Good, 106 reviews
"Birthday weekend Owners are very friendly and rooms are clean and nice. "
The price is $80
$87 total
includes taxes & fees
Jun 17 - Jun 18
Current River Inn
Madison Inn Lodge
Interior entrance
Madison Inn Lodge
2.5 star property
7.4 out of 10, Good, 227 reviews
"Nice place will be a repeat customer."
The price is $87
$95 total
includes taxes & fees
Jul 8 - Jul 9
Madison Inn Lodge
Country Yard Inn and Suite
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite
2.0 star property
7.4 out of 10, Good, 35 reviews
"Considering the price of the room, it was adequate. Thankfully it was a cooler weekend (the previous week had been uncharacteristically warm) or we would have had to move rooms due to an inadequate air conditioning unit. That being said, it was a clean room and the bed was comfortable. The motel is convenient to the interstate and the main road into Sikeston. Our room was at the far end of the motel, so away from any interstate noise."
The price is $59
$70 total
includes taxes & fees
Jun 30 - Jul 1
Country Yard Inn and Suite
Don't see what you're looking for?
See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent Southeast Missouri Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Southeast Missouri, Missouri. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Southeast Missouri hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Southeast Missouri Independent locations may even offer extra little benefits and discounts for frequent travelers.

Recent reviews of Southeast Missouri hotels
Expedia verified reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

5/5 Excellent
"Cool place "
A verified traveler stayed at Drury Inn & Suites Sikeston, MO
Posted 3 days ago
Drury Inn & Suites Sikeston, MO